HLA typing using genome wide data reveals susceptibility types for infections in a psychiatric disease enriched sample

Parks, Samuel; Avramopoulos, Dimitrios; Mullé, Jennifer G.; McGrath, John A.; Wang, Ruihua; Goes, Fernando S.; Conneely, Karen N.; Ruczinski, Ingo; Yolken, Robert H.; Pulver, Ann E.; Pearce, Brad D.

doi:10.1016/j.bbi.2018.03.001

Cited by 12 publications

(9 citation statements)

References 60 publications

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“…For example, HLA genes of the major histocompatibility complex (MHC) have the strongest genetic predisposition for SCZ in genome‐wide association studies ( 47 ). Similarly, MHC genes may affect susceptibility to Toxoplasma infections ( 48 , 49 ). Certain HLA alleles (e.g., HLA C*04:01 allele) have been shown to decrease susceptibility to T. gondii infection in patients with SCZ but not in controls ( 49 ).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, MHC genes may affect susceptibility to Toxoplasma infections ( 48 , 49 ). Certain HLA alleles (e.g., HLA C*04:01 allele) have been shown to decrease susceptibility to T. gondii infection in patients with SCZ but not in controls ( 49 ). Interactions between genetic and environmental risk factors merit further investigation ( 46 ).…”

Section: Discussionmentioning

confidence: 99%

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Toxoplasmosis and Schizophrenia: A Systematic Review and Meta‐Analysis of Prevalence and Associations and Future Directions

Contopoulos‐Ioannidis

Gianniki

Truong

et al. 2022

PRCP

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Background: A potential link between toxoplasmosis with schizophrenia (SCZ) has been extensively studied over the past 2 decades. Our study was aimed to determine whether, beyond an association, the field is primed for randomized clinical trials of anti-Toxoplasma prophylaxis in Toxoplasma seropositive patients with SCZ.Methods: We performed a methodological appraisal of toxoplasmosis-SCZ association studies, a meta-analysis, and a compilation of claims and pathophysiologic hypotheses. Results:We analyzed 66 studies with 11,540 patients with SCZ and 69,491 controls. For patients with SCZ, 54 studies targeted Toxoplasma-IgG seropositivity, 18 targeted Toxoplasma-IgG serointensity, and 17 targeted Toxoplasma-IgM seropositivity. For SCZ-phenotypes, 26 targeted Toxoplasma-IgG seropositivity, six targeted Toxoplasma-IgG serointensity, and three targeted Toxoplasma-IgM seropositivity. Two-thirds of these studies reported a positive association. Statistically significant associations with SCZ were reported in 31/54 studies, 11/18 studies, and 3/17 studies. Significant associations with SCZphenotypes were reported in 20/26 studies, 2/6 studies, and 0/3 studies, respectively. Toxoplasma-IgG seropositivity increased the odds of SCZ (OR = 1.91; 95% CI: 1.61-2.27). Heterogeneity across studies was large (I 2 = 80.03%). Adjusted analyses for at least age and socioeconomic status/place of residence were done in 17 studies; temporality was addressed only in 4. Conclusion:A large number of observational studies revealed a modest to large association between toxoplasmosis and SCZ. Although important methodological biases were identified, further association studies are unlikely to change this association and are not justified. It is time to test this association in randomized double-blind placebo-controlled clinical trials of first line anti-Toxoplasma prophylaxis in Toxoplasma seropositive patients with SCZ.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Toxoplasmosis and Schizophrenia: A Systematic Review and Meta‐Analysis of Prevalence and Associations and Future Directions

Contopoulos‐Ioannidis

Gianniki

Truong

et al. 2022

PRCP

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“…The innate immune system first produces IL-2 and IFN in response to a T. gondii infection. (37) both acute and persistent To keep IFN-production going, the gondii infection must be under control. These two cytokines set off an immune response that CD4+ and CD8+ T cells mediate.…”

Section: Materials and Methods 1-(32) Women With Breast Cancer Sympto...mentioning

confidence: 99%

Study about the association between toxoplasma and breast cancer in Najaf During 2020

Al-Sharefi¹,

Mahdi²,

AlSaegh³

et al. 2023

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This study was begin from January to December 2020 , to learn where there breast cancer and toxoplasma infection are related By used immunology test results . 2020, to know the association between Toxoplasma infection and breast cancer .by examine immunological test.32 women who had tumors were the subjects of a study conducted at the Al-Sadder Teaching Hospital in Al-Najaf Al-Ashraf , with breast tumor symptom . the mean age of women from 35-45 years ago . X-ray was done at first and sonar to detected the site of tumor and size . Biopsy was taken and sent to the Al- kafeel histopathological laboratory for making block and stain with hemaxlin and eoxin typical Histological change and ductal cancer show with irregular shape of duct mammary gland ,by use H & E method , serological was applied for toxoplasma appear in Five women is positive test for Toxoplasma AB by used special kit . the rest women consider control group . this study was find significant Toxoplasma associated with breast cancer , the case record at first time in Al-Najaf government.

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“…Several infections, such as cytomegalovirus, herpes simplex virus, and parasitic infection by T. gondii , have been noted for interacting with the HLA system and for their association with affective disorders like BPD and SCZ ( Parks et al, 2018 ). SCZ has been linked to several polymorphisms in the major histocompatibility complex (MHC) or the HLA system through several GWAS ( Parks et al, 2018 ). HLA genes are expressed in astrocytes and microglia within the brain, although primarily in microglia ( Tian et al, 2012 ).…”

Section: Potential Mechanisms Of Sars-cov-2 Mediated Mental Disordersmentioning

confidence: 99%

Impact of SARS-CoV-2 on Host Factors Involved in Mental Disorders

et al. 2022

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COVID-19, caused by SARS-CoV-2, is a systemic illness due to its multiorgan effects in patients. The disease has a detrimental impact on respiratory and cardiovascular systems. One early symptom of infection is anosmia or lack of smell; this implicates the involvement of the olfactory bulb in COVID-19 disease and provides a route into the central nervous system. However, little is known about how SARS-CoV-2 affects neurological or psychological symptoms. SARS-CoV-2 exploits host receptors that converge on pathways that impact psychological symptoms. This systemic review discusses the ways involved by coronavirus infection and their impact on mental health disorders. We begin by briefly introducing the history of coronaviruses, followed by an overview of the essential proteins to viral entry. Then, we discuss the downstream effects of viral entry on host proteins. Finally, we review the literature on host factors that are known to play critical roles in neuropsychiatric symptoms and mental diseases and discuss how COVID-19 could impact mental health globally. Our review details the host factors and pathways involved in the cellular mechanisms, such as systemic inflammation, that play a significant role in the development of neuropsychological symptoms stemming from COVID-19 infection.

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HLA typing using genome wide data reveals susceptibility types for infections in a psychiatric disease enriched sample

Cited by 12 publications

References 60 publications

Toxoplasmosis and Schizophrenia: A Systematic Review and Meta‐Analysis of Prevalence and Associations and Future Directions

Toxoplasmosis and Schizophrenia: A Systematic Review and Meta‐Analysis of Prevalence and Associations and Future Directions

Study about the association between toxoplasma and breast cancer in Najaf During 2020

Impact of SARS-CoV-2 on Host Factors Involved in Mental Disorders

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