Hla-Typing in Multiple Sclerosis Sibling Pairs

Ebers, G. C.; Paty, Donald W.; Cr, Stiller; Nelson, Robert F.; Seland, Torrey; Larsen, Bodil

doi:10.1016/s0140-6736(82)91702-0

Cited by 83 publications

(17 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Linkage to the HLA region is supported by many (e.g., refs. 29, 31), but not all (32,33), studies of haplotype sharing in affected sibling pairs. In formal segregation and linkage analysis (34), an excellent fit was obtained for a model with a dominant MS determinant tightly linked to the DR2 haplotype and a second unlinked determinant.…”

Section: Discussionmentioning

confidence: 99%

Primarily chronic progressive and relapsing/remitting multiple sclerosis: two immunogenetically distinct disease entities.

Olerup

Hillert

Fredrikson

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

220

View full text Add to dashboard Cite

HLA class II gene polymorphism was investigated in 100 patients with clinically definite multiple sclerosis (MS) by restriction fragment length polymorphism analysis of Taq I-digested DNA using DRB, DQA, and DQB cDNA probes.Twenty-six patients had primarily chronic progressive MS and 74 had relapsing/remitting MS. The latter group included patients with a secondary progressive evolution of symptoms. Both clinical forms of MS were found to be associated with the DRw15,DQw6 haplotpe. In addition, primarily chronic progressive MS was positively associated with theDQBl restriction fragment pattern seen in DR4,DQw8, DR7,DQw9, and DRw8, DQw4 haplotypes, as well as negatively associated with the Taq I DQBI allelic pattern corresponding to the serological specificity DQw7. Relapsing/remitting MS was positively associated with the DQBI allelic pattern observed in the DRw17,DQw2 haplotype. These three DQB1 alleles are in strong negative linkage disequilibria with DRw15. The two susceptibility markers ofeach clinical form ofMS act additively in determining the genetic susceptibility, as the relative risks for individuals carrying both markers roughly equal the sum of respective risks. Different alleles of the DQB1 locus defined by restriction fragment length polymorphisms contribute to susceptibility and resistance to primarily chronic progressive MS as well as to susceptibility to relapsing/remitting MS (4,5); i.e., the disease has a continuous progressive evolution from onset. It has been proposed that PCP MS and R/R MS may be separate disease entities (6) since they differ with respect to epidemiology (6), age at onset (4, 5, 7), initial symptoms (4, 6), prognosis with regard to degree of disability (4, 7) and to mortality (8), and response to immunosuppression (9 The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.

show abstract

Section: Discussionmentioning

confidence: 99%

Primarily chronic progressive and relapsing/remitting multiple sclerosis: two immunogenetically distinct disease entities.

Olerup

Hillert

Fredrikson

et al. 1989

Proc. Natl. Acad. Sci. U.S.A.

220

View full text Add to dashboard Cite

show abstract

“…Such a hypothesis would require modification to note that the childhood infection would be in teenagers, because young migrants from areas of high incidence tend not to develop the disease ifthey move to areas oflow incidence' 7 The patients were recruited by general practitioners. At the first visit the history was noted and a full examination carried out.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Amantadine in Reducing Relapses in Multiple Sclerosis

Plaut

1987

J R Soc Med

View full text Add to dashboard Cite

show abstract

“…The HLA system has been implicated in the vulnerability for many diseases with an autoimmune component. Many studies have reported an increased frequency of certain HLA antigens in MS patients 25,26 . Some authors have examined the involvement of preferential HLA genes in patients with comorbid BD and MS. Schiffer et al 27 were the fi rst to explore the relation between MS and affective disorders from perspective.…”

Section: Discussionmentioning

confidence: 99%

Bipolar disorder and multiple sclerosis

Ybarra

Moreira

Araújo

et al. 2007

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

-Bipolar disorder may be overrepresented in multiple sclerosis (MS) patients. Although research in this area is limited, studies assessing the nature of this association have focused on genetic aspects, adverse reaction to drugs and brain demyelinating lesions. Herein we report three patients with MS that also presented bipolar disorder. The coexistence of neurological and psychiatric symptoms in most MS relapses highlights the relevance of biological factors in the emergence of mood disorders in these patients.KEY WORDS: multiple sclerosis, bipolar disorder.Transtorno bipolar e esclerose múltipla RESUMO -O transtorno bipolar do humor parece estar super-representado em pacientes com esclerose múl-tipla (EM). Apesar de a pesquisa nessa área ser limitada, estudos acerca da natureza dessa associação têm se concentrado em aspectos genéticos, reações adversas a drogas e lesões desmielinizantes no sistema nervoso central. Relatamos, aqui, três casos de pacientes com EM que também apresentaram transtorno bipolar do humor. A coexistência de sintomas neurológicos e psiquiátricos em grande parte das recaídas de EM reforça a importância de fatores biológicos na gênese dos sintomas afetivos nesses pacientes.PALAVRAS-CHAVE: esclerose múltipla, transtorno bipolar.

show abstract

Hla-Typing in Multiple Sclerosis Sibling Pairs

Cited by 83 publications

References 20 publications

Primarily chronic progressive and relapsing/remitting multiple sclerosis: two immunogenetically distinct disease entities.

Primarily chronic progressive and relapsing/remitting multiple sclerosis: two immunogenetically distinct disease entities.

Effectiveness of Amantadine in Reducing Relapses in Multiple Sclerosis

Bipolar disorder and multiple sclerosis

Contact Info

Product

Resources

About