HLA polymorphism in the murcia population (Spain): in the cradle of the archaeologic Iberians

Muro, Manuel; Marı́n, Luis; Torı́o, Alberto; Moya‐Quiles, María Rosa; Minguela, Alfredo; Rosique-Roman, Juan; Sanchis, Marı́a J; Garcı́a-Calatayud, Marı́a Carmen; García‐Alonso, Ana M.; Álvarez-López, María R.

doi:10.1016/s0198-8859(01)00290-7

Cited by 59 publications

(51 citation statements)

References 32 publications

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“…HLA-A*30 was 8.6% in Blacks, 6.2% in Browns, and 3.2% in Whites. Consistent with these observations, HLA-A*30 is found at higher frequency in African populations (29% in Cameroon and 23% in Mozambique) [18,19] but not in European populations [20,21].…”

Section: Resultssupporting

confidence: 75%

Self-Assessment of Color Categories and Its Relationship with HLA Profiling in Brazilian Bone Marrow Donors

Boquett

Schüler‐Faccini

Jobim

et al. 2015

Biology of Blood and Marrow Transplantation

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The Brazil Ministry of Health maintains a Registry of Bone Marrow Donors that corresponds to approximately 12% of the Bone Marrow Donors Worldwide registry. This registry contains information on ethnicity (by self-assessment of color) and HLA-A, -B, and -DRB1 type. The self-assessment of color tool has been extensively used for admixed population characterization. In this context, Brazil represents a highly admixed population, resulting from 5 centuries of colonization and interbreeding, mainly, but not exclusively, among Native Americans, Europeans, and Africans. Here we evaluated self-assessed skin color and HLA genetic information from 71,291 bone marrow donors of southern Brazil to verify how likely is the HLA profiling correspondence within and between self-assessed color groups. We found that HLA itself was a better ancestry indicator than was self-assessed color. Therefore, self-assessment of color in highly admixed populations, such as that of Brazil, is not indicative of higher correspondence in the HLA profiles within skin color groups.

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Section: Resultssupporting

confidence: 75%

Self-Assessment of Color Categories and Its Relationship with HLA Profiling in Brazilian Bone Marrow Donors

Boquett

Schüler‐Faccini

Jobim

et al. 2015

Biology of Blood and Marrow Transplantation

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“…The group admixture proportions were estimated by the gene identity method [13] [15], Malians [8], Zambians [8], and Senegal-Serere [16]), 6 European (Catalonians [17], Madrid-Spaniards [18], Andalusians [11], Murcians [19], and French [11]), and 6 Amerindians (Tarahumara [20], Mixtec [21], Mixe [21], Yucpa [22], Bari [23], and Warao [11]). To obtain estimates that are as reliable as possible, Chakraborty's method was applied to all possible combinations (180) of one population from each parental group and the averages were reported.…”

Section: Discussionmentioning

confidence: 99%

HLA class I polymorphism in the Cuban population

et al. 2007

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“…In our study we did not analyze HLA-Cw but nevertheless, HLA-B27 is in linkage disequilibrium in our zone with Cw 0102 and 0202 (data not shown) but this linkage disequilibrium is not described with Cw 0701. This indicates that in our population, the association is really with B27 and not by a mistake due to linkage disequilibrium with Cw0701 (27,28). On the other hand, the mentioned study is of an English population and therefore different from the group we studied, which was a Mediterranean population of the south of Spain (29)(30)(31).…”

Section: Discussionmentioning

confidence: 61%

HLA B27 as Predisposition Factor to Suffer Age Related Macular Degeneration

et al. 2009

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To research whether specific alleles HLA class I (HLA-A and HLA-B) and class II (HLA-DR) are risk factors for the development of exudative type of Age Related Macular Degeneration (ARMD), HLA antigens are expressed both in normal and affected eyes with ARMD. We designed a prospective case-controlled study. We recruited 75 patients with choroidal neovascularization predominantly classic or occult, secondary to ARMD, and treated with photodynamic therapy. Two hundred and fifty patients over 55 years old, without ophthalmologic pathology who went to hospital for an analytical routine check were used as control. The analysis of the data shows a significant difference between two groups. Allele HLA-B27 correlated positively with ARMD (p < 0.0113). However, we didn't find alleles negatively associated. Thus HLA-B27 is an allele predisposed to suffer ARMD. Cellular & Molecular Immunology. 2009;6(4):303-307.

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HLA polymorphism in the murcia population (Spain): in the cradle of the archaeologic Iberians

Cited by 59 publications

References 32 publications

Self-Assessment of Color Categories and Its Relationship with HLA Profiling in Brazilian Bone Marrow Donors

Self-Assessment of Color Categories and Its Relationship with HLA Profiling in Brazilian Bone Marrow Donors

HLA class I polymorphism in the Cuban population

HLA B27 as Predisposition Factor to Suffer Age Related Macular Degeneration

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