HLA class I polymorphism in the Cuban population

HLA-B27 and Clinical Features of Acute Anterior Uveitis in Cuba

“…Nevertheless, these authors did not find statistically significant difference between whites and mulattos concerning HLA-B27 allele distribution. 20 The frequency reported in our study is consistent with Ferrer et al's findings. This fact highlights the importance of correlating the presence of this allele as a genetic marker for diagnosis of AAU in each population.…”

“…The genetic background of the Cuban populations has a big influence of Caucasian and African genes and, to a lesser degree, Amerindian and Asiatic genes. 4,5,10 Despite the mixed racial origin of patients studied, the HLA-B27 allele frequency is similar to what is described for most Caucasian populations. 1,3,[11][12][13] Indeed, this frequency is different from those reported in non-Caucasian populations with little contribution to Cuban's genetics origins: 40% in the Turkish population and 44% in Thailand.…”

“…Ferrer et al reveals that HLA-B27 prevalence varies between 1.6 and 0.8% in whites and mulattos, respectively. 20 The mulattos are a group resulting from the admixture between blacks and whites. Nevertheless, these authors did not find statistically significant difference between whites and mulattos concerning HLA-B27 allele distribution.…”

“…1,3 The diversity of the genetic background of Cubans results from the contribution of many distinct haplotypes from various African and European populations (mostly Spaniards) and, to a lesser extent, Amerindians. 4,5 There are several reports in the literature of patients with HLA-B27-associated anterior uveitis from developed countries but similar reports in Cuba and other mixed populations from Latin America are scarce. 6,7 The strength of disease association with HLA-B27 varies markedly among different ethnic populations.…”

HLA-A, -B and -DRB1 allele frequencies in Cyrenaica population (Libya) and genetic relationships with other populations

“…Knowledge of this genetic system is helpful in organ and in haematopoietic stem cell transplantation, vaccine development, and disease association. In anthropological studies, the usefulness of HLA for assessing genetic relationships among populations has been widely used and validated to establish or corroborate migration and admixture patterns [4][5][6]. However, limited information is available on the distribution of HLA alleles in some countries and/or ethnic groups, in particular those from Africa including Libya [7].…”