HLA-A, -B and -DRB1 allele frequencies in Cyrenaica population (Libya) and genetic relationships with other populations

Galgani, Andrea; Mancino, Giorgio; Martínez-Labarga, Cristina; Cicconi, Rosella; Mattei, Maurizio; Amicosante, Massimo; Bonanno, Cesira T.; Sano, Caterina Di; Gimil, Giuma Salem; Salerno, Alfredo; Colizzi, Vittorio; Montesano, Carla

doi:10.1016/j.humimm.2012.10.001

Cited by 21 publications

(10 citation statements)

References 36 publications

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“…At the HLA‐A, ‐B and ‐DRB1 associations, HLA‐A*24:02:01:01‐B*08:01:01‐ DRB1*03:01:01:01 was found to be common in our population and in Tunisians and Libyans . HLA‐A*23:01:01 B*50:01:01 DRB1*07:01:01:01 described in this population was found in another Arabic population from Tunisia …”

Section: Discussionsupporting

confidence: 56%

“…At the HLA-A, -B and -DRB1 associations, HLA-A*24: 02:01:01-B*08:01:01-DRB1*03:01:01:01 was found to be common in our population and in Tunisians (20) and Libyans (21). HLA-A*23:01:01 B*50:01:01 DRB1*07:01:01:01 described in this population was found in another Arabic population from Tunisia (20) Interesting to note that HLA-DRB1*07:01:01:01 and HLA-B*50:01:01 occur on different haplotypes of HLA-A, including A*23:01:01-B*50:01:01-DRB1*07:01:01:01 , also described in Portugal (22), A*02:05:01-B*50:01:01-DRB1* 07:01:01:01 , found in Northwest England (16) and A*02:01:01:01-B*50:01:01-DRB1*07:01:01:01 , found in Tunisia (23).…”

Section: Discussionmentioning

confidence: 46%

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HLA‐A, ‐B, ‐C, ‐DRB1 and ‐DQB1 allele and haplotype frequencies in Saudis using next generation sequencing technique

et al. 2013

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Next generation sequencing (NGS) is a promising technique that can reveal the entire gene sequences and to the highest possible resolution without any phase ambiguities. We have used this technique to investigate the frequencies of HLA-A, -B, -C, -DRB1 and -DQB1 in a Saudi cohort of healthy individuals. We used NGS using the 454 genome sequence (GS) FLX System and Conexio assign atf 454 software to human leukocyte antigen (HLA) genotype eight class I and class II loci. A total of 158 healthy Saudi adults were analyzed. The most frequently observed allele for HLA-A was HLA-A*02:01:01:01 (13.6%); for HLA-B, HLA-B*50:01:01 (15.8%); for HLA-C, HLA-C*06:02:01:01 (18.7%); for HLA-DRB1, HLA-DRB1*07:01:01:01 (26.6%); and for HLA-DQB1, HLA-DQB1*02:01:01 (20.3%). The most common four loci haplotypes in the Saudi population were HLA-A*24:02:01:01-B*08:01:01-C*07:02:01:01-DRB1*03:01:01:01 and HLA-A*23:01:01-B*50:01:01-C*06:02:01:01-DRB1*07:01:01:01.. We have used a highly informative technique for HLA typing of a Saudi healthy cohort to establish allele and haplotype frequencies. These results should prove useful for population studies, disease associations and future planning of the unrelated bone marrow donor registry.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 46%

HLA‐A, ‐B, ‐C, ‐DRB1 and ‐DQB1 allele and haplotype frequencies in Saudis using next generation sequencing technique

et al. 2013

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“…The newly genotyped population samples included (Table ): 95 north Africans from Morocco (Baassi et al, ) and 110 from Libya (Galgani et al, ); 56 Oromo from Asela, Oromia Region, central Ethiopia (Messina et al, ); 148 donors from two Ecuadorian communities of African ancestry living in the Esmeraldas province: 100 along Rio Cayapas and 48 in Viche village (Martínez‐Labarga et al, ; Rickards et al, ); 52 samples from China; 179 Ecuadorian Native Americans: 99 Cayapa Indians (Rickards, Martínez‐Labarga, Lum, De Stefano, & Cann, ) and 80 Tsáchila Indians (Babalini et al, ); 86 individuals from the Ladakh region of northern India; 1,204 Europeans (74 individuals from Albania, 100 Spaniards sampled in Vera and Bejar valleys, Sierra de Gredos, central Spain [Varano et al, ]; 1,030 Italians from different geographical regions [Supporting Information Table S1]), and 203 individuals of European ancestry living in Busselton, Western Australia.…”

Section: Methodsmentioning

confidence: 99%

Concerted variation of the 3′ regulatory region of Ig heavy chain and Gm haplotypes across human continental populations

Frezza

Martínez-Labarga

Giambra³

et al. 2020

American J Phys Anthropol

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Objectives The 3′ regulatory region of the immunoglobulin heavy chain gene (IGH) includes the HS1.2 enhancer displaying length polymorphism with four known variants. The goal of the research was to provide an overview of this variability and of its evolutionary significance across human populations. Materials and Methods We compiled published and original data on HS1.2 polymorphism in 3,100 subjects from 26 human populations. Moreover, we imputed the haplotypic arrangement of the HS1.2 region in the 1000 Genomes Project (1KGP). In this dataset, imputation could also be obtained for the G1m‐G3m allotype by virtue of the precise correspondence between serological types and amino acid (and DNA) substitutions in IGHG1 and IGHG3. Results HS1.2 variant frequencies displayed similar patterns of continental partitioning as those reported in the literature for the physically neighboring IGHG1‐IGHG3 system. The 1KGP data revealed that linkage disequilibrium (LD) can explain the spread of joint HS1.2‐IGHG1‐IGHG3 associations across continents and within continental populations, with stronger LD out of Africa and the features of an evolutionarily stable genomic block with differential expression in lymphoblastoid cell lines. Discussion Strong population structuring involves at least the entire 70 kb genomic region here considered, due to the tight LD which maintained HS1.2, IGHG1, and IGHG3 in nonrandom arrangements. This might be key to better understand the evolutionary path of the entire genomic region driven by immune response capabilities, during the formation of continental gene pools.

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“…They were 60 males and 54 females, all from the Libya Cyrenaica. This study population is representing a defined ethnic group geographical related with other populations from North Africa and Mediterranean areas as recently reported [10]. HCV coinfection was identified in 46 out of 114 children of the study population [9,11].…”

Section: Study Populationmentioning

confidence: 89%

Impact of Human Leukocyte Antigen Polymorphisms in Human Immunodeficiency Virus Progression in a Paediatric Cohort Infected with a Mono-phyletic Human Immunodeficiency Virus-1 Strain

et al. 2014

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HLA-A, -B and -DRB1 allele frequencies in Cyrenaica population (Libya) and genetic relationships with other populations

Cited by 21 publications

References 36 publications

HLA‐A, ‐B, ‐C, ‐DRB1 and ‐DQB1 allele and haplotype frequencies in Saudis using next generation sequencing technique

HLA‐A, ‐B, ‐C, ‐DRB1 and ‐DQB1 allele and haplotype frequencies in Saudis using next generation sequencing technique

Concerted variation of the 3′ regulatory region of Ig heavy chain and Gm haplotypes across human continental populations

Impact of Human Leukocyte Antigen Polymorphisms in Human Immunodeficiency Virus Progression in a Paediatric Cohort Infected with a Mono-phyletic Human Immunodeficiency Virus-1 Strain

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