HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish

Ross, Owen A.; Curran, Martin D.; Rea, Irene Maeve; Hyland, Paul; Duggan, Orla; Barnett, Christopher R.; Annett, Kathryn; Patterson, Chris; Barnett, Yvonne; Middleton, Derek

doi:10.1016/s0047-6374(03)00037-x

Cited by 38 publications

(23 citation statements)

References 22 publications

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“…However, a striking decrease was observed when the aged women (13.1%) were compared to the control women (17.8%). 28 A pivotal role in the innate immune response is also played by NK cells in successful aging. In particular, some studies have showed that decreased NK cell function is associated with an increased incidence of infectious diseases both in aged humans 29 and in mice, 30 highlighting the importance of a well-preserved NK cell function in old age.…”

Section: Listi`et Almentioning

confidence: 99%

HLA and KIR Frequencies in Sicilian Centenarians

Listı́

Caruso

Colonna‐Romano

et al. 2010

Rejuvenation Research

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Several studies suggest that human longevity appears to be linked inextricably with optimal functioning of the immune system, suggesting that specific genetic determinants may reside in loci that regulate the immune response, as human leukocyte antigen (HLA) and killer cell immunoglobulin-like receptor (KIR) genes. It has been suggested that longevity is associated with positive selection of alleles (i.e., HLA-DR11) or haplotypes (i.e., HLA-B8,DR3) that confer resistance to infectious disease(s). On the other hand, the cytolytic activity of natural killer (NK) cells is controlled by activating and inhibitory cell-surface receptors, including KIR. The genetic diversity of the KIR loci with respect to successful aging has been analyzed only in one study performed in the Irish population. Although two KIR genes (2DS3, 2DL5) displayed an initial increased frequency in the aged group, the significance of this association was lost when repeated in a second cohort. We have evaluated by polymerase chain reaction-sequence-specific primers (PCR-SSP) HLA-DRB1 and KIR receptors=HLA ligands frequencies in centenarians and controls from Sicily. Our results demonstrate an increase of the HLA DRB1*18 allele in male centenarians ( p ¼ 0.0266, after Bonferroni correction). Concerning KIR, no significant difference was observed after Bonferroni correction. However, our findings suggest that HLA=KIR=longevity associations are population specific, being heavily affected by the population-specific genetic and environmental history. This kind of study is important to better understand aging and longevity, hence enhancing the planning of antiaging strategies.

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Section: Listi`et Almentioning

confidence: 99%

HLA and KIR Frequencies in Sicilian Centenarians

Listı́

Caruso

Colonna‐Romano

et al. 2010

Rejuvenation Research

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“…In nonagenarians/centenarians from Ireland Finland and Japan mtDNA haplogroups and longevity are also associated (Niemi et al, 1998;Tanaka et al, 1998;De Benedictis et al, 1999;Ross et al, 2001;Salvioli et al, 2006a) Interesting conclusions emerge from a comprehensive/critical analysis of the available data on the genetics of centenarians Capri et al, 2006;Salvioli et al, 2006a;Christensen at al., 2006;Candore et al, 2006a): In most of the cases we cannot decide which of the two alternatives is true, but in any case these considerations are crucial as regards replication studies, that is studies that aim to confirm in another population the associations between genetic loci and traits found in one population.…”

Section: The Genetics Of Human Longevity and The Results Of Associatimentioning

confidence: 99%

Human longevity within an evolutionary perspective: The peculiar paradigm of a post-reproductive genetics

Capri¹,

Salvioli²,

Monti³

et al. 2008

Experimental Gerontology

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“…A series of experimental evidence have been published suggesting that some mtDNA haplogroups are associated with longevity (Tanaka et al 1998;De Benedictis et al 1999;Ross et al 2001;Niemi et al 2003), as well as with mitochondrial diseases (Torroni et al 1997;Reynier et al 1999), and complex diseases (Wallace 2005). In particular, in northern Italians, Irish and Finnish, haplogroup J is over-represented in long-living people and centenarians (De Benedictis 1999;Ross et al 2001;Niemi et al 2003), suggesting a role for this mtDNA variant in longevity (Santoro et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Mitochondria and Neurodegeneration

et al. 2007

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Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. However, despite the evidence of morphological, biochemical and molecular abnormalities in mitochondria in various tissues of patients with neurodegenerative disorders, the question "is mitochondrial dysfunction a necessary step in neurodegeneration?" is still unanswered. In this review, we highlight some of the major neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis and Huntington's disease) and discuss the role of the mitochondria in the pathogenetic cascade leading to neurodegeneration.

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HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish

Cited by 38 publications

References 22 publications

HLA and KIR Frequencies in Sicilian Centenarians

HLA and KIR Frequencies in Sicilian Centenarians

Human longevity within an evolutionary perspective: The peculiar paradigm of a post-reproductive genetics

Mitochondria and Neurodegeneration

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