Hla Haplotype A1 B8 Dr3 as a Risk Factor for Hiv-Related Disease

Steel, C. M.; Beatson, Dianne; Cuthbert, R. J. G.; Morrison, Heather; Ludlam, C. A.; Peutherer, J F; Simmonds, Peter; Jones, Mike

doi:10.1016/s0140-6736(88)92009-0

Cited by 191 publications

(73 citation statements)

References 19 publications

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“…In the patients studied by Steel et al [5], the HLA haplotype Al B8 DR3 was weakly associated with an increased risk of seroconversion and our data for Italian population [6] suggested a possible role of class I HLA antigens in susceptibility to HIV infection.…”

Section: Introductionsupporting

confidence: 59%

“…At present recent data suggest that several HLA alleles influence both the rapidity and the type of HIV-1 infection [3][4][5][6][7][8][9][10][11][12]. We have much less information about HLA-linked genetic control of HIV susceptibility.…”

Section: Introductionmentioning

confidence: 99%

“…Some information in this field has come from the study of HLA phenotypedistributionsofHIV+ and HIV~ haemophiliac patients exposed to a single batch of factor VIII contaminated with HIV [5] or exposed for the same period of time to comparable amounts and batches of presumably infectious clotting factor concentrates [6]. In the patients studied by Steel et al [5], the HLA haplotype Al B8 DR3 was weakly associated with an increased risk of seroconversion and our data for Italian population [6] suggested a possible role of class I HLA antigens in susceptibility to HIV infection.…”

Section: Introductionmentioning

confidence: 99%

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HLA-associated susceptibility to HIV-1 infection

Gavarini¹,

Scorza²,

Lazzarin³

et al. 1992

Clinical and Experimental Immunology

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SUMMARYWe studied HLA antigen distribution of 50 heterosexual partners of HIV+ drug abusers with more than I year of sexual exposure to HIV, 36 children born to seropositive mothers and 61 haemophiliac patients exposed to presumably infectious clotting factor concentrates. B52 and B44 antigens were associated with HIV resistance while B51 was associated with HIV susceptibility. Forty-nine HIV+ drug abusers, spouses of heterosexual partners studied and 25 HIV+ mothers of the children were also typed. DRl 1 phenotype was associated with infectiousness of HIV+ subjects. Our data suggest that the HLA region controls susceptibility to infection with HIV and infectiousness of HIV+ subjects in different risk groups.

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Section: Introductionsupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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HLA-associated susceptibility to HIV-1 infection

Gavarini¹,

Scorza²,

Lazzarin³

et al. 1992

Clinical and Experimental Immunology

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“…[8][9][10] Recently, for some viral infections, associations have been reported between HLA polymorphism and the clinical outcome of infected patients. [11][12][13][14] However, it remains uncertain whether HLA polymorphisms are involved in the pathogenesis of liver injury in chronic HCV infection.…”

mentioning

confidence: 99%

Influence of HLA haplotypes on the clinical courses of individuals infected with hepatitis C virus

et al. 1998

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“…The DRl antigen was associated with an increased risk of rapid progression from an asymptomatic state to AIDS [8]. Especially the Caucasian haplotype Al B8 DR3 was consistently found to be associated with rapid progression to AIDS [9] and rapid decline in CD4 helper cells [10]. Complement C4 null alleies [11] and several ancestral haplotypes that carry them have also been shown to be Correspondence: F. Hentges MD, Department of Immuno-Allergology.…”

Section: Introductionmentioning

confidence: 99%

Prolonged clinically asymptomatic evolution after HIV-1 infection is marked by the absence of complement C4 null alleles at the MHC

Hentges

Hoffmann

Araújo

et al. 1992

Clinical and Experimental Immunology

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SUMMARYThe length of time after which persons infected with HIV-1 progress to AIDS is variable. Certain alleies at the MHC have been shown to influence negatively the clinical outcome of HIV-1-infected persons and to be associated with special clinical manifestations. We investigated the MHC class I, class II and class III antigens in 54 Caucasian HIV-1-infected persons. The MHC profile of individuals with a prolonged period before AIDS is marked by a lower frequency of C4 null alleies.

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Hla Haplotype A1 B8 Dr3 as a Risk Factor for Hiv-Related Disease

Cited by 191 publications

References 19 publications

HLA-associated susceptibility to HIV-1 infection

HLA-associated susceptibility to HIV-1 infection

Influence of HLA haplotypes on the clinical courses of individuals infected with hepatitis C virus

Prolonged clinically asymptomatic evolution after HIV-1 infection is marked by the absence of complement C4 null alleles at the MHC

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