HLA-associated susceptibility to HIV-1 infection

Gavarini, Fabio; Scorza, Raffaella; Lazzarin, Adriano; Marchini, Maurizio; Zarantonello, M; D’Arminio, Antonella; Marchisio, Paola; Plebani, A; Luzzati, Roberto; Costigliola, Paolo

doi:10.1111/j.1365-2249.1992.tb06407.x

Cited by 31 publications

(7 citation statements)

References 25 publications

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“…This observation contradicts a previous study in which this allele was not associated with either slower or faster AIDS progression. 50 The association of the B52 HLA-B*52 associated with non-progression to AIDS SLM Teixeira et al antigen with resistance to HIV was first described in 1992 by Fabio et al, 51 but since then there has been no other study corroborating this finding. Recently, HLA-B*52 was linked to a strong effect on viral load during early time points but had no significant effect on the long-term control of HIV-1.…”

Section: Discussionmentioning

confidence: 89%

Association of the HLA-B*52 allele with non-progression to AIDS in Brazilian HIV-1-infected individuals

et al. 2014

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Software to analyze multi-locus genotype data for entire populations is useful for estimating haplotype frequencies, deviation from Hardy-Weinberg equilibrium and patterns of linkage disequilibrium. These statistical results are important to both those interested in human genome variation and disease predisposition as well as evolutionary genetics. As part of the 13 th International Histocompatibility and Immunogenetics Working Group (IHWG), we have developed a software framework (PyPop). The primary novelty of this package is that it allows integration of statistics across large numbers of data-sets by heavily utilizing the XML file format and the R statistical package to view graphical output, while retaining the ability to inter-operate with existing software. Largely developed to address human population data, it can, however, be used for population based data for any organism.

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Section: Discussionmentioning

confidence: 89%

Association of the HLA-B*52 allele with non-progression to AIDS in Brazilian HIV-1-infected individuals

et al. 2014

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“…Whether B44-restricted CTL responses to EW9 influence disease progression is not clear yet. Results from earlier analyses investigating B44 as a protection or risk factor for HIV-1 infection have been ambiguous (8,9,34). A negative influence on drug efficacy has been demonstrated for both HLA-B44 (A. Saitoh, C. Powell, T. Fenton, C. Fletcher, and S. Spector, oral abstract 51d presented at the 12th Conference on Retroviruses and Opportunistic Infections, 2005) and the E35D substitution (1,25).…”

Section: Discussionmentioning

confidence: 99%

Dual Selection Pressure by Drugs and HLA Class I-Restricted Immune Responses on Human Immunodeficiency Virus Type 1 Protease

Mueller

Schaetz

Eismann

et al. 2007

J Virol

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“…The protective effect of this allele was reported in many studies. 21 This study has some limitations.…”

Section: Discussionmentioning

confidence: 91%

HLA-B*44 allele associated with clinical parameters in HIV-1 infected Moroccan cohort

et al. 2019

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Background: The human leukocyte antigen-B*44 (HLA-B*44) allele has been reported to have promising results in the control of human immunodeficiency virus-1 (HIV-1) infection and associated with protection against HIV-1 disease progression. In the Moroccan HIV-1 infected patients, the contribution of this allele has not been established. This study aimed to evaluate the distribution of HLA-B*44 allele among HIV-1-infected in Morocco. Additionally, investigate HLA-B*44 allele association with demographical and HIV clinical parameters.Methods: One hundred and sixty-seven HIV-1 infected, antiretroviral naive individuals were enrolled in this study. The HLA-B*44 allele screening was performed using the PCR amplification.Results: Of the 167 individuals genotyped, 26 (16%) of them expressing the HLA-B*44 allele. Clinical stages at diagnosis, median pre-treatment HIV viral load (pVL) and CD4 T cell counts differ significantly (p = 0.0001, p=0.001 and p=0.0001 respectively) between the patients who had been expressing the HLA-B*44 allele and patients who had not been expressing this allele. The presence of HLA-B*44 allele was significantly associated with pVL and CD4 T cell counts (p=0.004 and p=0.0001 respectively). The bivariate analysis has showed that the expression of the HLA-B*44 allele was strongly associated with advanced HIV infection (Odd ratio (OR) 0.12 (95% confidence interval (CI) 0.04-0.37), p=0.0001).Conclusions: Author have described for the first time in Morocco the association of the HLA-B*44 allele with the clinical parameters of HIV infection. These results expand the knowledge of the distribution and effect of this allele in the Moroccan population.

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HLA-associated susceptibility to HIV-1 infection

Cited by 31 publications

References 25 publications

Association of the HLA-B*52 allele with non-progression to AIDS in Brazilian HIV-1-infected individuals

Association of the HLA-B*52 allele with non-progression to AIDS in Brazilian HIV-1-infected individuals

Dual Selection Pressure by Drugs and HLA Class I-Restricted Immune Responses on Human Immunodeficiency Virus Type 1 Protease

HLA-B*44 allele associated with clinical parameters in HIV-1 infected Moroccan cohort

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