HLA genotypes in turkish patients with myasthenia gravis: Comparison with multiple sclerosis patients on the basis of clinical subtypes and demographic features

A Network-Based Method for Predicting Disease-Causing Genes

“…This protein is part of the HLA class I heavy chain paralogs, which play a central role in the immune system and are expressed in nearly all cells. The linkage between HLA and MG is supported by previous studies (Donmez et al, 2004;Huang et al, 1999;Vandiedonck et al, 2005). The second highest ranking protein was cAMP-dependent protein kinase catalytic subunit alpha isoform 1 (PRKACA).…”

The association of HLA-DQA1*0401 and DQB1*0604 with thymomatous myasthenia gravis in northern Chinese patients

“…Previous studies have reported an association with the HLA-A1, B8, DR3, DQA1*05, DQB1*0201 haplotype in MG with thymic hyperplasia [7,32,33]. Our study suggests that DQB1*0501 provides a protective effect for patients with thymic hyperplasia, and is not found in predisposing alleles in this subgroup.…”

“…The general consensus is that both genetic and environmental components play important roles in pathogenesis [5,6]. The known HLA associations with B8,A1, DR3 and DQ2 antigens in early-onset MG [7,8] differs in various populations, whereas Niks et al [9] describe a strong association of MuSK antibody positive MG and HLA DR14-DQ5 in Caucasians. In contrast, the presence of DQA1*0103 and DQB1*06 has been shown to be negatively associated with MG [10,11].…”

HLA-DQ Polymorphism in Turkish Patients With Myasthenia Gravis

“…The frequently noted association of MG with ancestral DR3 haplotype, which was also recently applied to functional approaches for treatment of MG [29], was confirmed recently in the Turkish population [22]. Our data have extended this association to DQ loci with DQA and DQB alleles as the probably DR3-linked DQ2 alleles (DQA1 ‫ء‬ 02 or ‫ء‬ 0501 with DQB1 ‫ء‬ 02) are increased in MG in the Turkish population also (33.3% vs 22%, OR: 1.8).…”

“…A recent study has investigated genetic susceptibility of the Turkish population to MG by serology. However, DQ genes have not been evaluated in this study [22]. Based on these findings, we screened 132 generalized MG patients preferably for DQA1 and DQB1 polymorphisms and evaluated the associations of DQ genes in selected subgroups of MG.…”