HLA genes of Aleutian Islanders living between Alaska (USA) and Kamchatka (Russia) suggest a possible southern Siberia origin

Moscoso, Juan; Crawford, Michael H.; Vicário, José L.; Zlojutro, Mark; Serrano-Vela, Juan Ignacio; Reguera, Raquel; Arnaiz‐Villena, Antonio

doi:10.1016/j.molimm.2007.07.024

Cited by 25 publications

(27 citation statements)

References 39 publications

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“…AMOVA was performed to estimate the total genetic structure among the BBJ, Kelantan, Minangkabau, and Rawa Malays based on the variance of gene frequencies. The HLA data were also compared with that of several populations obtained from http://www.allelefrequencies.net (accessed February 8, 2008) and from previously published papers [25][26][27][28][29][30][31][32][33].…”

Section: Discussionmentioning

confidence: 99%

HLA polymorphism in six Malay subethnic groups in Malaysia

et al. 2009

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Section: Discussionmentioning

confidence: 99%

HLA polymorphism in six Malay subethnic groups in Malaysia

et al. 2009

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“…Principal Components Analysis (PCA) for 38 populations with HLA-B data available was performed using the IBM SPSS Statistics 19 software ( IBM Corporation, Armonk, NY, USA ) to analyse the distribution of HLA-B alleles in human groups of the proposed ancestries, Figure 1 . PCA included population data of Ireland [20], NW of England [61], Germany [62], Austria [63]; Spain, Italy, United Kingdom [64], France [65], Gypsy from Andalucía (Spain; data collected by López-Nevot et al ) [14], Azores Terceira Island [66], Forro from São Tomé Island [67], Beti from Cameroon [68], Bandiagara from Mali, Lusaka from Zambia, Luo and Nandi from Kenia [69], Mandeka from Senegal [70], Guinea Bissau [71], Aleut from Bering Island (Russia) [72], center of Japan [73], a cord blood bank of Tzu Chi Foundation (Taiwan) [74], Han from southern China [60], north India [75], Kensiu from Malasya [76], Kinh from Vietnam [77], Tarahumara from northern Mexico [17], Native Americans from Gila River (USA) [78], Yu’pik from Alaska (USA) [79], Mixtec, Zapotec, and Mixe from Oaxaca (Mexico) [16], Seri from Sonora (Mexico) [80], Navajo from New Mexico (USA) [81], Uro from Titikaka Lake (Peru) [82], and Toba from Rosario (Argentina; data collected by Cintia Marcos et al ) [14]. Also, two admixed populations from Mexico were included: a “Mexican Mestizo” sample [83] and a sample from Guadalajara City, western Mexico [23].…”

Section: Methodsmentioning

confidence: 99%

HLA Class I and Class II Conserved Extended Haplotypes and Their Fragments or Blocks in Mexicans: Implications for the Study of Genetic Diversity in Admixed Populations

Zúñiga

Barquera³

et al. 2013

PLoS ONE

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Major histocompatibility complex (MHC) genes are highly polymorphic and informative in disease association, transplantation, and population genetics studies with particular importance in the understanding of human population diversity and evolution. The aim of this study was to describe the HLA diversity in Mexican admixed individuals. We studied the polymorphism of MHC class I (HLA-A, -B, -C), and class II (HLA-DRB1, -DQB1) genes using high-resolution sequence based typing (SBT) method and we structured the blocks and conserved extended haplotypes (CEHs) in 234 non-related admixed Mexican individuals (468 haplotypes) by a maximum likelihood method. We found that HLA blocks and CEHs are primarily from Amerindian and Caucasian origin, with smaller participation of African and recent Asian ancestry, demonstrating a great diversity of HLA blocks and CEHs in Mexicans from the central area of Mexico. We also analyzed the degree of admixture in this group using short tandem repeats (STRs) and HLA-B that correlated with the frequency of most probable ancestral HLA-C/−B and -DRB1/−DQB1 blocks and CEHs. Our results contribute to the analysis of the diversity and ancestral contribution of HLA class I and HLA class II alleles and haplotypes of Mexican admixed individuals from Mexico City. This work will help as a reference to improve future studies in Mexicans regarding allotransplantation, immune responses and disease associations.

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“…The Amerindian group includes tribes from the following linguistic families: Macro-Mixteco (Mixtecans and Zapotecans), Macro-Maya (Mixe), Macro-Yuma (Seris), Chibcha (Arsario, Kogi, Arhuaco and Cayapa), Ge Pano Caribe (Xavantes, Mataco and Toba) and others (Swadest, 1959;Ruhlen, 1991). DNA extraction and HLA typing was done as explained in (Moscoso, 2008) statistical analyses were performed as explained in (Vargas-Alarcon, 2007). In short, statistical analysis was performed with Arlequin v1.1 software provided by Excoffier and Slatkin (Excoffier, 1995).…”

Section: Immunol Invest Downloaded From Informahealthcarecom By Univmentioning

confidence: 99%

HLA genes in Wayu Amerindians from Colombia

Silvera

Vargas‐Alarcón

Areces

et al. 2010

Immunological Investigations

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Amerindians origins and prehistory are still debated. HLA profile is different to all other World populations, although they have particular alleles in common with Asians, Australians and Pacific Islanders. In the present work, HLA-A, -B, -DRB1, -DQB1 alleles have been studied in Wayu Amerindians from Colombia. HLA alleles haplotypes, genetic distances and NJ dendrograms were calculated by Arlequin and DISPAN software. Only a few both class I and class II alleles have been observed. Most common extended haplotypes include: A*24-B*51-DRB1*0403-DQB1*0302, A*2-B*15-DRB1*1602-DQB1*0301, A*2-B*35-DRB1*0407-DQB1*0302, but also A*68-B*15-DRB1*0403-DQB1*0302. No trace of Caucasoid or Negroid admixture is detected. The Wayu HLA profile is typical from Amerindians and shows how languages and genes do not correlated particularly in this case (i.e., Wayu closest HLA genetic group is North Argentinian Guarani group). Results obtained in this work may be useful for future transplant programs and also for HLA linked diseases and individualized pharmacogenetics.

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HLA genes of Aleutian Islanders living between Alaska (USA) and Kamchatka (Russia) suggest a possible southern Siberia origin

Cited by 25 publications

References 39 publications

HLA polymorphism in six Malay subethnic groups in Malaysia

HLA polymorphism in six Malay subethnic groups in Malaysia

HLA Class I and Class II Conserved Extended Haplotypes and Their Fragments or Blocks in Mexicans: Implications for the Study of Genetic Diversity in Admixed Populations

HLA genes in Wayu Amerindians from Colombia

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