HLA genes in Southern Tunisians (Ghannouch area) and their Relationship with other Mediterraneans

Hajjej, Abdelhafidh; Hmida, Slama; Kâabi, H.; Dridi, A.; Jridi, A.; Gaaled, A. El; Boukef, K.

doi:10.1016/j.ejmg.2005.01.001

Cited by 36 publications

(55 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This haplotype was found with a frequency similar in Tunisians (HF: 7.9%) [33] but lower in Moroccans (HF: 1.39%) [12] and in Turks (HF: 2.0%) [28].…”

Section: Hla-a -B and -Drb1 Haplotype Frequencymentioning

confidence: 77%

“…HLA-B ⁄ 50 showed higher frequencies compared to other Mediterranean populations [12,14,23,27,31,40]; this allele is commonly observed in Arab populations [14,23,31], and in Tunisian Berbers (15.7%) [39]. HLA-B ⁄ 51, common in Mediterranean populations [23,33], is significantly higher in the Cyrenaica population (p < 0.05) than Tunisian Berbers (2.9%) [39]. The frequency of HLA-B ⁄ 35 (10.2%) was lower com- pared to other Mediterranean populations [23,26,30].…”

Section: Hla Allele Frequenciesmentioning

confidence: 92%

“…For HLA-A/HLA-B, two haplotypes presented a frequency higher than 2%: A ⁄ 02:01:01:01-B ⁄ 07:02:01 and A ⁄ 23: 01:01-B ⁄ 50:01:01 (both 2.97%). These haplotypes were found to be most frequent in Moroccans (HF: 1.59%) [12] and Tunisians (HF: 6.7%) [33].…”

Section: Hla-a -B and -Drb1 Haplotype Frequencymentioning

confidence: 96%

“…The frequency of this haplotype in the Cyrenaica population is higher compared to other North African populations, such as Tunisians (HF: 1.8%) [13] and Tunisians Ghannouch area (HF: 2.5%) [33].…”

Section: Hla-a -B and -Drb1 Haplotype Frequencymentioning

confidence: 99%

“…Other common allelic groups found in the study population are HLA-DRB1 ⁄ 07 (16.9%), DRB1 ⁄ 04 (15.7%) and DRB1 ⁄ 03 (15.3%). By comparing HLA-DRB1 alleles in Cyrenaica with other North African populations [23,33,43], we observed a higher frequency for HLA-DRB1 ⁄ 13:02:01 allele (9.3%), while HLA-DRB1 ⁄ 07:01:01:01 (16.9%) showed a frequency similar to Moroccans (16.1%) [32] but lower than Tunisians (28.6%) [33]. HLA-DRB1 ⁄ 03:01:01:01 (13.6%) was found with a frequency similar to those reported in Algerians (13.8%) [43] but lower than in Tunisians (19.5%) [33].…”

Section: Hla Allele Frequenciesmentioning

confidence: 99%

See 4 more Smart Citations

HLA-A, -B and -DRB1 allele frequencies in Cyrenaica population (Libya) and genetic relationships with other populations

et al. 2013

View full text Add to dashboard Cite

“…This haplotype was found with a frequency similar in Tunisians (HF: 7.9%) [33] but lower in Moroccans (HF: 1.39%) [12] and in Turks (HF: 2.0%) [28].…”

Section: Hla-a -B and -Drb1 Haplotype Frequencymentioning

confidence: 77%

Section: Hla Allele Frequenciesmentioning

confidence: 92%

Section: Hla-a -B and -Drb1 Haplotype Frequencymentioning

confidence: 96%

Section: Hla-a -B and -Drb1 Haplotype Frequencymentioning

confidence: 99%

Section: Hla Allele Frequenciesmentioning

confidence: 99%

See 3 more Smart Citations

HLA-A, -B and -DRB1 allele frequencies in Cyrenaica population (Libya) and genetic relationships with other populations

et al. 2013

View full text Add to dashboard Cite

Association Study Identified HLA‐DQA1 as a Novel Genetic Risk of Systemic Lupus Erythematosus‐Associated Pulmonary Arterial Hypertension

Qian,

Chen,

Yang

et al. 2023

Arthritis & Rheumatology

View full text Add to dashboard Cite

ObjectivePulmonary arterial hypertension (PAH) is severe complication of systemic lupus erythematosus (SLE). However, the genetic signatures of SLE‐associated PAH have not been well studied. We aimed to identify genetic variants implicated in SLE‐associated PAH susceptibility within the major histocompatibility complex (MHC) region and assess the contribution to clinical outcomes.Methods172 SLE‐associated PAH patients confirmed by right heart catheterization, 1303 SLE patients without PAH and 9906 healthy controls were included. Deep sequencing of the MHC region was performed to identify alleles, single‐nucleotide polymorphisms and amino acids. We compared SLE‐associated PAH patients with SLE patients without PAH and healthy controls. Clinical association study was conducted to explore the contribution to phenotypes.ResultsA total of 19881 genetic variants were identified within the MHC region. HLA‐DQA1*03:02 was identified as a novel genetic variant associated with SLE‐associated PAH in the discovery cohort (P=5.68×10‐12) and authenticated in an independent replication cohort (P=1.30×10‐9). The strongest associated amino acid position was mapped to HLA‐DQα1 in the region affecting MHC/peptide‐CD4+ T‐cell receptor affinity and antigen binding. Clinical association study demonstrated that SLE‐associated PAH patients with HLA‐DQA1*03:02 had significantly lower rates of target role achievement (P=0.005) and survival (P=0.04).ConclusionThis study, based on the largest cohort of SLE‐associated PAH, is the first to investigate MHC region genetic variants contribute to SLE‐associated PAH susceptibility. HLA‐DQA1*03:02 is a novel genetic risk factor and a prognostic factor in SLE‐associated PAH. SLE patients with this allele require regular monitoring and careful follow‐up for early diagnosis and interventions for potential PAH.This article is protected by copyright. All rights reserved.

show abstract

Minor histocompatibility antigens HA‐8 and PANE1 in the TUNISIAN population

Said¹,

Sellami²,

Kâabi³

et al. 2022

Molec Gen & Gen Med

View full text Add to dashboard Cite

Background Minor histocompatibility antigens (mHAgs) are endogenous immunogenic peptides initially identified due to complications detected in several contexts of HLA geno‐identical hematopoietic stem cell transplantation (HSCT). In this study, we chose to examine the molecular polymorphism of the mHAgs HA‐8 and PANE1 in the Tunisian population. Material and Methods This study was conducted on 150 healthy and unrelated individuals. The DNA extraction and Sequence‐Specific Primers PCR (PCR‐SSP) methods were used for the molecular genotyping of the selected SNPs: PUM3 (rs2173904) and CENPM (rs5758511). Results Our results show that, 94% of Tunisians are carriers of the PANE1R allele (immunogenic variant of the PANE1 mHAg) and 68% of Tunisians are carriers of the HA‐8R allele (immunogenic variant of the HA‐8 mHAg). Furthermore, this study shows that about 5% of the Tunisians are carrier of the PANE1R antigen and its HLA molecule of presentation (the PANE1R/HLA‐A*0301 combination). However, only 2% of Tunisians are carrier of the HA‐8R/HLA‐A*0201 combination, that is, the HA8 immunogenic variant and its specific HLA molecule of presentation. Conclusion Our results are close to those reported in Caucasian, Asiatic, and African populations, this may be explained by the historical events experienced by Tunisia for millennia. These results could be used for further clinical and anthropological studies.

show abstract

HLA genes in Southern Tunisians (Ghannouch area) and their Relationship with other Mediterraneans

Cited by 36 publications

References 23 publications

HLA-A, -B and -DRB1 allele frequencies in Cyrenaica population (Libya) and genetic relationships with other populations

HLA-A, -B and -DRB1 allele frequencies in Cyrenaica population (Libya) and genetic relationships with other populations

Association Study Identified HLA‐DQA1 as a Novel Genetic Risk of Systemic Lupus Erythematosus‐Associated Pulmonary Arterial Hypertension

Minor histocompatibility antigens HA‐8 and PANE1 in the TUNISIAN population

Contact Info

Product

Resources

About