HLA-G Polymorphisms and Allele Frequencies in Caucasians

Ven, Katrin van der; Skrablin, S.; Engels, Gudrun; Krebs, D.

doi:10.1016/s0198-8859(98)00021-4

Cited by 62 publications

(28 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10 The decreasing allelic prevalence with increasing geographic distance from Spain is consistent with a northwestward dissemination of the mutation through migration and admixture of populations (Table 3). 1 The absence of the G*0105N allele in this study, contrasting with the frequency described in Spanish population, corroborates previous studies that suggested a certain degree of genetic isolation of Portuguese. 11 In addition, HLA-A*30, found in 2% of Portuguese whites, 12 was not present in these samples.…”

Section: Hla-g -A -Cw Haplotype Frequenciessupporting

confidence: 90%

HLA-G genetic polymorphism in 57 Portuguese white families studied by PCR-RFLP and PCR-SSOP

Alvarez

Santos²,

Martinho³

et al. 1999

Transplantation Proceedings

View full text Add to dashboard Cite

Section: Hla-g -A -Cw Haplotype Frequenciessupporting

confidence: 90%

HLA-G genetic polymorphism in 57 Portuguese white families studied by PCR-RFLP and PCR-SSOP

Alvarez

Santos²,

Martinho³

et al. 1999

Transplantation Proceedings

View full text Add to dashboard Cite

“…Frequencies of the different HLA-G alleles vary between ethnic populations. The most frequent are alleles of the HLA-G*01:01 group, which comprise 50-60% in Caucasian and Japanese populations [64,65] and about 80% in some African populations [66]. HLA-G has a higher number of SNPs in its noncoding region, including a promoter region at 5'UTR (untranslated region) and at 3'UTR.…”

Section: Functional Impact Of Hla-g Polymorphismmentioning

confidence: 99%

Role of HLA-G and other immune mechanisms in pregnancy

et al. 2013

View full text Add to dashboard Cite

Pregnancy loss (abortion) and pre-eclampsia represent the most common disorders in pregnant women. Besides infection, there are anatomical, endocrinological, genetic and immunological factors that can induce pregnancy disorders. Because the exact mechanisms of physiological pregnancy maintenance are still not clearly understood, the search for genes and proteins fulfilling this role is still in progress. One of the immune molecules that plays a beneficial role in pregnancy is the nonclassical HLA-G molecule. The molecule is mainly expressed on trophoblast cells in the foetal placenta and induces the immune tolerance of the foetus via its interaction with inhibitory receptors on maternal NK cells and CD8+ T lymphocytes. In relation to pregnancy disorders, associations between HLA-G polymorphism, HLA-G level and HLA-G function were described. Thus, the HLA-G molecule can be used as a new diagnostic marker and, potentially, for the future therapy of pregnancy disorders.

show abstract

“…There is evidence to suggest that the tissue expression of HLA-G may be influenced by genetic polymorphisms on the HLA-G gene (23,24). In particular, a HLA-G insertion (Ins)/ deletion (Del) polymorphism (14 bp in exon 8 of the rs16375 gene) has been suggested to play a role in mRNA stability which affects HLA-G protein expression (25,26).…”

Section: Introductionmentioning

confidence: 99%