HLA-G genetic polymorphism in 57 Portuguese white families studied by PCR-RFLP and PCR-SSOP

Alvarez, Manuela; Santos, P. Marques Dos; Martinho, Antonio C.; Simões, Otília; Abade, Augusto; Breda-Coimbra, Henriqueta

doi:10.1016/s0041-1345(99)00179-7

Cited by 13 publications

(6 citation statements)

References 13 publications

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“…G*01:01:01:01 in our data had relatively lower frequency than those of European and African, and G*01:04:01 had higher frequency than those of most populations. G*01:01:05, G*01:01:06, G*01:01:07, G*01:01:09, G*01:02, G*01:04:04 and G*01:07 alleles, described only in a few reports, were also not observed in the present study (Karhukorpi et al, 1996;Hviid et al, 1997;Suarez et al, 1997;van der Ven et al, 1998;Alvarez et al, 1999;Ishitani et al, 1999;Matte et al, 2000;Abbas et al, 2004;Hviid, 2006;Castelli et al, 2007;Lin et al, 2007). Because there have been not many reports on the data of HLA-G frequencies at a high-resolution level from worldwide populations and each study was performed at different time, it is difficult to compare the exact frequencies in the populations or ethnic groups.…”

Section: Discussioncontrasting

confidence: 57%

“…The HLA-G allele has relatively limited polymorphism, and low variability has been observed in different populations (Karhukorpi et al, 1996;Hviid et al, 1997;Suarez et al, 1997;van der Ven et al, 1998;Alvarez et al, 1999;Ishitani et al, 1999;Matte et al, 2000;Abbas et al, 2004;Hviid, 2006;Castelli et al, 2007;Lin et al, 2007;Rahimi et al, 2010). Caucasian, African and Asian populations have much less sequence variations within the HLA-G locus than other classical HLA loci, which are known as the most polymorphic loci in the human genome.…”

Section: Introductionmentioning

confidence: 99%

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Allele frequencies of human leukocyte antigen‐G in a Korean population

Park

Kim

Kwon

et al. 2011

Int J Immunogenetics

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The human leukocyte antigen (HLA)-G is a nonclassical major histocompatibility complex class I molecule with relatively limited polymorphism. The differences in allele frequency according to ethnicity and country have not been studied enough, so far. Therefore, fundamental data including allele frequencies and polymorphism are needed for studies on immunological function of HLA-G in each population. We investigated allele frequencies and 14-bp polymorphism of the HLA-G in Koreans. HLA-G alleles and 14-bp polymorphisms were determined by sequence-based typing analysis of exons 2-4 and polymerase chain reaction of exon 8 in 200 unrelated individuals. Genotyping analysis identified eight different HLA-G alleles, which indicates that the Korean population presents limited HLA-G allelic polymorphism. HLA-G*01:01:01:01 and G*01:04:01 were frequent alleles (42.5% and 34.0%), and allelic frequencies were similar to those of other Asian populations. The 14-bp deletion alleles are higher (78%) in Koreans, although the frequencies of the 14-bp insertion/deletion polymorphism have been known to be nearly equal in many Caucasian populations. HLA-G*01:01:08 was reported strong linkage disequilibrium with the 14-bp deletion in a previous report; the same allele was accompanied with 14-bp insertion in our study. There are a few studies investigating allele frequencies, and most of them were studied before high-resolution method era. This is the first study regarding HLA-G genotypes in Korean, which were identified by high-resolution method. From this study, we identified HLA-G frequencies of a Korean population and expect this study could help further investigations for immunological and clinical implications of HLA-G.

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Section: Discussioncontrasting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Allele frequencies of human leukocyte antigen‐G in a Korean population

Park

Kim

Kwon

et al. 2011

Int J Immunogenetics

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“…In addition to the described variation sites discussed above, the 3′UTR presents several other polymorphisms frequently observed in highly genetically diverse populations [82, 92], which have not been associated with differential HLA-G expression so far, as illustrated in Fig. 5.…”

Section: Nomenclature Of Hla-g Allelesmentioning

confidence: 92%

Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association

Donadi

Castelli

Arnaiz‐Villena³

et al. 2010

Cell. Mol. Life Sci.

312

405

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The HLA-G gene displays several peculiarities that are distinct from those of classical HLA class I genes. The unique structure of the HLA-G molecule permits a restricted peptide presentation and allows the modulation of the cells of the immune system. Although polymorphic sites may potentially influence all biological functions of HLA-G, those present at the promoter and 3′ untranslated regions have been particularly studied in experimental and pathological conditions. The relatively low polymorphism observed in the MHC-G coding region both in humans and apes may represent a strong selective pressure for invariance, whereas, in regulatory regions several lines of evidence support the role of balancing selection. Since HLA-G has immunomodulatory properties, the understanding of gene regulation and the role of polymorphic sites on gene function may permit an individualized approach for the future use of HLA-G for therapeutic purposes.

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“…PCR products of exons 2 and 3 from both RSA patients and controls were separately immobilized on positively charged nylon membranes by dot blotting. Various oligonucleotide probes used in this study have been previously described (Alvarez et al ., 1999; Aldrich et al ., 2001). Hybridization was performed at 42 °C with dioxigenin (DIG)‐labelled probes followed by alkaline phosphatase conjugated anti‐DIG antibody reaction.…”

Section: Methodsmentioning

confidence: 99%

Analysis of human leukocyte antigen (HLA)‐G polymorphism in normal women and in women with recurrent spontaneous abortions

Abbas

Tripathi

Naik

et al. 2004

European Journal of Immunogenetics

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Human leukocyte antigen (HLA)-G is a non-classical class I antigen. It has limited expression, but is high at the foetomaternal interface. This unique expression pattern of HLA-G suggests that it might be important for survival of the foetus during pregnancy. In the present study, 120 women with recurrent spontaneous abortions (RSA) and 120 fertile control women were genotyped for the HLA-G locus. This is the first report describing HLA-G polymorphism in normal fertile and RSA women from India. The allele HLA-G*010103 was higher in women with recurrent foetal losses. Interestingly, the HLA-G*010105 and G*010108 alleles were totally absent in normal fertile women but present in RSA women with frequencies of 1.7% and 0.4%, respectively. Allele G*010107 was absent in both the groups. The frequency of the null allele G*0105N was high (13.8%) in our population as compared to other world populations. Our data support the hypothesis that HLA-G polymorphism may contribute to recurrent foetal loss.

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HLA-G genetic polymorphism in 57 Portuguese white families studied by PCR-RFLP and PCR-SSOP

Cited by 13 publications

References 13 publications

Allele frequencies of human leukocyte antigen‐G in a Korean population

Allele frequencies of human leukocyte antigen‐G in a Korean population

Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association

Analysis of human leukocyte antigen (HLA)‐G polymorphism in normal women and in women with recurrent spontaneous abortions

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