HLA-DRB1 and -DQB1 alleles in mestizo patients with Vogt-Koyanagi-Harada’s disease in Southern California

Vogt–Koyanagi–Harada disease in Hispanic patients

“…The disease is relatively uncommon in whites and African-Americans [1,2]. It is associated with HLA-DRB1*0405 in Asian populations and with HLA-DRB1*04 subtypes in Hispanic patients [3,4]. Vogt-KoyanagiHarada disease appears to be more prevalent in Japan, where it accounts for between 6.8% and 9.2% of all uveitis referrals [5].…”

Associação do sistema de histocompatibilidade humano com doenças oftalmológicas

“…A síndrome constituí-da por nefrite tubulointersticial e uveíte crônica ocorre com maior freqüência em pacientes portadores dos alelos HLA-DQA1*0101, -DQB1*0501 e -DRB1*0102, do antígeno HLA-B14 e do haplótipo HLA-DQA1*01-DQB1*05-DRB1*01. Outras uveítes crônicas associadas a moléculas HLA de classe II são a doença de Vogt-Koyanagi-Harada (VKH) e a uveíte associada à artrite reumatóide juvenil (25) . A primeira associa-se aos alelos HLA-DRB1*0404 e -DRB1*0407 (25) e a segunda, ao antígeno HLA-B27 (26) .…”

“…Outras uveítes crônicas associadas a moléculas HLA de classe II são a doença de Vogt-Koyanagi-Harada (VKH) e a uveíte associada à artrite reumatóide juvenil (25) . A primeira associa-se aos alelos HLA-DRB1*0404 e -DRB1*0407 (25) e a segunda, ao antígeno HLA-B27 (26) . Recentemente, uma terapia de indução de tolerância utilizando o peptídeo HLA-B27PD, derivado de antígenos HLA da própria retina dos pacientes, mostrou eficácia na melhora da uveíte auto-imune (27) .…”

Early versus late immunomodulatory therapy in Vogt-Koyanagi-Harada disease

“…[5][6][7] While the disease is more prevalent in Asia, VKH accounts for between 1% to 4% of uveitis referrals within the United States. 8,9 Vogt-Koyanagi-Harada disease generally presents in four phases: 1) a prodromal phase with auditory and neurologic symptoms 2) an acute uveitic phase, which may include diffuse choroiditis, exudative retinal detachment, and intraocular inflammation 3) a chronic phase, consisting of variable depigmentation of the fundus and limbus in addition to vitiligo, poliosis, and alopecia and 4) a chronic-recurrent phase with iridocyclitis, which may be chronic, recurrent or both.…”