HLA-DRB1∗ and allergy to Parietaria: linkage and association analyses

D’Amato, Mauro; Picardi, Adele; Menna, T.; Somma, Carmela Di; Ariano, R; Pietro, Angelo di; Charron, Dominique; Maggi, Enrico; Matricardi, Paolo Maria; Plebani, Alessandro; Poto, S; Testa, Genni; Sacerdoti, G; Ruffilli, A.

doi:10.1016/s0198-8859(99)00112-3

Cited by 11 publications

(9 citation statements)

References 33 publications

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“…DQB1*0202 has been related to nasal polyposis, 33 DRB1*0301 to poor response to grass pollen specific immunotherapy, 34 and DRB1*1101 to mitesensitive bronchial asthma, 35 as well as to high levels of specific IgE against Parietaria major allergen Par o 1. 36 More interestingly, the high frequency of DRB1*0701 (DR7) phenotype among patients with spina bifida with latex or hevein responsiveness, 16 together with the protective effect that-according to our results-DRB1*0701 seems to exert against latex-fruit allergy, could further explain the lower prevalence of latex-fruit allergy in patients with latex allergy and spina bifida compared with patients without spina bifida.…”

Section: Discussionsupporting

confidence: 52%

Genetic basis of the latex-fruit syndrome: Association with HLA class II alleles in a Spanish population

Blanco¹,

Sánchez-García²,

Torres-Galván³

et al. 2004

Journal of Allergy and Clinical Immunology

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Section: Discussionsupporting

confidence: 52%

Genetic basis of the latex-fruit syndrome: Association with HLA class II alleles in a Spanish population

Blanco¹,

Sánchez-García²,

Torres-Galván³

et al. 2004

Journal of Allergy and Clinical Immunology

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“…In low IgE responder patients (low total IgE and/or monosensitized), the allergic sensitization depends more closely on HLA‐DR or DQ molecules than in patients with high total IgE or polysensitized . In another study, the Parietaria IgE antibody response was associated with DRB1*1104 in patients with low total IgE and with DRB1*1101 in patients with high total IgE . Genetic restrictions of Ole e1 are associated with total serum IgE levels .…”

Section: Mono‐ and Polysensitization Against Allergensmentioning

confidence: 92%

Are allergic multimorbidities and IgE polysensitization associated with the persistence or re‐occurrence of foetal type 2 signalling? The MeDALL hypothesis

Bousquet

Antó

Wickman

et al. 2015

Allergy

125

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Allergic diseases [asthma, rhinitis and atopic dermatitis (AD)] are complex. They are associated with allergen‐specific IgE and nonallergic mechanisms that may coexist in the same patient. In addition, these diseases tend to cluster and patients present concomitant or consecutive diseases (multimorbidity). IgE sensitization should be considered as a quantitative trait. Important clinical and immunological differences exist between mono‐ and polysensitized subjects. Multimorbidities of allergic diseases share common causal mechanisms that are only partly IgE‐mediated. Persistence of allergic diseases over time is associated with multimorbidity and/or IgE polysensitization. The importance of the family history of allergy may decrease with age. This review puts forward the hypothesis that allergic multimorbidities and IgE polysensitization are associated and related to the persistence or re‐occurrence of foetal type 2 signalling. Asthma, rhinitis and AD are manifestations of a common systemic immune imbalance (mesodermal origin) with specific patterns of remodelling (ectodermal or endodermal origin). This study proposes a new classification of IgE‐mediated allergic diseases that allows the definition of novel phenotypes to (i) better understand genetic and epigenetic mechanisms, (ii) better stratify allergic preschool children for prognosis and (iii) propose novel strategies of treatment and prevention.

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“…In low‐IgE responder patients (low total IgE or monosensitized) the allergic sensitization depends more closely on HLA‐DR or DQ molecules than in patients with high total IgE or polysensitized (32, 33). In another study, the Parietaria IgE antibody response was associated with DRB1*1104 in patients with low total IgE and with DRB1*1101 in patients with high total IgE (34). HLA‐DR4 is a protective class II antigen against sensitivity to Ole e 1, the major antigen of olive pollen, and HLA‐DQ2 is a risk factor for it (35).…”

Section: Mono and Polysensitization Against Allergensmentioning

confidence: 98%

Factors responsible for differences between asymptomatic subjects and patients presenting an IgE sensitization to allergens. A GA²LEN project

Bousquet

Antó

Bachert

et al. 2006

Allergy

122

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Factors responsible for differences between asymptomatic subjects and patients presenting an IgE sensitization to allergens. A GA 2 LEN projectThe synthesis of allergen-specific IgE is required for the development of allergic diseases including allergic rhinitis and allergic asthma (patients), but many individuals with allergen-specific IgE do not develop symptoms (asymptomatic subjects). Differences may exist between asymptomatic subjects and patients. Whether the presence of allergen-specific IgE translates into clinical allergy most likely depends on a complex interplay of multiple factors. These include a family history of atopy, the levels of total serum IgE and, allergen-specific IgE or IgG, epitope-specificity of IgE and their degree of polyclonality (mono-vs polysensitized), as yet unidentified serum factors, the balance of T regulatory cells (Treg) and Th1/Th2 cells, the polymorphisms of the high affinity receptor for IgE (FceRI) and other factors regulating the activation of FceRI-bearing cells. Asymptomatic subjects may be more often monosensitized than patients who may be more often polysensitized. There are many unanswered important questions that need to be addressed in order to better understand how IgE sensitization translates into clinical allergy. The assessment of differences between the asymptomatic and symptomatic groups of subjects represent one of the scientific programs of Global Allergy and Asthma European Network funded by the European Union and the hypotheses underlying these differences are presented in this paper.

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HLA-DRB1∗ and allergy to Parietaria: linkage and association analyses

Cited by 11 publications

References 33 publications

Genetic basis of the latex-fruit syndrome: Association with HLA class II alleles in a Spanish population

Genetic basis of the latex-fruit syndrome: Association with HLA class II alleles in a Spanish population

Are allergic multimorbidities and IgE polysensitization associated with the persistence or re‐occurrence of foetal type 2 signalling? The MeDALL hypothesis

Factors responsible for differences between asymptomatic subjects and patients presenting an IgE sensitization to allergens. A GA²LEN project

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HLA-DRB1∗ and allergy to Parietaria: linkage and association analyses

Cited by 11 publications

References 33 publications

Genetic basis of the latex-fruit syndrome: Association with HLA class II alleles in a Spanish population

Genetic basis of the latex-fruit syndrome: Association with HLA class II alleles in a Spanish population

Are allergic multimorbidities and IgE polysensitization associated with the persistence or re‐occurrence of foetal type 2 signalling? The MeDALL hypothesis

Factors responsible for differences between asymptomatic subjects and patients presenting an IgE sensitization to allergens. A GA2LEN project

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Product

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About

Factors responsible for differences between asymptomatic subjects and patients presenting an IgE sensitization to allergens. A GA²LEN project