Genetic basis of the latex-fruit syndrome: Association with HLA class II alleles in a Spanish population

Blanco, Carlos; Sánchez-García, Florentino; Torres-Galván, María José; Dumpiérrez, Antonio G.; Almeida, Lourdes; Figueroa, Javier; Ortega, Natividad; Castillo, R.; Gallego, M. Dolores; Carrillo, Teresa

doi:10.1016/j.jaci.2004.06.022

Cited by 25 publications

(12 citation statements)

References 36 publications

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“…In the early 1980s, Marsh et al [2] observed an association between an MHC-II-encoding HLA genotype and the immune response to the short ragweed pollen allergen Amb a 5 (Ra5). Since then, several HLA genotypes have been shown to be associated with respiratory and food allergies [3,4,5,6]. The correlation between an HLA genotype and sensitization to an allergen is strongest if the allergen contains a single immunodominant T cell epitope, as shown for the major mugwort pollen allergen Art v 1 [7].…”

Section: Introductionmentioning

confidence: 99%

Role of Human Leucocyte Antigen DQ in the Presentation of T Cell Epitopes in the Major Cow’s Milk Allergen αs1-Casein

Ruiter

Rozemuller²,

Dijk³

et al. 2007

Int Arch Allergy Immunol

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Background: Little is known about the association between human leucocyte antigen (HLA) and cow’s milk allergy (CMA). The aim of the present study was to determine the HLA restriction of T cell clones (TCCs) specific to αs1-casein, the most abundant milk protein, and to study possible HLA class II allele associations with CMA. Methods: αs1-Casein-specific TCCs were derived from 6 children with CMA, 9 atopic children without CMA and 5 non-atopic children. T cell epitope specificity was defined by stimulation with overlapping peptides, spanning the αs1-casein molecule. HLA restriction was determined in proliferation assays using antibodies blocking either HLA-DP, HLA-DQ or HLA-DR. HLA genotyping was performed in 32 subjects with CMA, 23 atopic and 22 non-atopic individuals. Results: Ten TCCs were restricted to HLA-DQ, 6 TCCs to HLA-DR and 4 TCCs to HLA-DP. The sequence in αs1-casein that was most immunogenic to T cells from children with CMA contained T cell epitopes restricted to DQB1*0201, DPB1*0401 and DRB1*1501. The DQB1*0501 allele frequency was lower in children with CMA than in non-atopic children, but this difference could not be confirmed in an additional group of subjects with and without CMA. Conclusions: HLA-DQ plays a substantial role in the presentation of T cell epitopes in αs1-casein. However, HLA class II allele frequencies do not show major differences between cow’s milk allergic, atopic and non-atopic subjects. T cell epitopes in the most immunogenic region are presented by various abundantly present HLA genotypes. Therefore, this sequence may be a suitable target for peptide immunotherapy.

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Section: Introductionmentioning

confidence: 99%

Role of Human Leucocyte Antigen DQ in the Presentation of T Cell Epitopes in the Major Cow’s Milk Allergen αs1-Casein

Ruiter

Rozemuller²,

Dijk³

et al. 2007

Int Arch Allergy Immunol

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“…Blanco et al 20 conducted a case-control study in a group of patients allergic to latex to investigate the association between this syndrome when associated to fruits, to class I and II HLA genes, HLA DR functional groups and to IL4-R1 and Fc R1-βca markers. They concluded that latex/fruits allergy is associated with HLA-DQB1*0201, DRB1*0301, and *0901 alleles, as well as the HLA-DE functional group E. Allergy to latex not related to fruits is associated with DQB1*0202 alleles, and both allergies are associated to DRB1*0701 and *1101 alleles.…”

Section: Resultsmentioning

confidence: 99%

Prevalência de sinais de sensibilidade ao látex em pacientes com mielomeningocele submetidos a múltiplos procedimentos cirúrgicos

Yeh¹,

Kiohara²,

Soares³

et al. 2012

Rev. Bras. Anestesiol.

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Summary: Yeh WSC, Kiohara PR, Soares ISC, Carmona MJC, Rocha FT, Galvão CES -Prevalence of Sensitivity Signals to Latex in Meningomyelocele Patients Undergoing Multiple Surgical Procedures. Background and objectives:The number of patients allergic to latex has increased significantly. It is crucial to recognize the cases in order to prevent and apply adequate treatment. The objective of this study was to evaluate the prevalence of allergy to latex in meningomyelocele patients.

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“…There is relatively little information on this, though associations have been found between specific HLA alleles and tree nut allergy [44] and latex allergy [45].…”

Section: Genesmentioning

confidence: 99%

The Epidemiology of Food Allergy

Burney

Keil

Grabenhenrich

et al. 2014

Risk Management for Food Allergy

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Genetic basis of the latex-fruit syndrome: Association with HLA class II alleles in a Spanish population

Cited by 25 publications

References 36 publications

Role of Human Leucocyte Antigen DQ in the Presentation of T Cell Epitopes in the Major Cow’s Milk Allergen αs1-Casein

Role of Human Leucocyte Antigen DQ in the Presentation of T Cell Epitopes in the Major Cow’s Milk Allergen αs1-Casein

Prevalência de sinais de sensibilidade ao látex em pacientes com mielomeningocele submetidos a múltiplos procedimentos cirúrgicos

The Epidemiology of Food Allergy

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