HLA-DRB1 Alleles and Cervical Squamous Cell Carcinoma: Experimental Study and Meta-Analysis

Yang, Yuh‐Cheng; Chang, Tzu-Yang; Lee, Yann-Jinn; Su, Tsung-Hsien; Dang, Ching-Wen; Wu, Chao-Chih; Liu, Hsin‐Fu; Chu, Chen‐Chung; Lin, Min

doi:10.1016/j.humimm.2006.03.017

Cited by 37 publications

(30 citation statements)

References 40 publications

(62 reference statements)

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“…In the present study, a highly significant association (p c ϭ 0.002) was established for the DRB1*15 allele for the cervical cases, with a 2.5-and 2.8-fold increased risk for total cases versus controls and invasive cancer versus controls, respectively. These findings are in agreement with studies on Swedish [23] and Dutch [24] cervical cancer patients and a metaanalysis study encompassing the cervical cancer-HLA DRB1 association in different world populations and Caucasian subgroups [25], as well as southwestern American Indian women with CIN [26]. Additionally, the frequency distribution for DRB1*15 (15.69%) in healthy population in the present study is comparable to that determined in a study by Ghaderi et al (2002) in a Swedish population (14.0%) [39].…”

Section: Discussionsupporting

confidence: 91%

“…Additionally, the frequency distribution for DRB1*15 (15.69%) in healthy population in the present study is comparable to that determined in a study by Ghaderi et al (2002) in a Swedish population (14.0%) [39]. The frequency distribution for DRB1*15 in healthy population is relatively higher than that of Chinese (10.2%) [25] and southwestern American Indian women (4.4%) [26], but relatively less than that of the Dutch population in the Netherlands (24.0%) [24].…”

Section: Discussionsupporting

confidence: 82%

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Association between human leukocyte antigen class II alleles and human papillomavirus-mediated cervical cancer in Indian women

et al. 2009

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 82%

Association between human leukocyte antigen class II alleles and human papillomavirus-mediated cervical cancer in Indian women

et al. 2009

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“…However, because meta-analyses use selected studies based on defined criteria, they can assess common and significant genetic factors that were not assessed in a systematic way in individual, primary studies. Similar meta-analyses of the genetic studies of pneumococcal and meningococcal infection [71], autoimmune diseases [72,73], and cancer [74] have been already reported. We found no effect of different schistosomal species on the outcome of PSHD;…”

Section: Discussionsupporting

confidence: 79%

Association of HLA and post-schistosomal hepatic disorder: A systematic review and meta-analysis

Huy

Hamada

Kikuchi

et al. 2011

Parasitology International

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Several human genetic variants, HLA antigens and alleles are reportedly linked to post-schistosomal hepatic disorder (PSHD), but the results from these reports are highly inconclusive. In order to estimate overall associations between human genetic variants, HLA antigens, HLA alleles and PSHD, we systematically reviewed and performed a meta-analysis of relevant studies in both post-schistosomal hepatic disorder and post-schistosomal non-hepatic disorder patients. PubMed, Scopus, Google Scholar, The HuGE Published Literature database, Cochrane Library, and manual search of reference lists of articles published before July 2009 were used to retrieve relevant studies. Two reviewers independently selected articles and extracted data on study characteristics and data regarding the association between genetic variants, HLA antigens, HLA alleles and PSHD in the form of 2×2 tables. A meta-analysis using fixed-effects or random-effects models to pooled odds ratios (OR) with corresponding 95% confidence intervals were calculated only if more than one study had investigated particular variation. We found 17 articles that met our eligibility criteria. Schistosoma mansoni and Schistosoma japonicum were reported as the species causing PSHD. Since human genetic variants were only investigated in one study, these markers were not assessed by meta-analysis. Thus, only HLA-genes (a total of 66 HLA markers) were conducted in the meta-analysis. Our meta-analysis showed that human leucocyte antigens HLA-DQB1*0201 (OR = 2.64, P = 0.018), DQB1*0303 (OR = 1.93, P = 0.008), and DRB1*0901 (OR = 2.14, P = 0.002) alleles and HLA-A1 (OR = 5.10, P = 0.001), A2 (OR = 2.17, P = 0.005), B5 (OR = 4.63, P = 0.001), B8 (OR = 2.99, P = 0.02), and B12 (OR = 5.49, P = 0.005) serotypes enhanced susceptibility to PSHD, whereas HLA-DQA1*0501 (OR = 0.29, P = <0.001) and DQB1*0301 (OR = 0.58, P = 0.007) 4 were protective factors against the disease. We further suggested that the DRB1*0901-DQB1*0201, DRB1*0901-DQB1*0303 and A1-B8 haplotypes enhanced susceptibility to PSHD, whereas DQA1*0501-DQB1*0301 linkage decreased the risk of PSHD. The result improved our understanding of the association between the HLA loci and PSHD with regard to pathogenic or protective T-cells and provided novel evidence that HLA alleles may influence disease severity.. 5

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“…30 In southern Chinese women, the association between HLA class II genes and cervical neoplasia varied with the type of oncogenic HPV infection. In comparison to healthy female blood donors with unknown HPV infection status, HLA DRB1*03 had a positive association with HPV18-positive HSIL and invasive cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

Associations of human leukocyte antigen class II genotypes with human papillomavirus 18 infection and cervical intraepithelial neoplasia risk

Chuang

Chen

et al. 2011

Cancer

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BACKGROUND: Only a small proportion of women infected with human papillomavirus type 18 (HPV18) may progress to persistent infection and cervical neoplasia. This community-based cohort study aimed to assess associations with human leukocyte antigen (HLA) class II genotypes for natural infection of HPV18 and subsequent risk of cervical neoplasia. METHODS: Among 10,190 cytologically normal participants, 125 with HPV18 infection were identified by HPV blot kit. HPV18 viral load at study entry was examined by real-time polymerase chain reaction; persistent infection was defined as HPV18 infection at 2 consecutive examinations. RESULTS: There was a significant association between HLA-DRB1*0403 allele and high HPV18 viral load (>1000 copies in 50 ng of total DNA) at study entry (odds ratio [OR], 7.2; 95% confidence interval [CI], 2.0-25.2). After adjustment for age and viral load at study entry, haplotype HLA-DRB1*0405-DQA1*0301-DQB1*0302 was significantly associated with persistent HPV18 infection (OR, 13.3; 95% CI, 1.7-105.9). HLA-DRB1*0403 allele was also associated with a significantly increased risk of high-grade squamous intraepithelial lesion or cancer, showing a multivariate-adjusted hazard ratio (95% CI) of 18.1 (2.6-128.5). CONCLUSIONS: HLA-DRB1*0403 allele and HLA-DRB1*0405-DQA1*0301-DQB1*0302 haplotype may play important roles in determination of high viral load and persistent infection of HPV18 and subsequent cervical neoplasia risk.

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HLA-DRB1 Alleles and Cervical Squamous Cell Carcinoma: Experimental Study and Meta-Analysis

Cited by 37 publications

References 40 publications

Association between human leukocyte antigen class II alleles and human papillomavirus-mediated cervical cancer in Indian women

Association between human leukocyte antigen class II alleles and human papillomavirus-mediated cervical cancer in Indian women

Association of HLA and post-schistosomal hepatic disorder: A systematic review and meta-analysis

Associations of human leukocyte antigen class II genotypes with human papillomavirus 18 infection and cervical intraepithelial neoplasia risk

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