HLA-DQB1 and -DRB1 alleles and cytokine polymorphisms in a Mulatto population from South East Brazil

Temin, Julia; Marques, Georgia Daniela Marcusso; Morgun, Andrey; Shulzhenko, Natalia; Rampim, Gisele F; Gerbase‐DeLima, Maria

doi:10.1016/j.humimm.2004.08.018

Cited by 6 publications

(7 citation statements)

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“…One hundred sixty‐two unrelated individuals were randomly chosen from the data bank (preserving the same ethnicity proportions of study group) and formed the control group. The allele frequencies found in the control group were similar to those reported by previous studies in samples of population from southeastern Brazil (7–9). Unlike other researchers, the authors of this study decided to not select individuals – cases or controls – from a homogeneous ethnic group, based on the premise that the Brazilian population is one of the most heterogeneous populations in the world as a result of five centuries of admixture between Europeans, Africans, and Amerindians, which produces, at the individual level, a significant dissociation of color and genomic ancestry (10).…”

supporting

confidence: 74%

HLA‐DRB104:02, DRB108:04 and DRB114* alleles associated to pemphigus vulgaris in southeastern Brazilian population

Weber¹,

Monteiro²,

Preuhs-Filho³

et al. 2011

Tissue Antigens

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supporting

confidence: 74%

HLA‐DRB104:02, DRB108:04 and DRB114* alleles associated to pemphigus vulgaris in southeastern Brazilian population

Weber¹,

Monteiro²,

Preuhs-Filho³

et al. 2011

Tissue Antigens

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“…In the southeastern population of Brazil, the prevalence of HLA-DQB1*0602 is 13.6% among Caucasians 14 and 14.30% in Mulattos. 15 Recent genome-wide association studies of HLA-DQB1*0602-positive European Caucasians, healthy Americans, and narcoleptics with cataplexy have identified the existence of a polymorphism in the T-cell receptor alpha (TRA) gene. 16,17 The TRA gene encodes a protein that activates cytotoxic CD8 cells and CD4 helper cells, resulting in susceptibility to the destruction of hypocretinergic HLA-DQB1*0602-positive cells.…”

Section: Genetics Of Narcolepsymentioning

confidence: 99%

“…7,12,13,73 However, the presence of this allele is not a sufficient or necessary factor for the development of narcolepsy. 7,73 In the general population, the prevalence of the HLA-DQB1*0602 antigen varies between 12% and 34% 8,14,15 ( Table 1). In narcolepsy without cataplexy, the HLA-DQB1*0602 prevalence rate is 40% to 60%.…”

Section: 72mentioning

confidence: 99%

Diretrizes brasileiras para o diagnóstico de narcolepsia

Alóe

Alves

Araújo

et al. 2010

Rev. Bras. Psiquiatr.

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Este artigo relata as conclusões da reunião de consenso com médicos especialistas sobre diagnóstico de narcolepsia baseada na revisão dos artigos sobre narcolepsia listados no Medline entre 1980 e 2010. A narcolepsia é uma doença crônica de início entre a primeira e segunda décadas de vida do indivíduo. Os sintomas essenciais são cataplexia e sonolência excessiva. A cataplexia é definida como episódios súbitos, recorrentes e reversíveis de fraqueza da musculatura esquelética desencadeados por situações de conteúdo emocional. Os sintomas acessórios são alucinações hipnagógicas, paralisia do sono e sono fragmentado. Critérios de diagnóstico clínico de acordo com a Classificação Internacional dos Transtornos do Sono são de sonolência excessiva e cataplexia. Recomenda-se a realização de polissonografia seguida do teste de latência múltipla do sono em um laboratório de sono para confirmação e diagnóstico de comorbidades. Quando não houver cataplexia, deve haver duas ou mais sonecas com sono REM no teste de latência múltipla do sono. Tipagem HLA-DQB1*0602 positiva com níveis de hipocretina-1 abaixo de 110pg/mL devem estar presentes para o diagnóstico de narcolepsia sem cataplexia e sem sonecas com sono REM.

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“…Studies carried out in Paraná (Braun‐Prado et al ., ; Probst et al ., ; Bicalho et al ., ; Ruiz et al ., ; Bardi et al ., ), Rio Grande do Sul (Bortolotto et al ., ), Rio de Janeiro (Moraes et al ., ), Minas Gerais (Williams et al ., ), Goiás (Trachtenberg et al ., ), Piauí (Monte et al ., ; Carvalho et al ., ), Pernambuco (Nigam et al ., ) and different regions in the state of São Paulo (Donadi et al ., 2000b; Louzada‐Junior et al ., ; Morgun et al ., ; Temin et al ., ; Salvadori et al ., ) have shown the diversity of HLA genes in regional populations.…”

Section: Introductionmentioning

confidence: 99%

Frequencies of allele groups HLA‐A, HLA‐B and HLA‐DRB1 in a population from the northwestern region of São Paulo State, Brazil

Ayo

Camargo

Xavier

et al. 2014

Int J Immunogenetics

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The aim of this study was to estimate the HLA-A, HLA-B and HLA-DRB1 allele groups frequencies in a population of 1559 volunteer bone marrow donors from the northwestern region of São Paulo State grouped according to ethnicity. An additional objective was to compare the allele frequencies of the current study with data published for other Brazilian populations. The allele groups were characterized by the PCR-rSSO method using Luminex(®) technology. Twenty HLA-A, 32 HLA-B and 13 HLA-DRB1 allele groups were identified. The most common allele groups in European descent and mixed African and European descent samples were HLA-A*02, HLA-B*35 and HLA-DRB1*13, while HLA-A*02, HLA-B*35 and HLA-DRB1*11 were more common in African descent samples. The HLA-A*23, HLA-A*36, HLA-B*58 and HLA-B*81 allele groups were more common in sample from African descent than European descent, and the HLA-DRB1*08 was more common in mixed African and European descent than in European descent. Allele group frequencies were compared with samples from other Brazilian regions. The HLA-A*30 and HLA-A*23 were more common in this study than in the populations of Rio Grande do Sul and Paraná; and the HLA-A*01, HLA-B*18, HLA-B*57 and HLA-DRB1*11 were more common in this study than in the population of Piauí. The least frequent allele groups were HLA-A*31, HLA-B*15, HLA-B*40 and HLA-DRB1*08 for the population of Piauí, HLA-A*01 and HLA-A*11 for Parana, HLA-A*02 and -A*03 for Rio Grande do Sul and HLA-DRB1*04 for Paraná, Rio Grande do Sul and Piauí. These data provide an overview on the knowledge on HLA diversity in the population of the northwestern region of São Paulo State and show that the genes of this system are useful to distinguish different ethnic groups.

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HLA-DQB1 and -DRB1 alleles and cytokine polymorphisms in a Mulatto population from South East Brazil

Cited by 6 publications

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HLA‐DRB104:02, DRB108:04 and DRB114* alleles associated to pemphigus vulgaris in southeastern Brazilian population

HLA‐DRB104:02, DRB108:04 and DRB114* alleles associated to pemphigus vulgaris in southeastern Brazilian population

Diretrizes brasileiras para o diagnóstico de narcolepsia

Frequencies of allele groups HLA‐A, HLA‐B and HLA‐DRB1 in a population from the northwestern region of São Paulo State, Brazil

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HLA-DQB1 and -DRB1 alleles and cytokine polymorphisms in a Mulatto population from South East Brazil

Cited by 6 publications

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HLA‐DRB1*04:02, DRB1*08:04 and DRB1*14 alleles associated to pemphigus vulgaris in southeastern Brazilian population

HLA‐DRB1*04:02, DRB1*08:04 and DRB1*14 alleles associated to pemphigus vulgaris in southeastern Brazilian population

Diretrizes brasileiras para o diagnóstico de narcolepsia

Frequencies of allele groups HLA‐A, HLA‐B and HLA‐DRB1 in a population from the northwestern region of São Paulo State, Brazil

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Product

Resources

About

HLA‐DRB104:02, DRB108:04 and DRB114* alleles associated to pemphigus vulgaris in southeastern Brazilian population

HLA‐DRB104:02, DRB108:04 and DRB114* alleles associated to pemphigus vulgaris in southeastern Brazilian population