Frequencies of allele groups HLA‐A, HLA‐B and HLA‐DRB1 in a population from the northwestern region of São Paulo State, Brazil

Abstract

The aim of this study was to estimate the HLA-A, HLA-B and HLA-DRB1 allele groups frequencies in a population of 1559 volunteer bone marrow donors from the northwestern region of São Paulo State grouped according to ethnicity. An additional objective was to compare the allele frequencies of the current study with data published for other Brazilian populations. The allele groups were characterized by the PCR-rSSO method using Luminex(®) technology. Twenty HLA-A, 32 HLA-B and 13 HLA-DRB1 allele groups were identified. The most common allele groups in European descent and mixed African and European descent samples were HLA-A*02, HLA-B*35 and HLA-DRB1*13, while HLA-A*02, HLA-B*35 and HLA-DRB1*11 were more common in African descent samples. The HLA-A*23, HLA-A*36, HLA-B*58 and HLA-B*81 allele groups were more common in sample from African descent than European descent, and the HLA-DRB1*08 was more common in mixed African and European descent than in European descent. Allele group frequencies were compared with samples from other Brazilian regions. The HLA-A*30 and HLA-A*23 were more common in this study than in the populations of Rio Grande do Sul and Paraná; and the HLA-A*01, HLA-B*18, HLA-B*57 and HLA-DRB1*11 were more common in this study than in the population of Piauí. The least frequent allele groups were HLA-A*31, HLA-B*15, HLA-B*40 and HLA-DRB1*08 for the population of Piauí, HLA-A*01 and HLA-A*11 for Parana, HLA-A*02 and -A*03 for Rio Grande do Sul and HLA-DRB1*04 for Paraná, Rio Grande do Sul and Piauí. These data provide an overview on the knowledge on HLA diversity in the population of the northwestern region of São Paulo State and show that the genes of this system are useful to distinguish different ethnic groups.

Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes

“…In the present study, we examined the distribution of HLA-B, HLA-C, and KIR genes in TB and/or HIVinfected patients and investigated the putative role of these genes in the occurrence of TB/HIV-IRIS. The individuals included in the present study had their HLA-B, HLA-C, and KIR genes determined, and the frequency data observed corroborated what has been described for the HIV-1-infected population [12,69] and the general Brazilian population [70][71][72][73][74][75]. HLA-B*08 and female gender were associated with protection against TB onset in the studied population.…”

High‐resolution characterization of 12 classical and non‐classical HLA loci in Southern Brazilians

“…Polymorphism of HLA-A, -B, and -DRB1 in Brazil was deeply analyzed based on serologic or low-resolution genotyping volunteer donors enrolled in REDOME (Brazilian Registry of Bone Marrow Donor). [53][54][55][56] However, few studies describe the diversity of many HLA loci at high resolution in the same population. Population studies are important for evolutionary and anthropological studies.…”

HLA diversity in Brazil

“…Ayo et al described the HLA‐A, ‐B and ‐DRB1 profile from more than 1500 volunteer bone marrow donors from the Northwest region of the state of São Paulo. Populations in Southeast Brazil have a high frequency of HLA alleles that are common in European populations, but they also show HLA alleles common in African populations . In Bauru, another city from São Paulo state, more than 3500 voluntary bone marrow donors were studied, 86% of whom declared themselves White .…”

“…These results confirm what is widely known about the admixture character of the Brazilian populations, with individuals presenting a mixture of HLA alleles and haplotypes commons of White, Black and Native American populations irrespective of its self-(or hetero) classification. 13,30 Ayo et al 31 described the HLA-A, -B and -DRB1 profile from more than 1500 volunteer bone marrow donors from the Northwest region of the state of São Paulo. Populations in Southeast Brazil have a high frequency of HLA alleles that are common in European populations, but they also show HLA alleles common in African populations.…”

“…Populations in Southeast Brazil have a high frequency of HLA alleles that are common in European populations, but they also show HLA alleles common in African populations. 31 In Bauru, another city from São Paulo state, more than 3500 voluntary bone marrow donors were studied, 86% of whom declared themselves White. Compared with other Brazilian populations, the population of Bauru has more similarities with populations from Northeast Brazil than with the populations from South Brazil, which can be explained by having experienced a similar type of colonization.…”