HLA‐DP antigen and Takayasu arteritis

Abstract

Sixty-four patients with Takayasu arteritis and 317 healthy individuals in the Japanese population were examined for HLA-A, -B and -C alleles by serological typing and for HLA-DR, DQ and DP alleles by DNA typing using PCR/SSOP analysis. The frequencies of HLA-Bw52, DRB1*1502, DRB5*0102, DQA1*0103, DQB1*0601 and DPB1*0901 alleles were significantly increased and the frequencies of HLA-Bw54, DRB1*0405, DRB4*0101, DQA1*0301, DQB1*0401 alleles were significantly decreased. Strong linkage disequilibria among the increased alleles and among the decreased alleles were evident in the Japanese population. Therefore, the combination or haplotype of HLA-Bw52-DRB1*1502-DRB5*0102-DQA1*0103-DQB1*0601 -DPA1*02-DPB1*0901 may confer susceptibility to Takayasu arteritis while another combination or haplotype of HLA-Bw54-DRB1*0405-DRB4*0101-DQA1*0301-DQB1++ +*0401 may confer resistance to the disease. Because this is the first evidence for the association between an HLA-DP allele and Takayasu arteritis, we examined the nucleotide sequences of the DPB1*0901 allele from a patient and her healthy relatives and found no difference. The disease is therefore not caused by a mutated DPB1 gene.

Beryllium presentation to CD4+T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease

“…For example, the major genetic contribution to rheumatoid arthritis involves DRB1 alleles such as *0401 and *0404 (27), whereas HLA-DQ alleles, especially DQ2 and DQ8, provide the major genetic contribution to type 1 diabetes (26). Certain DP alleles also have been implicated as genetic susceptibility alleles for pauci-articular juvenile chronic arthritis (28), Graves disease (29), and Takayasu's arteritis (30). One central hypothesis for the increased susceptibility to disease is that the associated class II molecule preferentially presents a critical epitope to disease-relevant T cells.…”

A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation

“…A number of autoimmune diseases have been associated with HLA-DP. [4][5][6][7][8] HLA-DP-restricted virus, 9 bacterial, 10 or tumor 11 antigenspecific T cells have been described. HLA-DP has also been shown to be capable of presentation of HLA-A1 or HLA-DR3-derived allopeptides for indirect allorecognition by HLA-DP-restricted alloreactive CD4 ϩ T cells.…”

New Human Leukocyte Antigen Risk Allele in Japanese Patients With Takayasu Arteritis

“…[11][12][13][14] In the Japanese population, the HLA-B52 and -B39 haplotypes are closely associated with susceptibility to TA. 15, 16 In addition, it has been suggested that the presence of specific HLA-B alleles is related to clinical manifestations of TA.…”