HLA class II variation in the Gila river Indian Community of Arizona: Alleles, haplotypes, and a high frequency epitope at the HLA-DR locus

Williams, Robert C.; McAuley, Joan E.

doi:10.1016/0198-8859(92)90049-s

Cited by 17 publications

(8 citation statements)

References 11 publications

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“…Antigen DR3/4/5 or DR3 x 6, described in Pimans, Hopi and Navajo from North-America (27,47) was not seen in these tribes. All HLA-A and HLA-C specificities, as well as B51, B62 and B39 were inconspicuous.…”

Section: Discussionmentioning

confidence: 75%

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The HLA polymorphsm of two distinctive South‐American Indian tribes: The Kaingang and the Guarani

Luiza¹,

Erler²,

Luz³

et al. 1993

Tissue Antigens

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The HLA-A, B, C, DR and DQ antigens of 240 Kaingang and 98 Guarani individuals have been characterized. The most frequent antigens found among the Kaingang are A31, 2, 24; B35, 51, 39, 48; Cw4, 7, 3, 1; DR8, 4, 2; DQ blank, 3. In the Guarani, they are A2, 28, 31; B40, 62, "53G"; Cw3, 4; DR2, 4, 8, 6; DQ3, blank. B " 53G" is an unusual antigen of the B5 cross-reactive group. DQ blank possibly corresponds to DQ4, not tested in this study. The reaction patterns of B35, B40 and DR4 indicate intra-tribal (of B35 and B40), and inter-tribal (DR4, B40 and B35) heterogeneity of these antigens. 408 Kaingang and 141 Guarani haplotypes were defined by segregation analysis. Of the commonest 10 Guarani and 9 Kaingang haplotypes, only one is shared by both tribes. Significant, positive linkage disequilibrium values for HLA-A,B; HLA-A,C; HLA-B,DR and most HLA-B,C antigen pairs were also different for the two populations. Genetic distance estimates between these two and another seven South-American Indian populations, and relative to the major human races (negroids, caucasoids, and mongoloids) reveal a comparatively high degree of divergence between the Kaingang and the Guarani, which is uncommon for Amerindian populations living close one to another.

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Section: Discussionmentioning

confidence: 75%

“…The frequencies 230 of "blank" is very low for HLA-A and HLA-B (gf 5 0.01 7), low for HLA-DR (gf = 0.035), but high for HLA-C (gf=0.135) and HLA-DQ (gf= 0.541). However, it should be noted that DQ4, common in some Amerindian Tribes (26,27), was not tested for in this study.…”

Section: Antigen and Allele Frequenciesmentioning

confidence: 98%

The HLA polymorphsm of two distinctive South‐American Indian tribes: The Kaingang and the Guarani

Luiza¹,

Erler²,

Luz³

et al. 1993

Tissue Antigens

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“…HLA-DR sample (n=613). This was a subset of the population sample that was typed for the HLA-DR locus either by serological or high-resolution DNA methods [6,7].…”

Section: Derivation Of Analytical Samples the Analytical Groups Inmentioning

confidence: 99%

“…In prospective studies, obesity, insulin resistance and the acute insulin response (AIR) predicted the disease [3,4]. More than 2,000 Pima Indians have been characterised for HLA genotypes, which has led to the definition of new alleles at the HLA-B, HLA-C and DRB1 loci and descriptions of the distribution and population genetics of HLA variation in persons of full Pima heritage [5][6][7]. Recently, 100 K [8] and 1 M [9] single-nucleotide polymorphism (SNP) genomewide association studies have been conducted in this population.…”

Section: Introductionmentioning

confidence: 99%

HLA-DRB1 reduces the risk of type 2 diabetes mellitus by increased insulin secretion

et al. 2011

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Aims/hypothesis We sought to identify the physiological implications of genetic variation at the HLA-DRB1 region in full-heritage Pima Indians in Arizona. Methods Single-nucleotide polymorphisms from the HLA region on chromosome 6p were tested for association with skeletal muscle mRNA expression of HLA-DRB1 and HLA-DRA, and with type 2 diabetes mellitus and prediabetic traits. Results The A allele at rs9268852, which tags HLA-DRB1*02 (1602), was associated both with higher HLA-DRB1 mRNA expression (n=133, p=4.27×10

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“…restricted, there being three alleles with significant frequency at the HLA-A locus, *A2, *A24, and *A30, while at HLA-B only *B5102, *B4005, *B27, *B35, *B39, *B60, and *B61 segregate in the population at polymorphic frequencies greater than 0.01 (14). HLA serology from Piman samples has played a role in a number of International HLA Workshops, and has led to the definition of new serological and DNA alleles including HLA*B4005 (BN21) (16), HLA*B5102 (17), and HLA* DR3X6(DRB1*1402/*1406) (15) the class I1 DR3X6 is associated with rheumatoid arthritis (1 8) loci. In addition it has been reported + ?…”

mentioning

confidence: 99%

HLA*A2 confers mortality risk for cardiovascular disease in Pimans

et al. 1996

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A sample of 1465 full heritage Piman Indians from Arizona were typed for the serological antigens of the HLA class I loci and then incorporated into a survival study that ended December 31, 1991. The total follow-up time was 11,749 person-years with an average of 8.0 years per person. During the study 298 persons died, 54 from cardiovascular disease (CVD). Allele HLA*A2 conferred a 4.94 fold rate for death from CVD (95% C.I. 1.91-12.77). When controlled for the potential confounding variables, cholesterol, mean blood pressure, smoking, body mass index, rheumatoid factor titer, and nephropathy, the mortality rate ratio (MRR) was 5.42 (95% C.I. 1.98-14.82). There was no statistically significant association of mortality with other HLA-A or HLA-B alleles, or for causes of death not related to cardiovascular disease.

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HLA class II variation in the Gila river Indian Community of Arizona: Alleles, haplotypes, and a high frequency epitope at the HLA-DR locus

Cited by 17 publications

References 11 publications

The HLA polymorphsm of two distinctive South‐American Indian tribes: The Kaingang and the Guarani

The HLA polymorphsm of two distinctive South‐American Indian tribes: The Kaingang and the Guarani

HLA-DRB1 reduces the risk of type 2 diabetes mellitus by increased insulin secretion

HLA*A2 confers mortality risk for cardiovascular disease in Pimans

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