HLA<i>*</i>A2 confers mortality risk for cardiovascular disease in Pimans

Williams, Robert C.; Hanson, Robert L.; Pettitt, David J.; Sievers, Maurice L.; Nelson, Robert G.; Knowler, William C.

doi:10.1111/j.1399-0039.1996.tb02539.x

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…Additionally, high frequencies of HLA A2 [10, 25], DR4 [25, 26, 27]and DQ7 [28]have been found in some populations with T2DM. HLA-A2 has also been associated with microalbuminuria in people with T1DM [29], and with mortality from cardiovascular disease in Pima Indians [30]. Finally, an increased occurrence of HLA-B62 has been reported in Blacks with T1DM and DESRD [31].…”

Section: Discussionmentioning

confidence: 99%

Increased Frequency of HLA A2/DR4 and A2/DR8 Haplotypes in Young Saskatchewan Aboriginal People with Diabetic End-Stage Renal Disease

Dyck¹,

Bohm²,

Klomp³

2003

Am J Nephrol

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Aims: To determine the association of HLA with diabetic end-stage renal disease (DESRD) in Saskatchewan aboriginal people. Methods: This was a retrospective study of HLA profiles in four groups of Saskatchewan residents with ESRD diagnosed from 1980 to 1998: aboriginal people with and without DESRD, and non-aboriginal people with and without DESRD. The aboriginal DESRD group was also subdivided into those ≤50 and >50 years of age. Frequencies of individual and combinations of HLA antigens were compared between groups and subgroups. Results: HLA data were available for 634 subjects. Young aboriginal people with DESRD had a higher frequency of HLA-A2 than older AB DESRD subjects (69 vs. 36%; p = 0.03), and of HLA-DR4 and/or DR8 compared to older AB DESRD subjects (91 vs. 68%; p = 0.07) and AB non-DESRD subjects (91 vs. 67%; p = 0.03). Over 65% of young AB DESRD subjects had either an A2/DR4 or A2/DR8 haplotype (odds ratio 5.09 [confidence intervals 1.35, 20.15] versus older AB DESRD subjects; odds ratio 3.32 [confidence intervals 1.20, 9.3] versus AB non-DESRD subjects). Forty percent of young AB DESRD subjects were homozygous for at least one of A2, DR4 or DR8. Conclusions: Our findings suggest that DESRD in young AB subjects with T2DM has a genetic basis related to HLA.

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Section: Discussionmentioning

confidence: 99%

Increased Frequency of HLA A2/DR4 and A2/DR8 Haplotypes in Young Saskatchewan Aboriginal People with Diabetic End-Stage Renal Disease

Dyck¹,

Bohm²,

Klomp³

2003

Am J Nephrol

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“…The human leukocyte antigen (HLA) loci have played an important role in the many epidemiological studies that have been performed. It has been reported that HLA‐A*02 is associated with Type 2 diabetes, an allele that also confers a mortality risk for cardiovascular disease (3, 4) . A meta‐analysis revealed an association between the most common class II allele, HLA‐DRB1*1402, and rheumatoid arthritis (5).…”

Section: Introductionmentioning

confidence: 99%

Molecular variation at the HLA‐A, B, C, DRB1, DQA1, and DQB1 loci in full heritage American Indians in Arizona: private haplotypes and their evolution

Williams

Chen

Endres³

et al. 2009

Tissue Antigens

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A sample of 492 full heritage, unrelated residents of the Gila River Indian Community (GRIC) of Arizona were characterized for their high resolution DNA alleles at the HLA-A, B, C, DRB1, DQA1, and DQB1 loci. Only 5 allelic categories are found at HLA-A, 10 at HLA-B, 8 at HLA-C and HLA-DR, and 4 at DQA1 and DQB1. There is little evidence for population structure at the 6 loci. Two "private" alleles, B*5102 and B*4005, that are found nearly exclusively in American Indian populations in the desert southwest and northern Mexico, are likely new mutations after the first inhabitation of the area, the evolution of which are reflected in the contemporary distribution of their respective haplotypes. DRB1*1402 has the highest reported frequency of any specificity at the DRB1 locus, 0.7461, and serves as a sensitive probe for locating related east Asian populations. The haplotypes in this population also exhibit a highly restricted distribution and strong genetic disequilibria, which has important implications for matching solid organ and bone marrow allografts. It is shown that, when one considers HLA-A-B-DRB1 homozygotes as allograft donors for all full heritage members of the GRIC, 50% of the community would find a non-mismatched organ within the homozygotes for the 6 most common haplotypes. This raises questions about transplantation policy and whether, in the presence of high frequency private alleles and a restricted number of haplotypes, the full heritage American Indian community of the desert southwest should act as its own pool of donors for its affected members.

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“…When controlled for potential confounding variables, cholesterol, average blood pressure, smoking, body mass index, rheumatoid factor titter, and nephropathy, the mortality ratio (MRR) was 5.42 (95% C. 1.98-14.82) There was no relationship between mortality that was statistically significant with HLA-A or other HLA-B alleles, or for causes of death not related to cardiovascular disease. (Williams et al 1996) (Howard et al 1986;Klemp et al 1988;Rudwaleit et al 1995;Ayed et al 2004;Cortes et al 2004) (Collins et al 2017). Those number of TB patients contrast with the research of HLA correlation with TB in Indonesia.…”

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confidence: 86%

Indonesians Human Leukocyte Antigen (HLA) Distributions and Correlations with Global Diseases

Pradana

Widjaya

Wahjudi

2019

Immunological Investigations

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In Human, Major Histocompatibility Complex known as Human Leukocyte Antigen (HLA). The HLA grouped into three subclasses regions: the class I region, the class II region, and the class III region. There are thousands of polymorphic HLAs, many of them are proven to have correlations with diseases. Indonesia consists of diverse ethnicity people and populations. It carries a unique genetic diversity between one and another geographical positions. This paper aims to extract Indonesians HLA allele data, mapping the data, and correlating them with global diseases. From the study, it is found that global diseases, like Crohn's disease, rheumatoid arthritis, Graves' disease, gelatin allergy, T1D, HIV, systemic lupus erythematosus, juvenile chronic arthritis, and Mycobacterial disease (tuberculosis and leprosy) suspected associated with the Indonesian HLA profiles.

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HLA*A2 confers mortality risk for cardiovascular disease in Pimans

Cited by 6 publications

References 29 publications

Increased Frequency of HLA A2/DR4 and A2/DR8 Haplotypes in Young Saskatchewan Aboriginal People with Diabetic End-Stage Renal Disease

Increased Frequency of HLA A2/DR4 and A2/DR8 Haplotypes in Young Saskatchewan Aboriginal People with Diabetic End-Stage Renal Disease

Molecular variation at the HLA‐A, B, C, DRB1, DQA1, and DQB1 loci in full heritage American Indians in Arizona: private haplotypes and their evolution

Indonesians Human Leukocyte Antigen (HLA) Distributions and Correlations with Global Diseases

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