HLA class II polymorphism in Saudi patients with multiple sclerosis

Jumah, Mohammed Al; Kojan, Suleiman; Shehri, Abdulrahman M. Al; Balwi, Mohammed Al; Abdulkarim, Ibrahim Al; Masuadi, Emad; Alhaidan, Yazeid; AlAbdulrahman, Abdulkareem; Hajeer, Ali H.

doi:10.1111/tan.13173

Cited by 12 publications

(10 citation statements)

References 47 publications

(86 reference statements)

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“…It was widely believed that MS may be the result of the interaction between genetic and environmental factors together [17]. Similar results were also reported between HLA alleles variant and MS [19].…”

Section: Discussionsupporting

confidence: 76%

Meta-analysis of FOXP3 gene rs3761548 and rs2232365 polymorphism and multiple sclerosis susceptibility

Zhang

Líu

et al. 2019

Preprint

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Background: Multiple sclerosis (MS) is a common autoimmune disease of the central nervous system (CNS), and is associated with genetic factors. FOXP3 gene polymorphism has been reported as the risk factor for MS, however, previous studies have showed conflicting results. The purpose of this study is to investigate the impact of FOXP3 gene polymorphism on the MS susceptibility through a meta-analysis. Methods: Pubmed, Embase, library of Cochrane, and Web of Science were used to search the eligible articles up to 1 Oct 2018. The odds ratio (ORs) and its 95 % confidence intervals (CI) were used to evaluate the strength of association. Allele model, homozygote model, heterozygote model, dominant model, and recessive model were used to evaluate the association between FOXP3 gene polymorphism and MS. Results: A total of 5 studies contained 1276 MS patients and 1447 controls (for rs3761548) and 600 MS patients and 640 controls (for rs2232365) were enrolled in this meta-analysis. The association showed significant differences in allele and dominant model for rs3761548 polymorphism. In addition, a clear tendency to significance was detected in homozygote and recessive model for rs3761548 (p = 0.052). Subgroup analysis indicated a significant risk of MS in all genotype models but heterozygotes in Asians. Conclusion: FOXP3 gene polymorphism rs3761548 was associated with a higher MS risk, especially in Asians. This conclusion needs to be validated in more large samples and multiracial studies. Keywords: FOXP3 gene, single nucleotide polymorphism, multiple sclerosis, meta-analysis.

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Section: Discussionsupporting

confidence: 76%

Meta-analysis of FOXP3 gene rs3761548 and rs2232365 polymorphism and multiple sclerosis susceptibility

Zhang

Líu

et al. 2019

Preprint

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“…In Saudi Arabia, HLA-DRB1*15:01 is the most frequently observed risk allele for MS among Saudi patients. 10 This is in line with MS risk alleles observed in patients from Iran. [11][12][13][14] Likewise, it is the same allele reported among patients with MS from Sweden, Australia, the Netherlands, Spain, and Italy.…”

Section: Introductionsupporting

confidence: 84%

Association of infections with multiple sclerosis in Gulf Cooperation Council countries: a review

Wutayd

2019

J Int Med Res

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Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system, causing inflammation, demyelination, and neurodegeneration. Infection can play a role in its etiology. Herein, a review is presented of studies that have reported an association between infection and MS risk in countries of the Arabian Gulf region. Searches of the PubMed, Google Scholar, and Science Direct databases were carried out using various search terms, and relevant studies published through January 2019 on the epidemiology of MS in Gulf Cooperation Council countries identified. MS has been found to be associated with measles in Saudi Arabia and Epstein–Barr virus in Kuwait whereas no association has been identified between risk of MS and varicella-zoster virus, mumps, or human herpesvirus-6. However, few epidemiological studies on this topic have been conducted in countries of the Gulf region. Longitudinal and serological studies to establish robust evidence between infection and risk of MS are highly recommended, and a regional MS registry is needed.

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“…[22] Lots of potential genetic polymorphisms have also been identified and proved to be associated with the development of MS. A prior case-control study investigated the distribution of the Vitamin D receptor (VDR) gene in MS and revealed five VDR genetic polymorphisms as the risk factors for MS susceptibility. [23] Similar results were also reported between HLA alleles variant and MS. [24]…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of FOXP3 gene rs3761548 and rs2232365 polymorphism and multiple sclerosis susceptibility

Zhang

Liu

et al. 2019

Medicine

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BackgroundMultiple sclerosis (MS) is a common autoimmune disease of the central nervous system (CNS), and is associated with genetic factors. FOXP3 gene polymorphism has been reported as the risk factor for MS, however, previous studies have showed conflicting results. The purpose of this study is to investigate the association between FOXP3 gene polymorphism and the susceptibility to MS.MethodsPubmed, Embase, library of Cochrane, and Web of Science were used to search the eligible articles from January 1980 up to October 2018. The odds ratio (ORs) and its 95% confidence intervals (CI) were used to evaluate the strength of association. Allele model, homozygote model, heterozygote model, dominant model, and recessive model were used to evaluate the association between FOXP3 gene polymorphism and MS.ResultsA total of 5 studies contained 1276 MS patients and 1447 controls (for rs3761548) and 600 MS patients and 640 controls (for rs2232365) were enrolled in this meta-analysis. The association showed significant differences in allele and dominant model for rs3761548 polymorphism. In addition, a clear tendency to significance was detected in homozygote and recessive model for rs3761548 (P = .052). Subgroup analysis indicated a significant risk of MS in all genotype models but heterozygotes in Asians.ConclusionFOXP3 gene polymorphism rs3761548 was associated with a higher MS risk, especially in Asians. This conclusion needs to be validated in more large samples and multiracial studies.Level of evidenceLevel III diagnostic study.

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HLA class II polymorphism in Saudi patients with multiple sclerosis

Cited by 12 publications

References 47 publications

Meta-analysis of FOXP3 gene rs3761548 and rs2232365 polymorphism and multiple sclerosis susceptibility

Meta-analysis of FOXP3 gene rs3761548 and rs2232365 polymorphism and multiple sclerosis susceptibility

Association of infections with multiple sclerosis in Gulf Cooperation Council countries: a review

Meta-analysis of FOXP3 gene rs3761548 and rs2232365 polymorphism and multiple sclerosis susceptibility

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