Meta-analysis of FOXP3 gene rs3761548 and rs2232365 polymorphism and multiple sclerosis susceptibility

Abstract

Background: Multiple sclerosis (MS) is a common autoimmune disease of the central nervous system (CNS), and is associated with genetic factors. FOXP3 gene polymorphism has been reported as the risk factor for MS, however, previous studies have showed conflicting results. The purpose of this study is to investigate the impact of FOXP3 gene polymorphism on the MS susceptibility through a meta-analysis. Methods: Pubmed, Embase, library of Cochrane, and Web of Science were used to search the eligible articles up to 1 Oct 2018. The odds ratio (ORs) and its 95 % confidence intervals (CI) were used to evaluate the strength of association. Allele model, homozygote model, heterozygote model, dominant model, and recessive model were used to evaluate the association between FOXP3 gene polymorphism and MS. Results: A total of 5 studies contained 1276 MS patients and 1447 controls (for rs3761548) and 600 MS patients and 640 controls (for rs2232365) were enrolled in this meta-analysis. The association showed significant differences in allele and dominant model for rs3761548 polymorphism. In addition, a clear tendency to significance was detected in homozygote and recessive model for rs3761548 (p = 0.052). Subgroup analysis indicated a significant risk of MS in all genotype models but heterozygotes in Asians. Conclusion: FOXP3 gene polymorphism rs3761548 was associated with a higher MS risk, especially in Asians. This conclusion needs to be validated in more large samples and multiracial studies. Keywords: FOXP3 gene, single nucleotide polymorphism, multiple sclerosis, meta-analysis.

LncRNA‐miRNA network analysis across the Th17 cell line reveals biomarker potency of lncRNA NEAT1 and KCNQ1OT1 in multiple sclerosis

“…Our study also shows that there is a significant association between reduced FOXP3 gene expression and a positive family history of autoimmune disease ( p = 0.03). In 2016, a study of different variants of FOXP3 found a significant difference in the distribution of the rs3761548 and rs2232365 alleles in MS patients compared to controls, suggesting that this polymorphism leads to suppression of FOXP3 30 . The study found that 24% of MS patients who had recently been exposed to a viral disease such as COVID‐19 or influenza had a greater decrease in FOXP3 expression, which may be due to a significant reduction in the number of Treg cells following chronic neuroinflammation in the setting of viral infection 31 .…”

Molecular Study of IL-7R Gene Polymorphism and their Associations with Male Multiple Sclerosis Patients in Erbil Province.

“…Amongst the association study is a viable approach toward recognizing the risk genetic loci of genes as a marker such as SNP. Among these was reported the relationship of many IL-7 receptor SNPs with MS in various ethnic groups (Sahami-Fard et al, 2020, Zhang et al, 2019. The position of IL7R is chromosome 5 short arm 13 (5p13).…”

Novel association between FOXO3 rs2232365 polymorphism and late-onset preeclampsia: a case-control candidate genetic study

“…Immunological incompatibility between mother and fetus is frequently observed in preeclampsia and genetic factors related to the immunological pathway in preeclampsia have been discovered [12]. In Asian, rs3761548 polymorphism was significantly associated with multiple sclerosis, an immune-related central nervous disease [13]. In the Chinese Han population, rs2232365 and rs3761548 polymorphisms confer an important susceptibility to unexplained recurrent spontaneous abortion by altering Foxp3 function and/ or its expression [14].…”