HLA Class II Molecules and Asthma Induced by Toluene Diisocyanate

Fabbri, Leonardo M.; Mapp, C. E.; Balboni, A; Baricordi, Roberto

doi:10.1159/000237053

Cited by 7 publications

(7 citation statements)

References 1 publication

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“…Pro: Genetic differences in human leucocyte antigen (HLA) class II alleles have been associated with isocyanate asthma in several different studies. Analogous findings have been reported in common environmental asthma, and together with the known role of HLA class II in antigen presentation to CD4 T cells, support a role for prototypical Th2-driven/IgE responses [46][47][48][49][50].…”

Section: Pro/con Debatesupporting

confidence: 78%

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Pro/Con debate: is occupational asthma induced by isocyanates an immunoglobulin E‐mediated disease?

Wisnewski

Jones

2010

Clin Experimental Allergy

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Isocyanates, low-molecular weight chemicals essential to polyurethane production, are one of the most common causes of occupational asthma, yet the mechanisms by which exposure leads to disease remain unclear. While isocyanate asthma closely mirrors other Type I Immune Hypersensitivity (“Allergic”) disorders, one important characteristic of hypersensitivity (“allergen”-specific IgE) is reportedly absent in a large portion of affected individuals. This variation from common environmental asthma (which typically is induced by high molecular weight allergens) is important for two reasons. (1) Allergen-specific IgE is an important mediator of many of the symptoms of bronchial hyper-reactivity in “allergic asthma”. Lack of allergen-specific IgE in isocyanate hypersensitive individuals suggests differences in pathogenic mechanisms, with potentially unique targets for prevention and therapy. (2) Allergen-specific IgE forms the basis of the most commonly used diagnostic tests for hypersensitivity (skin prick and RAST). Without allergen-specific IgE, isocyanates may go unrecognized as the cause of asthma. In hypersensitive individuals, chronic exposure can lead to bronchial hyperreactivity that persists years after exposure ceases. Thus, the question, of whether or not isocyanate asthma is an IgE mediated disease, has important implications for disease screening/surveillance, diagnosis, treatment and prevention. The present Pro/Con Debate, addresses contemporary, controversial issues regarding IgE in isocyanate asthma.

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Section: Pro/con Debatesupporting

confidence: 78%

“…Similar findings have been reported in common environmental asthma, and together with the known role of HLA-class II in antigen presentation to CD4 T-cells, support a role for prototypical TH2-driven/IgE responses. 42–46 …”

Section: Pro/con Debatementioning

confidence: 99%

Pro/Con debate: is occupational asthma induced by isocyanates an immunoglobulin E‐mediated disease?

Wisnewski

Jones

2010

Clin Experimental Allergy

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“…The patient had a history of polypharmacologic intolerance with pruritus caused by cyclooxygenase-1 inhibitors, cutaneous rush from an unspecified local anesthetic, and an episode of severe intraoperative anaphylaxis in 1983. Because her medical records were unavailable, allergy testing was performed as per the guideline protocol 5,6 for latex, mepivacaine, marcaine, lidocaine, suxamethonium, atracurium, cisatracurium, pancuronium, vecuronium, rocuronium, thiopentale, propofol, atropine, morphine, fentanyl, remifentanyl, chlorhexidine, polyvynilpyrrolidone, polygeline, major and minor antigenic determinants of penicillin, ampicillin, and piperacillin. All the results were negative.…”

Section: Mast Cell Diseases and The Severity And Course Of Intraoperamentioning

confidence: 99%

“…Her medical record stated that she was administered fentanyl, remifentanyl, propofol, rocuronium, ampicillin, and ketorolac. Allergy testing, following the guidelines, 5 was performed for latex, atracurium, cisatracurium, pancuronium, vecuronium, rocuronium, suxamethonium thiopentale, propofol, atropine, fentanyl, remifentanyl, chlorhexidine, polyvynilpyrrolidone, and polygeline. All results were negative.…”

Section: Mast Cell Diseases and The Severity And Course Of Intraoperamentioning

confidence: 99%

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HLA CLASS II ALLELE AND IgG SENSITIZATION TO METHYLENE DIISOCYANATE IN EXPOSED WORKERS

Hur

Lee

et al. 2009

Annals of Allergy, Asthma & Immunology

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Genetic variation at the HLA and TCR loci and the development of allergy and asthma

Mansur

2002

The Hereditary Basis of Allergic Diseases

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HLA Class II Molecules and Asthma Induced by Toluene Diisocyanate

Cited by 7 publications

References 1 publication

Pro/Con debate: is occupational asthma induced by isocyanates an immunoglobulin E‐mediated disease?

Pro/Con debate: is occupational asthma induced by isocyanates an immunoglobulin E‐mediated disease?

HLA CLASS II ALLELE AND IgG SENSITIZATION TO METHYLENE DIISOCYANATE IN EXPOSED WORKERS

Genetic variation at the HLA and TCR loci and the development of allergy and asthma

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