HLA class II alleles in Chinese patients with hepatocellular carcinoma

Abstract

Although none of these associations was significant after correction for multiple testing, this report suggests that further investigations are warranted.

HLA-Class II Alleles in Egyptian Patients with Hepatocellular Carcinoma

“…In contrast to our findings, Donaldson et al (2001) found that HLA-DRB1*04 was markedly more in healthy Chinese controls than in patients Immunol Invest Downloaded from informahealthcare.com by Case Western Reserve University on 11/04/14…”

“…This variability in outcome following exposure, and the clustering of HCC within families, raise the possibility that genetic factors are also involved in susceptibility to HCC. A number of studies have sought associations with human leukocyte antigens (HLAs) and HCC (Donaldson et al, 2001). Difference in the immunologic backgrounds of infected patients might in part account for the observed variation in the individual course of disease.…”

Variation of the Killer Cell Immunoglobulin-Like Receptors andHLA-CGenes in Nasopharyngeal Carcinoma

“…The innate immune response the adaptive response, facilitates early cytokine production, and directs nonspecific cytotoxicity against invading virus (1). Previous studies have convincingly shown the association of HLA alleles involved in adaptive immunity with NPC (2-6), and these findings are consistent with studies showing HLA associations with other virally induced cancers, such as cervical and liver cancers (7)(8)(9)(10)(11)(12). However, no studies to date have examined NPC risk in the context of innate immunity, and little is known about the association between NPC and HLA-Cw alleles, HLA class I molecules involved in both the adaptive and innate immune responses.…”

Relationship between HLA-DRB1 Allele Polymorphisms and Familial Aggregations of Hepatocellular Carcinoma

“…They concluded that the DRB1*04 and DQB1*02 alleles might be risk factors for the occurrence of hcc (or: 4.373 and 3.807 respectively) and that DQB1*06 might be a protective allele (or: 0.259). Even earlier, Donaldson et al 11 had also investigated hla class ii as a risk factor for the development of hcc in Hong Kong Chinese. Their study reported that the alleles DRB1*1501 (36% of hcc patients vs. 19% of controls; or: 2.44), DQA1*0102 (42% vs. 26%; or: 2.07), and DPB1*0501 (80% vs. 63%; or: 2.35) were significantly more common in patients with hcc, and that the alleles DQA1*03 (36% vs. 56%; or: 0.53), DQB1*0302 (4.% vs. 13%; or: 0.25), and DPB1*0201 (14% vs. 29%; or: 0.4) were found at significantly lower frequencies.…”

“…To date, many genetic factors have been reported to be related to a susceptibility to hcc: polymorphisms of tumour necrosis factor α 6,7 , of epidermal growth factor and epidermal growth factor receptor 8,9 , of the transforming growth factor β1 gene 10 , and of major histocompatibility complex (mhc) or human leucocyte antigen (hla) [11][12][13][14][15] , among others. Of the foregoing genetic factors, mhc plays a key role in antivirus activity and tumour defense.…”