HLA class I Polymorphism in Mongolian and Hui Ethnic Groups from Northern China

HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations

“…For example, the predominant A-C-B haplotype, A*02:07-C*01:02-B*46:01, was predominant in Vietnamese as well as in some southern Chinese populations, such as the Dai, Hani, Miao, Bouyei, Shui, Han in Yunnan, and Han in Guangdong, but existed at low frequencies in Chinese Hui, Japanese, and Koreans. Another predominant haplotype, A*11:01-C*08:01-B*15:02, was also predominant in Vietnamese and some Chinese populations, such as the Bulang, Dai, Hani, Shui, Han in Yunnan, and Han in Guangdong, who were located in southern China (Tokunaga et al, 1997;Middleton et al, 2004;Chen et al, 2007;Hong et al, 2007;Ogata et al, 2007;Trachtenberg et al, 2007;Hoa et al, 2008;Shi et al, 2008;2010a;2010b;Wen et al, 2008;Yao et al, 2009). Based on the HLA alleles, haplotypes, and neighbor-joining tree analysis, we concluded that the Zhuang is a typical southern Chinese population.…”

“…Nei's standard genetic distances among 18 populations were calculated based on HLA-A, HLA-B, and HLA-DRB1 allele frequencies and a neighbor-joining tree was constructed using Mega4.0 software (Tamura et al, 2007). Frequency data for other Asian populations were obtained from previous studies, as follows: Wa and Jinuo (Shi et al, 2008), Bouyei (Imanishi et al, 1992;Chen et al, 2007), Maonan (Ogata et al, 2007), Han in Taiwan (Wen et al, 2008), Han in Hongkong (Hardy et al, 1997), Han in Guangdong (Trachtenberg et al, 2007), Menba (Zhang et al, 2005), Tibetan (Lai et al, 1999;, Hui (Yu et al, 2002;Hong et al, 2007), Han in Beijing (Sun et al, 1997;Deng et al, 2005), Han in Northern (Yang et al, 2006), Dai (Shi et al, 2010a), Han in Yunnan (Yao et al, 2009), and Bulang and Hani (Shi et al, 2010b). Fig.…”

HLA polymorphism in six Malay subethnic groups in Malaysia

“…With the exception of Kelantan Malays, A*24-Cw*04-B*35 was frequently observed among the TMP and other SPG and is also reported in Ashkenazi Jews (3.4%), French Corsicans (2.4%), and Native Americans (1.6%; http://www.allelefrequency.net), but is absent in Mongolian and Hui ethnic groups [29].…”

“…AMOVA was performed to estimate the total genetic structure among the BBJ, Kelantan, Minangkabau, and Rawa Malays based on the variance of gene frequencies. The HLA data were also compared with that of several populations obtained from http://www.allelefrequencies.net (accessed February 8, 2008) and from previously published papers [25][26][27][28][29][30][31][32][33].…”

“…The most frequent HLA-A serotypes (A*02, A*24, A*11, and A*33) reported in the TMP and SPG are also a set of relatively common alleles throughout SEA populations, including two Thai populations (present-day Thais: A*02, 16.3%; A*24, 18.1%; A*11, 28.9%; and A*33, 14.6%; and the Dai Lue: A*02, 22.3%; A*24, 10.4%; A*11, 37.6%; and A*33, 9.9%) [26] and Mongolians (population residing in the northern part of China (A*02, 20.2%; A*24, 20.1%; A*11, 17.2%; and A*33, 9.3%) [29]. Cw*04, Cw*07, and Cw*08, which were observed with a frequency greater than 9% in the TMP and SPG, exhibit some similarities with the distribution of these alleles in the Lisu and Nu people inhabiting Yunnan; the Lisu possess 33, 15, and 8% similarity and the Nu display 32, 10, and 16% similarity, respectively [27].…”