HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations

Shi, Li; Huang, Xiaoqin; Shi, Lei; Tao, Yu; Yao, Yufeng; Yu, Liang; Lin, Keqin; Wen, Yiping; Sun, Hao; Tokunaga, Katsushi; Chu, Jiayou

doi:10.1631/jzus.b1000285

Cited by 10 publications

(16 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A clear difference in HLA allele distribution between the northern and southern ethnic groups in China was found previously for the Hui , Tibetans , Menbas and Mongolians from the north and the Bulang , Hani , Buyi , Dai , Jinuo , Wa , Maonan , Miao and Zhuang from the south. The HLA‐A alleles, A*02:03, A*02:07 and A*11:01, were more common in the southern groups than in the northern groups (0.09 vs 0.02, 0.11 vs 0.04 and 0.34 vs 0.16, respectively, P < 0.05).…”

Section: Resultssupporting

confidence: 69%

“…For example, HLA‐A*01:01 was common in the northern ethnic groups, but absent in all the southern groups except the Buyi. Similarly, HLA‐B*15:02 was common in the southern groups (0.13), but was either absent or rare in the northern groups ( P < 0.03) .…”

Section: Resultsmentioning

confidence: 95%

“…PCA was also performed based on HLA‐A, HLA‐B, HLA‐C and HLA‐DRB1 allele frequencies using spss v16.0 software. Frequency data for other Asian populations were obtained from previous studies: Bulang and Hani , Buyi , Dai , Han in Beijing , Han in Yunnan , Han in Guangdong , Han in Taiwan , Hui , Jinuo and Wa , Maonan , Miao , Tibetan , Zhuang , Japanese , Vietnamese , Thai and Korean . Figure presents the geographic distribution of these 23 Asian populations.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Distinct HLA allele and haplotype distributions in four ethnic groups of China

et al. 2012

View full text Add to dashboard Cite

Distinct human leukocyte antigen (HLA) allele and haplotype distributions occur in the northern and southern Han populations of China. However, different ethnic groups in China show limited regional distributions for many HLA alleles and haplotypes. Therefore, it is necessary and meaningful to study the differences in HLA allele and haplotype distribution for northern and southern ethnic groups of China. A total of 428 unrelated individuals from the Lisu, Nu, Tu and Yugur ethnic populations were genotyped for HLA-A, -B, -C and -DRB1 alleles using the PCR-Luminex typing method. The frequencies of HLA alleles and statistically inferred haplotypes were calculated. A total of 29 HLA-A, 54 HLA-B, 27 HLA-C and 41 HLA-DRB1 alleles were spread throughout these four populations with distinct allele and deduced haplotype frequencies between populations. Some alleles and deduced haplotypes exhibited significantly different distributions between northern (Tu and Yugur) and southern groups (Lisu and Nu). A phylogenetic tree and principal component analysis were used to compare the HLA polymorphism between our dataset and 19 other eastern and southeastern Asian populations. This analysis showed that Lisu and Nu belong to a cluster of southern ethnic groups, while Tu and Yugur are most closely related to other northern groups. Thus, distinct ethnic population histories were revealed by analyzing HLA allelic polymorphisms with the HLA profiles of the Lisu and Nu southern Chinese ethnic groups clearly different from the Tu and Yugur northern ethnic groups. The results will be useful for future association studies of infectious disease and contribute toward a more efficient search of organ/tissue matches for transplantation.

show abstract

Section: Resultssupporting

confidence: 69%

Section: Resultsmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Distinct HLA allele and haplotype distributions in four ethnic groups of China

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The allele frequency of HLA‐B * 15 : 02 ranged from 4.25% to 15.36% in the 9 ethnic populations evaluated. The allele frequencies database indicated that the B * 15 : 02 frequency in the north Han and south Han populations was 1.9% and 7.1%, respectively, which was similar to the allele frequencies of HLA‐B * 15 : 02 previously reported in the Dai, Yi, Miao, Lisu, Hani, and Zhuang populations. Another study regarding the Lisu minority demonstrated that the B * 15 : 02 frequencies were different from those found in this study (5.77%/156 vs 12.3%/111; P < .05).…”

Section: Discussionsupporting

confidence: 85%

A study of HLA‐B15:02* in 9 different Chinese ethnics: Implications for carbamazepine related SJS/TEN

Wang

et al. 2017

HLA

View full text Add to dashboard Cite

The HLA-B*15:02 allele frequencies indicated that the prevalence of B*15:02 was different among the different ethnic populations. Because the number of carriers of B*15:02 was high in some ethnic populations, larger studies are required to confirm these findings. The Zhuang population had the highest frequency of B*15:02 in this study. More attention should be paid to CBZ-induced SJS/TEN in Chinese minority populations.

show abstract

“…In China, the Chinese‐speaking Han nationality accounts for approximately 94% of total population, and the Zhang population is the second largest ethnic group in China with a population of approximately 16.2 million. Most of the Zhuang individuals live in the Guangxi Zhuang Autonomous Region in southern China (Shi et al., ). Another important ethnic minority is the Dong population mainly living in south China, with approximately 298,700 members in Guangxi.…”

Section: Introductionmentioning

confidence: 99%

Genotype frequencies of human neutrophil antigen‐3 in the Chinese Zhuang and Dong populations

Liao

Jiao

et al. 2017

Int J Immunogenetics

View full text Add to dashboard Cite

Individuals with the human neutrophil antigen (HNA)-3b/3b type can produce HNA-3a antibodies, which have been reported to cause severe, sometimes fatal transfusion-related acute lung injury (TRALI). Our study aimed to determine the genotype frequency of HNA-3a/3b which will be helpful to estimate the potential risk for forming anti-HNA-3a, the clinically relevant antibody linked to TRALI in two different ethnic groups of southern China. Five hundred unrelated and healthy blood donors (284 male, 216 female; 300 Zhuangs, 200 Dongs) from the Guangxi Zhuang Autonomous Region were simultaneously typed for the HNA-3 allele using a polymerase chain reaction sequence-based typing (PCR-SBT) method. Genotype frequencies of HNA-3a/3a, HNA-3a/3b and HNA-3b/3b were 51.7%, 39.7% and 8.6% in the Zhuang population, and 44.0%, 49.0% and 7.0% in the Dong population, respectively. Homozygous HNA-3b/3b genotype frequency among the Zhuang population (8.6%) was significantly higher than previously reported in African Americans (0.4%), Brazilians (3.6%) and English Caucasians (2.9%) (p < .05). And the HNA-3b/3b genotype frequency among the Dong population was higher than African Americans (0.4%) (p < .05). This study showed Chinese Zhuang and Dong populations possessed a higher frequency of HNA-3b/3b genotype, suggesting that they may be at greater risk for developing anti-HNA-3a alloantibodies that may cause severe cases of TRALI. A molecular-based identification of the HNA-3b/3b genotype in all multiparous female blood donors was suggested to reduce the risk of TRALI following plasma and whole blood allogeneic transfusions.

show abstract

HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations

Cited by 10 publications

References 35 publications

Distinct HLA allele and haplotype distributions in four ethnic groups of China

Distinct HLA allele and haplotype distributions in four ethnic groups of China

A study of HLA‐B15:02* in 9 different Chinese ethnics: Implications for carbamazepine related SJS/TEN

Genotype frequencies of human neutrophil antigen‐3 in the Chinese Zhuang and Dong populations

Contact Info

Product

Resources

About

HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations

Cited by 10 publications

References 35 publications

Distinct HLA allele and haplotype distributions in four ethnic groups of China

Distinct HLA allele and haplotype distributions in four ethnic groups of China

A study of HLA‐B*15:02 in 9 different Chinese ethnics: Implications for carbamazepine related SJS/TEN

Genotype frequencies of human neutrophil antigen‐3 in the Chinese Zhuang and Dong populations

Contact Info

Product

Resources

About

A study of HLA‐B15:02* in 9 different Chinese ethnics: Implications for carbamazepine related SJS/TEN