HLA class I allele distribution of a Hong Kong Chinese population based on high‐resolution PCR‐SSOP typing

Abstract

A stem cell registry population from Hong Kong, of Chinese ethnicity, was examined for HLA-A and HLA-B alleles using a two-stage sequence-specific oligonucleotide probe system. Comparison of the HLA-A and HLA-B frequencies with different populations showed a close relationship with a Chinese population from Singapore, although there were several differences in the presence/absence of alleles at the HLA-B locus. Having the data available on these registry donors will influence the search strategy and the ongoing compilation of new donors to the registry. In addition, knowing which alleles do/do not occur in this population will aid in the distinction of ambiguities which result from the use of many of the typing kits available.

HLA polymorphism of the Zhuang population reflects the common HLA characteristics among Zhuang-Dong language-speaking populations

“…For example, the predominant A-C-B haplotype, A*02:07-C*01:02-B*46:01, was predominant in Vietnamese as well as in some southern Chinese populations, such as the Dai, Hani, Miao, Bouyei, Shui, Han in Yunnan, and Han in Guangdong, but existed at low frequencies in Chinese Hui, Japanese, and Koreans. Another predominant haplotype, A*11:01-C*08:01-B*15:02, was also predominant in Vietnamese and some Chinese populations, such as the Bulang, Dai, Hani, Shui, Han in Yunnan, and Han in Guangdong, who were located in southern China (Tokunaga et al, 1997;Middleton et al, 2004;Chen et al, 2007;Hong et al, 2007;Ogata et al, 2007;Trachtenberg et al, 2007;Hoa et al, 2008;Shi et al, 2008;2010a;2010b;Wen et al, 2008;Yao et al, 2009). Based on the HLA alleles, haplotypes, and neighbor-joining tree analysis, we concluded that the Zhuang is a typical southern Chinese population.…”

New Testing Approach in HLA Genotyping Helps Overcome Barriers in Effective Clinical Practice

“…In addition, the conventional test's long TAT delays drug treatment and disease control. Although testing for HLA-B*1502 is most relevant for patients in Asia [where the B*1502 carrier rate is high (13 )], many Asian countries have poor healthcare resources and cannot afford the conventional genotyping test (Table 1). Thus, an urgent need exists for a rapid diagnosis at a low cost.…”

Distribution of HLA alleles and haplotypes in Jinuo and Wa populations in Southwest China

“…Principal component analysis was also performed based on HLA-A, -B, and -DRB1 allele frequencies. Frequency data for other Asian populations were obtained from previous studies as follows: Chinese Xiamen Han and Taiwanese [9]; Chinese Korean, Chinese Manchu, Japanese, and Mongolian [10]; Chinese Buyi [11]; Chinese Tibetan [12,13]; Chinese Xibai Han [14,15];Chinese Ugur [13,15]; Chinese Tibetan [12,13]; Chinese Xibai Han [14,15]; Singapore Chinese [16]; Korean [17]; Maonan [18]; Yunnan Han and Naxi [19]; Vietamese [20]; Thai, Tai Dam, and Tai Lue [21]; and Minnan and Hakka [22]. Figure 1 shows the geographic distribution of the areas inhabited by these 22 Asian populations.…”