HLA Antigens in Three Common Populations in South East Asia — Chinese, Malay and Filipino

Abstract

The HLA profiles of three common populations from South East Asia, Chinese and Malays from Singapore and Filipinos from the Philippines are documented.

HLA antigens in Bali (Indonesia) with a special reference to an isolated community

“…Concerning significance of the association Al/B17 in the Balinese population, two hypotheses are suggested: 1) this haplotype is favoured by a still unknown selection mechanism and is therefore found in such diverse populations; or 2) its presence in Bali is a trace of Indian or Vietnamese migrations (this haplotype has a frequency up to 3% in these two populations) which is compatible with historical facts. A similar argument may be put forward for the association Aw33JB12 which is also found in Malays (Chan et al 1979). On the other hand, the association AllJB13 has only been found in our series but this haplotype is frequent (12%) in a New Guinean population from Kar Kar Island in New Guinea (Morris et al 1972).…”

“…On the other hand, the association AllJB13 has only been found in our series but this haplotype is frequent (12%) in a New Guinean population from Kar Kar Island in New Guinea (Morris et al 1972). Negative linkage disequilibria found in Bali are also common in neighbouring populations: A9JB12 in Malays and A9JB17 in Filipinos (Chan et al 1979).…”

“…Malays from Singapore (N = 106). Chan et al 1979. the HLA -A, -B profile of the Mongoloid populations of South-East Asia presents a number of common characteristics: high frequency of alleles A9 (Aw24), A2, A l l , B5, B15, Bw35, B40, and absence or very low frequency of alleles A l , A3 . Aw23, A 25, A 29, B8, B14, Bw21, Bw22.…”

The HLA system in the prevalent Mexican Indian group: the Nahuas

“…A fascinating topic is still the mystery of the original ancestors of the Nahuas. In a precarious attempt to answer this question, we reviewed Chinese (Mineter et al 1981), Viet-namese (Tran et al 1978) Filipino and Malay (Chan et al 1979, Korean (Albert et al 1973) and Japanese (Baur & Danilovs 1980) as indicative of some of the many Mongoloid groups. It is clear from the gene frequencies that the HLA profile in each population is different, and according to the distribution, most of the frequent antigens in Malay and Filipino are also the prevailing antigens in Nahuas.…”

HLA polymorphisms in a Han Chinese population of Sichuan

“…There are more than 100 million inhabitants living in this province and the majority of them is Han Chinese. As yet there has been little information concerning the distribution of HLA polymorphisms of Chinese (Jaraquemada et al 1984, Chan et al 1979, Miniter et al 1981) and this is not from the Sichuan population.…”