The HLA system in the prevalent Mexican Indian group: the Nahuas

Gorodezky, Clara; Castro‐Escobar, L. E.; Escobar‐Gutiérrez, Alejandro

doi:10.1111/j.1399-0039.1985.tb00410.x

Cited by 19 publications

(3 citation statements)

References 14 publications

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“…HLA‐A*020101‐B*4801 has been also reported in Mexican Mestizo population (37). The haplotypes HLA‐ Cw*0304‐B*4002, ‐Cw*0304‐B*4005, ‐Cw*040101‐B*3501/02/03 and ‐Cw*0801‐B*4801 have been also reported previously in other populations, including the Mexican Mestizo (37), HLA‐Cw*040101‐B*3501/02/03 is common in Nahua Amerindian population (38). HLA‐Cw*0102‐B*1501 and ‐Cw*020202‐B*270502 have been also reported in the Yup'ik Alaskan natives, the first one with a frequency of 0.6%, compared with 13.6% in the Tarahumara population, and the second one with 10.7% compared with 3.6% (39).…”

Section: Resultssupporting

confidence: 73%

High‐resolution molecular characterization of the HLA class I and class II in the Tarahumara Amerindian population

et al. 2006

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We describe for the first time the high-resolution profiling of HLA-A, -B, -C, -DRB1, -DQB1 and -DPB1 in a culturally and geographically distinct Mexican ethnic group, the Tarahumaras. The alleles most frequently found by reference strand-mediated conformational analysis in this population were for class I: HLA-A*240201, *020101/09, *0206, *310102, *680102; HLA-B*4002, *1501, *510201, *3501/02/03, *4005, *4801; HLA-Cw*0304, *0801, *0102, *040101; and for class II: HLA-DRB1*080201, *1402, *040701; HLA-DQB1*0402, *0301, *0302/07; HLA-DPB1*0402, *0401, *020102. In addition, a novel allele, HLA-A*0257, was found. Based on comparison of presently known HLA-DRB1 and -DQB1 allele frequencies in Amerindian groups and worldwide populations, the Tarahumaras are unexpectedly more related to the geographically and linguistically distant Aymara and Terena Amerindian groups than they are to neighbouring tribes.

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Section: Resultssupporting

confidence: 73%

High‐resolution molecular characterization of the HLA class I and class II in the Tarahumara Amerindian population

et al. 2006

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“…Regarding genetic factors, LAC populations are very heterogeneous, and while Argentina and Uruguay have the largest Caucasian influence, numerous LAC inhabitants are racially constituted by mestizos, a complex admixture of Caucasian and Amerindian peoples. 50 In this group certain genes appear to emerge as protective factors against MS. Likewise, protection or resistance has also been observed in similar ethnic groups, such as Canadian aboriginals and Japanese cohorts.…”

Section: Discussionmentioning

confidence: 99%

The epidemiology of multiple sclerosis in Latin America and the Caribbean: a systematic review

et al. 2012

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The incidence and prevalence of multiple sclerosis (MS) varies geographically as shown through extensive epidemiological studies performed mainly in developed countries. Nonetheless, scant data is available in Latin America and the Caribbean (LAC). The objective of this review is to assess epidemiological data of MS in LAC. We conducted a systematic review of published articles and gray literature from January 1995 to May 2011. Twenty-two studies met the inclusion criteria after full-text review. Incidence data were found in only three studies and ranged from 0.3 to 1.9 annual cases per 100,000 person-years. Prevalence was reported in 10 studies and ranged from 0.83 to 21.5 cases per 100,000 inhabitants. The most prevalent subtype of MS was the relapsing-remitting form (48% to 91% of the series). No data about mortality were found. This study showed low frequency for MS in LAC compared with North American and European countries. The role of environmental and genetic factors should be well studied, providing new insights about its etiology.

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“…Different studies of MHC class-I and class-II alleles in Amerindian populations have been carried out for anthropological as well as evolutionary studies (Layrisse et al , 1973; Kostyu and Amos 1981; Williams et al , 1981; Vullo et al , 1984; Gorodezky et al , 1985; Long et al , 1991; Petzl-Erler et al , 1993; Tsuneto et al , 2003; Parolin and Carnese 2009; Arnaiz-Villena et al , 2010, 2011; Vargas-Alarcon et al , 2011). New MHC class I and class II alleles have been identified in North and South Amerindian communities (Belich et al , 1992; Watkins et al , 1992; Zhang et al , 1993; Layrisse et al , 1997; Mack and Erlich 1998).…”

Section: Introductionmentioning

confidence: 99%

MHC Class II haplotypes of Colombian Amerindian tribes

Yunis

Yunis³

2013

Genet. Mol. Biol.

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We analyzed 1041 individuals belonging to 17 Amerindian tribes of Colombia, Chimila, Bari and Tunebo (Chibcha linguistic family), Embera, Waunana (Choco linguistic family), Puinave and Nukak (Maku-Puinave linguistic families), Cubeo, Guanano, Tucano, Desano and Piratapuyo (Tukano linguistic family), Guahibo and Guayabero (Guayabero Linguistic Family), Curripaco and Piapoco (Arawak linguistic family) and Yucpa (Karib linguistic family). for MHC class II haplotypes (HLA-DRB1, DQA1, DQB1). Approximately 90% of the MHC class II haplotypes found among these tribes are haplotypes frequently encountered in other Amerindian tribes. Nonetheless, striking differences were observed among Chibcha and non-Chibcha speaking tribes. The DRB1*04:04, DRB1*04:11, DRB1*09:01 carrying haplotypes were frequently found among non-Chibcha speaking tribes, while the DRB1*04:07 haplotype showed significant frequencies among Chibcha speaking tribes, and only marginal frequencies among non-Chibcha speaking tribes. Our results suggest that the differences in MHC class II haplotype frequency found among Chibcha and non-Chibcha speaking tribes could be due to genetic differentiation in Mesoamerica of the ancestral Amerindian population into Chibcha and non-Chibcha speaking populations before they entered into South America.

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The HLA system in the prevalent Mexican Indian group: the Nahuas

Cited by 19 publications

References 14 publications

High‐resolution molecular characterization of the HLA class I and class II in the Tarahumara Amerindian population

High‐resolution molecular characterization of the HLA class I and class II in the Tarahumara Amerindian population

The epidemiology of multiple sclerosis in Latin America and the Caribbean: a systematic review

MHC Class II haplotypes of Colombian Amerindian tribes

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