HLA antigens in Italian multiple sclerosis patients

Mantia, L. La; Illeni, Maria Teresa; Milanese, C.; Salmaggi, Andrea; Eoli, Marica; Pellegris, G; Nespolo, A.

doi:10.1007/bf02337618

Cited by 13 publications

(5 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If DR antigens themselves are directly involved in susceptibility to CNMS, the finding of DR4 association among patients of Mediterranean origin versus DR2 association in North Europe and North America may support the idea that MS within Europe is a heterogenous condition. Further studies of MS patients from the Mediterranean area seem indicated also because some studies of patients from Northern Italy indicate an association to B7 in patients with a progressive course, but with no association to DR2 or DR4 (24).…”

Section: Discussionmentioning

confidence: 99%

Multiple sclerosis in the Faroe Islands VI. Studies of HLA markers

Jersild

Riisom

et al. 1993

Tissue Antigens

View full text Add to dashboard Cite

Occurrence of clinical neurologic multiple sclerosis (CNMS) among resident Faroese began between 1943 and 1973 and comprised three epidemics. The occupation by British forces for 5 years during World War II was interpreted to have been of major importance for the Occurrence of these epidemics and led us to believe that CNMS is the rare, late result of a single, widespread, systemic and specific infectious disease which we have labelled the primary MS affection (PMSA). In this study we describe the occurrence of genetic markers of the HLA system in 16 Faroese MS patients, 25 of their siblings, 30 unrelated healthy neighbors and spouses to MS patients, 18 healthy controls from areas where no MS cases have been detected, and 80 unrelated normal Faroese. These studies show no significant deviations of HLA class I antigens, whereas the class II antigens do deviate: 50% of the Faroese MS patients carry the HLA‐DR2 (DQ1/DRB 15) antigen, compared to a frequency of 15–20% among the control groups. Also the group of siblings of MS patients showed an increased frequency of DR4 (72%) compared to normal frequency among MS patients and other normal controls (43–47%). However, if DR15‐positive individuals were excluded, this difference was further reduced. If PMSA was widespread within this group, DR4 or some closely associated genetic marker may confer protection against PMSA developing into CNMS. The occurrence of CNMS in these epidemics seems therefore associated to HLA class II‐linked genetic factors similar to those found in studies of other caucasians with MS. This observation seems important in understanding the pathogenesis of this disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Multiple sclerosis in the Faroe Islands VI. Studies of HLA markers

Jersild

Riisom

et al. 1993

Tissue Antigens

View full text Add to dashboard Cite

show abstract

“…The precise patho gene sis is unclear. Recent studies support the ideas that certain human leucocytlocu s A (HLA) haplotypes imply increased susceptibility to multiple sclerosis (1)(2)(3)(4)(5) and that infection s (6)(7)(8)(9)(10)(11)(12)(13)(14)(15), for example , retro virus (16)(17)(18) , may play a role in the patho genesis. There are several observations regarding the associated occurrence of multipl e sclerosis with other autoimmune disorders ( 19), like myas then ia gravis (20), thyroid disease (2 1), and Sjogren ' s syndrome (22), but also with such clearly HLA-Iinked conditions as ankylosing spondylitis (23) and narcolepsy (24,25 ).…”

mentioning

confidence: 80%

Multiple sclerosis and exposure to solvents, ionizing radiation and animals.

Landtblom¹,

Flodin²,

Karlsson³

et al. 1993

Scand J Work Environ Health

View full text Add to dashboard Cite

“…The present results for A23 allele are coherent with the study of HLA genes in MS patients in Italy. 17 La Mantia et al showed that the occurrence of A23, A26, Cw4, DR3 and DR5 alleles were significantly higher in MS patients than in controls. 17 We also have found that the prevalence of B51 allele in the normal population is much higher than in the ON patients in the present study (Table 1).…”

Section: Resultsmentioning

confidence: 98%

“…17 La Mantia et al showed that the occurrence of A23, A26, Cw4, DR3 and DR5 alleles were significantly higher in MS patients than in controls. 17 We also have found that the prevalence of B51 allele in the normal population is much higher than in the ON patients in the present study (Table 1). The logistic model shows a negative correlation between this allele and the development of ON (OR 0.05, 95% CI 0.00 Á/0.38, P B/ 0.004; Table 5).…”

Section: Resultsmentioning

confidence: 98%

Influence of HLA on progression of optic neuritis to multiple sclerosis: results of a four-year follow-up study

et al. 2004

View full text Add to dashboard Cite

The study strongly suggests the association among DR2, A23 and B21 allele and the evolution of ON to MS. High prevalence of A23 and DR2 alleles in CDMS patients compared with the normal population may suggest an important role for these alleles in the development of MS. The study suggests B51 as a protective factor against development of ON in the normal population. In addition, results do not confirm previous studies considering A11 as a predisposing factor. The present study finally evokes that different classes of HLA have different roles in susceptibility to MS and confirms disease heterogeneity as an important emerging concept in MS.

show abstract

HLA antigens in Italian multiple sclerosis patients

Cited by 13 publications

References 27 publications

Multiple sclerosis in the Faroe Islands VI. Studies of HLA markers

Multiple sclerosis in the Faroe Islands VI. Studies of HLA markers

Multiple sclerosis and exposure to solvents, ionizing radiation and animals.

Influence of HLA on progression of optic neuritis to multiple sclerosis: results of a four-year follow-up study

Contact Info

Product

Resources

About