Influence of HLA on progression of optic neuritis to multiple sclerosis:                 results of a four-year follow-up study

Kheradvar, Arash; Tabassi, Abdol Reza; Nikbin, Behrouz; Khosravi, Farideh; Naroueynejad, Mehrnaz; Moradi, Babak; Amirzargar, Ali Akbar

doi:10.1191/1352458504ms1077oa

Cited by 8 publications

(5 citation statements)

References 17 publications

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“…Notably, in contrast to HLA-A3, other members of the A3 superfamily (HLA-A11, HLA-A3301, HLA-A3101 and HLA-Aw*6801), which by definition share peptide-binding properties with HLA-A3, do not appear to be associated with MS (Harbo et al, 2004;Kheradvar et al, 2004). A report of a modest predisposing effect of HLA-A11 in the Indian popu-lation was tempered by the particular small sample group studied (Kankonkar et al, 2003).…”

Section: Introductionmentioning

confidence: 91%

Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis

McMahon

Friis

Siebold

et al. 2011

Acta Crystallogr D Biol Crystallogr

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Section: Introductionmentioning

confidence: 91%

Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis

McMahon

Friis

Siebold

et al. 2011

Acta Crystallogr D Biol Crystallogr

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“…Several studies have suggested that HLA-B51, HLA-DR, and HLA-A11 may be protective in patients with ON against progression to MS [21,22]. The data on HLA-A11 have been difficult to replicate in some studies [23].…”

Section: Pathology and Immunologymentioning

confidence: 99%

New directions in optic neuritis and multiple sclerosis

Gilbert

Sergott

2007

Curr Neurol Neurosci Rep

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Optic neuritis (ON) is the initial presentation in 15% to 20% of cases of multiple sclerosis (MS). Thirty-eight percent to 50% of patients with MS develop ON at some point during the course of their disease. The Optic Neuritis Treatment Trial (ONTT) provided much prospective data about the clinical presentation, clinical course with respect to treatment, and development of MS in patients with ON. The clinical course of MS initially involves episodes of demyelination followed by full recovery; however, later attacks often leave persistent deficits that lead to secondary progression of the disease. The risk of developing progressive neurologic deficits can be reduced by starting therapy with immunomodulating drugs early in the course of the disease. Optical coherence tomography is a noninvasive way to monitor patients with ON to determine if they are undergoing subclinical axonal loss of ganglion cells. Progression of axonal loss on optical coherence tomography may prompt a change in therapy or further imaging.

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“…A number of factors explain the link between ON and MS. These factors include abnormal cerebrospinal fluid (CSF) at the onset of ON (Sandberg-Wollheim et al 1990;Klistorner et al 2009), certain human leukocytes antigen (HLA) types (Frith et al 2000;Kheradvar et al 2004), and brain magnetic resonance imaging (MRI) lesions, which are frequently present in patients with ON (Jin et al 2003;Optic Neuritis Study Group 2008). A recent study indicated that Tau protein may be a possible prognostic factor in ON and MS (Frederiksen et al 2012).…”

Section: Introductionmentioning

confidence: 99%

A Nine-Year Population-Based Cohort Study on the Risk of Multiple Sclerosis in Patients with Optic Neuritis

Woung

Peng

Liu

et al. 2013

Tohoku J. Exp. Med.

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Patients with optic neuritis (ON) are at an increased risk of developing multiple sclerosis (MS), an illness that may result in physical dysfunction and short life expectancy. Information on the conversion rate to MS of patients with ON is essential in determining the impact of ON on the incidence of MS. Previous Taiwanese studies on the risk of MS in patients with ON were all hospital based, thereby limiting the generalizability of the findings. We aimed to estimate the risk of MS in patients with ON using a nationally representative sample. A cohort of 2,741 patients who sought outpatient care for ON in 2000 was identified from Taiwan's National Health Insurance claims. The control group consisted of 27,330 age- and sex-matched subjects randomly selected from all beneficiaries in 2000. The person-year approach with Poisson assumption was used to estimate the incidence rate of MS from 2000 to 2008. The relative risk of outpatient visit or hospitalization for MS was estimated using the Cox proportional hazard model. The incidence rates of MS in the ON and control groups were 25.6 and 0.4, respectively, per 10,000 person-years; these values represent a relative risk estimate of 30.84 (95% confidence interval: 14.48 to 65.73) after the potential confounders were considered. Female or younger patients with ON were associated with a significantly elevated risk of developing MS. This study found that Taiwanese patients with ON are at a substantially high relative risk of developing MS. In addition to patients with ON, female and younger people should also receive intensive neurological care to further reduce their risk of developing MS.

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Influence of HLA on progression of optic neuritis to multiple sclerosis: results of a four-year follow-up study

Cited by 8 publications

References 17 publications

Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis

Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis

New directions in optic neuritis and multiple sclerosis

A Nine-Year Population-Based Cohort Study on the Risk of Multiple Sclerosis in Patients with Optic Neuritis

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