HLA antigens and anti-sperm antibody production in Iranian vasectomized men

Azizi, Gholamreza; Namaki, Saeed; Mirshafiey, Abbas; Hamid, Kabir Magaji

doi:10.7555/jbr.29.20140113

Cited by 2 publications

(5 citation statements)

References 6 publications

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“…This type of procedure can lead to an immunogenic response thus initiating the production of ASA (Marconi & Weidner 2017). The association between vasectomy and ASA production is well documented (Gubin et al 1998, Marconi et al 2008, Lee et al 2009, Azizi et al 2015.…”

Section: Vasectomymentioning

confidence: 97%

“…Despite its potentially high relevance, it is not currently possible to clearly state that the etiology of ASA has been fully characterized. It is generally accepted that developmental abnormalities in the blood-testis barrier (BTB) formation as well as its weakness, damage, and/or disruption can lead to the appearance of ASA (Chamley & Clarke 2007, Azizi et al 2015, Brincat et al 2015, Xu et al 2020 due to the exposure of immunogenic sperm antigens to immunocompetent cells from the immune system (Mazumdar & Levine 1998). In fact, some conditions which are associated, at least to some extent, with the integrity of the BTB, and can also be possible risk factors for ASA development as we will further discuss, have gained attention in the study of ASA-mediated male infertility.…”

Section: Antisperm Antibodies Etiologymentioning

confidence: 99%

“…In fact, this is one of the most accepted risk factors associated with ASA generation (Marconi & Weidner 2017). Additionally, it was recently reported that the predisposition for ASA production in vasectomized men seems to be associated with some molecules of the human leukocyte antigen (HLA) system, with men having lower serum ASA levels presenting specific HLA antigens, such as HLA-A2, HLA-B5, HLA-DR53, and HLA-DQ2 (Azizi et al 2015). However, the threshold that used to define ASA positivity was not mentioned (Supplementary Table 2), and the relationship between HLA antigens and ASA production requires additional research since a strong association between other HLA antigens (HLA-A28) with ASA production after vasectomy was also reported (Law et al 1979).…”

Section: Vasectomymentioning

confidence: 99%

“…Of the several causes of male infertility, the presence of antisperm antibodies (ASA) leads to so-called immune infertility, an autoimmune disease of the reproductive system with low documented prevalence (Bohring & Krause 2003, Dohle et al 2010, Cui et al 2015, Jungwirth et al 2019. Antisperm antibodies are immunoglobulins that interact with sperm antigens, hindering the function of the male gamete, and thus playing a role in fertility (Azizi et al 2015). In fact, it has been described that the presence of these antibodies can be involved in male fertility impairment (Zini et al 2010, Bozhedomov et al 2014a, Verón et al 2016, Al-Daghistani 2020.…”

Section: Introductionmentioning

confidence: 99%

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The impact of antisperm antibodies on human male reproductive function: an update

2021

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Immune infertility occurs due to the presence of antisperm antibodies (ASA). This type of infertility has a relatively low prevalence (2.6-6.6% in infertile men), and its etiology, risk factors, targets and consequences for male fertility are not completely understood. While it is largely accepted that abnormalities in the blood-testis barrier and/or blood-epididymal barrier are the main factors behind its etiology, and that sperm motility is the most frequently reported altered parameter, few are the well-defined risk factors and ASA targets only now started to be disclosed, with proteins involved in sperm-oocyte interaction rising as the most significant. The development of potential treatments is also limited, being the corticosteroids the more promising. Overall, there are still many knowledge gaps related to immune infertility. With this review we aimed to gather all the information collected from studies developed in humans in the last decade. Despite the controversial results/inconsistencies, that are not only a result from the complexity of mechanisms/variables involved in ASA infertility, but also from the technical approaches to assess ASA and the lack of a consensus regarding the thresholds to be used, this manuscript aims to bring a fresh update on the field. It has become clear that, to obtain more/reliable data, there is a need to assess ASA in all the routine seminal analysis, following WHO recommendations. In this way it will be possible to obtain consistent and comparable information, that can add to current knowledge. Additionally, multicentric studies with large cohorts are also missing, and future research should take this into consideration.

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Section: Vasectomymentioning

confidence: 97%

Section: Antisperm Antibodies Etiologymentioning

confidence: 99%

Section: Vasectomymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The impact of antisperm antibodies on human male reproductive function: an update

2021

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“…Couples who fail to conceive after 1 or more years of regular, unprotected sexual intercourse are defined as infertile by the World Health Organization (WHO) 1 2 . Anti-sperm antibodies (ASAs) interact with numerous sperm antigens that perform functions in fertility, markedly decreasing the chance of pregnancy by reducing sperm count, motility, and viability, leading to male or female ‘immune infertility’ 3 4 5 6 7 8 9 .…”

mentioning

confidence: 99%

Immune Infertility Should Be Positively Diagnosed Using an Accurate Method by Monitoring the Level of Anti-ACTL7a Antibody

Yao

Luo

et al. 2016

Sci Rep

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Infertility is currently a major public health problem. Anti-sperm antibodies (ASAs) markedly reduce sperm quality, which can subsequently lead to male and/or female infertility. The accurate detection of ASAs derived from specific spermatozoa is, therefore, clinically useful. We have focused on the spermatozoa-specific expression protein ACTL7a for many years and have developed an enzyme-linked immunosorbent assay (ELISA) to detect the concentration of anti-ACTL7a antibodies in fertile sera (n = 267) and infertile sera (n = 193). Infertile sera were collected from the positive sera of tray agglutination tests (TAT), which is a routine ASA screening methodology. We found that the concentration of anti-ACTL7a antibodies was significantly higher in the infertile sera (than in the fertile sera, P < 0.0001) and much higher in the TAT ≥ 16 infertile sera. The ELISA was much better for male sera detection (AUC = 0.9899). If we set the standard at a strongly positive value (calculated by ROC curve), the positive predictive value of the antibody detection reached 100 percent, with a false positive rate of zero. The developed ELISA method for anti-ACTL7a antibody detection is therefore sensitive, accurate, and easy to perform, making it an excellent potential tool for future clinical use.

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HLA antigens and anti-sperm antibody production in Iranian vasectomized men

Cited by 2 publications

References 6 publications

The impact of antisperm antibodies on human male reproductive function: an update

The impact of antisperm antibodies on human male reproductive function: an update

Immune Infertility Should Be Positively Diagnosed Using an Accurate Method by Monitoring the Level of Anti-ACTL7a Antibody

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