Immune Infertility Should Be Positively Diagnosed Using an Accurate Method by Monitoring the Level of Anti-ACTL7a Antibody

Fu, Jun; Yao, Rongyan; Luo, Yuejun; Yang, Dantong; Cao, Yanxiang; Yi, Qiu; Song, Wei; Miao, Shiying; Gu, Yuan; Wang, Linfang

doi:10.1038/srep22844

Cited by 14 publications

(11 citation statements)

References 30 publications

(34 reference statements)

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“…On the other hand, Fu et al 22 recently developed an enzyme‐linked immunosorbent assay (ELISA) using anti‐actin‐like protein (ACTL)7a antibodies because they thought that previously available tests of ASA detection showed only the binding of antibodies on the sperm surface, but no antigenic information could be applied 23‐25 . They have focused on the sperm‐specific expression protein ACTL7a and found that ACTL7a could be recognized by the antibodies contained in infertile serum, which could reduce mouse fertility rates to zero 26 .…”

Section: Detection Of Anti‐sperm Antibodiesmentioning

confidence: 98%

“…If they set the standard at a strongly positive value, calculated by ROC curve, the positive predictive value of the antibody detection reached 100 percent, with a false‐positive rate of zero. They concluded that the ELISA method developed for anti‐ACTL7a antibody detection is therefore sensitive, accurate, and easy to perform, making it an excellent potential tool for future clinical use 22 …”

Section: Detection Of Anti‐sperm Antibodiesmentioning

confidence: 99%

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Anti‐sperm antibodies and reproductive failures

Shibahara

Wakimoto

Fukui

et al. 2020

American J Rep Immunol

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Reproductive failures include infertility and recurrent pregnancy loss (RPL). Although the relative importance of immunological factors in human reproduction remains unclear, there may be immune‐mediated reproductive failures in a portion of unexplained infertility and RPL. As a cause of immunological factor, anti‐sperm antibodies (ASA) are produced both in men and women. There have been reported several antigens in the surface of sperm that are especially foreign to women. The presence of ASA, especially sperm‐immobilizing antibodies, in the sera of infertile women has been shown to inhibit sperm migration in the female genital tract. Therefore, the effectiveness of the treatments for infertile women with sperm‐immobilizing antibodies by timed intercourse or intra‐uterine insemination is limited. Such antibodies can also exert inhibitory effects on various stages of sperm‐egg interaction and subsequent embryo development in vitro. It is suggested that ASA testing for infertile women should be performed before proceeding IVF. The manipulation of gametes and embryos from patients having sperm‐immobilizing antibodies should be carefully carried out especially to avoid contaminating patient's serum and follicular fluid in the culture medium in order to overcome the immunological causes of female infertility by ASA, and satisfactory results under suitable conditions for gametes and embryos have been obtained. The relationship between ASA and RPL was controversially reported. Increased miscarriage rates in women with ASA were demonstrated by some authors. In contrast, lack of association between ASA and RPL was reported. In this manuscript, we are focusing the roles of ASA in women with reproductive failures.

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Section: Detection Of Anti‐sperm Antibodiesmentioning

confidence: 98%

Section: Detection Of Anti‐sperm Antibodiesmentioning

confidence: 99%

Anti‐sperm antibodies and reproductive failures

Shibahara

Wakimoto

Fukui

et al. 2020

American J Rep Immunol

View full text Add to dashboard Cite

show abstract

“…The spontaneous pregnancy rates in these two groups followed the same pattern, being 20% in the ASAnegative controls and 6.5 % in the ASA-positive patients. 114 Additional new, sensitive technologies for monitoring the presence of ASA in semen and blood 116,117 that target specific antigens 118,119 may provide this field with the additional stimulus it needs to become a valid component of our diagnostic armamentarium.…”

Section: Autoimmunity Inflammation and Infectionmentioning

confidence: 99%

The Male Is Significantly Implicated as the Cause of Unexplained Infertility

Aitken

2020

Semin Reprod Med

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Male infertility is recognized as a relatively common, complex condition, generated by a broad array of environmental and genetic factors. Historical reliance on the conventional semen profile has tended to underestimate the true contribution of “the male factor” to human infertility. This review highlights the importance of genetic and epigenetic factors in the etiology of male infertility, identifying a range of mutations responsible for primary testicular failure and impaired fertilizing potential. More than three quarters of all de novo mutations arise in the male germline via mechanisms that involve the inefficient or defective repair of DNA damage. Understanding the range of factors capable of creating genetic turmoil in the paternal germline is essential, if we are to gain a deep understanding of the causes of male infertility, rather than just the symptoms that characterize its presence. High levels of DNA fragmentation induced by oxidative stress are part of this equation. Oxidative stress is, in turn, driven by biological (age, ejaculation frequency, varicocele, infection), lifestyle (smoking, obesity), and environmental factors (heat, other forms of electromagnetic radiation, and toxins) that can impair the fertilizing potential of the spermatozoa and influence the incidence of spontaneous mutations that may cause infertility in the offspring.

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“…However, this production-related issue is studied insufficiently. There are numerous violations in the animal management and feeding, their technological exploitation and artificial fertilization which leads to suppression of the reproductive cycle in sows due to alimentary and symptomatic infertility, fertilization disruptions due to an increased sperm antibody titer, which is characteristic of the immune infertility [1,2].…”

Section: Introductionmentioning

confidence: 99%

Releasing Hormone and Vitamin Efficiency in the Treatment of Obstetric and Gynecological Pathologies in Breeding Sows

Chekan

Khilko

2020

Technology transfer: innovative solutions in medicine

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Reproduction is a crucial issue at the present stage in the pig husbandry development. Infertility of breeding sows leads to excessive use of feed, increased costs associated with failed inseminations, insufficient breed and early culling of sows. Aim of the research. Study of infertility types and prevention of postpartum diseases in sows in order to develop methods to control them. Methods. A two-stage experiment was carried out in 2019–2020 at the LLC "Ryasnyanske" farm in Sumy region, Ukraine. The first stage involved development of a method for prevention and control of infertility in sows. The second stage focused on the method of postpartum pathology prevention. Results. The conducted research established that surfagon and vitamins manifested the highest efficiency in case of alimentary infertility as they increased fertilization by 20.8 %. In terms of symptomatic infertility, the best results were achieved through a combined use of surfagon and gonadotropic hormone for both primary and multiple fertilization of sows, especially considering extremely low values in the control group - 15 % and 6.5 % of piglets, respectively. Aminazine proved to be the most effective remedy for immune infertility, the obtained results were 17.2 % higher than in the control group. Surfagon at a dose of 5 ml together with estrofan twice a day fully prevented inflammatory postpartum pathologies in sows. Conclusions. Pathologies of the reproductive organs in sows are widespread at pork-producing farms. Individual use of surfagon was justified for treatment of alimentary, symptomatic and immune infertility of sows and prevention of postpartum pathologies. A combined use of tissue therapy and biologically active drugs proved to be the most effective. The treatment regimens described above reduce infertility and prevent postpartum pathologies in sows.

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Immune Infertility Should Be Positively Diagnosed Using an Accurate Method by Monitoring the Level of Anti-ACTL7a Antibody

Cited by 14 publications

References 30 publications

Anti‐sperm antibodies and reproductive failures

Anti‐sperm antibodies and reproductive failures

The Male Is Significantly Implicated as the Cause of Unexplained Infertility

Releasing Hormone and Vitamin Efficiency in the Treatment of Obstetric and Gynecological Pathologies in Breeding Sows

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