HLA antigen in three types of glomerulonephritis

IgA Nephropathy in Japan

“…In two reports from France [1,2], an association of IgA nephropathy with HLA DW35 was noted, but this obser vation was not confirmed by others [3,4], We did not find any relationships between HLA loci A and B anti gens and IgA nephropathy. However, Tsuchida [5] found a significant association of HLA DRW4 with IgA ne phropathy.…”

Recurrence of Type I Membranoproliferative Glomerulonephritis After Renal Transplantation

“…How ever, the difference in the recurrence rate between recipients of cadaveric and identical living related donor grafts did not reach statistical significance, possibly due to the small num ber of patients. It is known th at patients with IgA nephrop athy have a higher risk of recurrent disease when receiving a kidney from a living related donor (19)(20)(21). This information is not available for patients with type I MPGN, although two studies suggest th a t all forms of glomerulonephritis are more likely to occur in recipients of a living related donor graft (3,18).…”

Hla antigens in essential mixed cryoglobulinemia

“…Other HLA antigens have been found to be increased in some renal diseases, such as IgA nephropathy (19)(20)(21) or poststreptococcal glomerulonephritis (22). It was suggested that in these conditions they could influence the nephrotoxicity of circulating immune complexes, affect the host response to the offending antigens (19), or modify target organ structure The present evidence, however, of the possible influence of the HLA system over single aspects of essential mixed cryoglobulinemia is far from being conclusive. Family studies and investigations of a larger number of patients have been planned to identify the patients at high risk for the most serious complications of this disorder.…”