IgA Nephropathy in Japan

Glassock, Richard J.; Kurokawa, Kiyoshi; Yoshida, Masahiko; Sakai, Osamu; Okada, Masaaki; Shigematsu, Hidekazu; Ohno, Joji; Sakai, Hideto

doi:10.1159/000166919

Cited by 21 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings suggest that the activation of the alternative complement pathways is involved in IgA nephropathy [10]. Several studies have assessed systemic complement activation in patients with IgA nephropathy by measuring the complement breakdown products [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Significance of Glomerular Deposition of C3c and C3d in IgA Nephropathy

et al. 2000

View full text Add to dashboard Cite

Background: Complement activation plays an important role in the pathogenesis of IgA nephropathy. The clinico-pathological significance of the glomerular deposition of complement breakdown products, C3c and C3d in IgA nephropathy remains to be clarified. Methods: We examined the relationship between glomerular staining patterns of C3c and C3d and clinico-pathological findings with 163 patients with IgA nephropathy. Renal biopsy specimens were stained with C3c and C3d by immunofluorescence, and patients were divided into the following two groups: the intensity of C3c deposition stronger than C3d deposition, or equal to it (group A); the intensity of C3d deposition stronger than C3c deposition (group B). Results: In group A, the incidence of severe hematuria (over 20 urinary red blood cells in high-power field microscope (×400)) or of higher urinary fibrinogen degenerated products (over 0.1 μg/ml) was significantly higher than that in group B. In addition, group A showed a significant decrease in the glomerular filtration rate. Group A also showed a significantly higher incidence of glomerular endocapillary proliferation than in group B. Conclusion: These findings suggest that the glomerular deposition of C3c is associated with the inflammatory active phase of glomeruli in IgA nephropathy.

show abstract

Section: Introductionmentioning

confidence: 99%

Significance of Glomerular Deposition of C3c and C3d in IgA Nephropathy

et al. 2000

View full text Add to dashboard Cite

show abstract

“…Previous studies have described a number of abnor malities of the IgA immune system in IgAN: increased serum IgA concentration [2], increased in vitro IgA pro duction [3][4][5][6][7][8], decreased IgA-specific suppressor T cell activity [9], increased IgA-specific helper T cell activity [7,10,11], an increased number of IgA-bearing cells [12], a reduced number of CD8-positive cells leading to an ele vated CD4/CD8 ratio [3,13] and the presence of circulat ing IgA immune complex [14,15]. However, the relation ship of these findings to the pathogenesis and progres sion of the disease is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Immune Abnormalities and Clinical Course in Childhood IgA Nephropathy

Iijima

Yoshikawa

Shiozawa

et al. 1990

Nephron

View full text Add to dashboard Cite

Immunoglobulin production by peripheral blood mononuclear cells (PBMC) and lymphocyte subpopulations were studied in 56 children with IgA nephropathy (IgAN) and 22 healthy controls. All the patients had persistent proteinuria at the time of diagnosis, and were divided into three clinical groups on the basis of urinary findings at the time of examination: 27 patients had proteinuria with or without microscopic hematuria (group A; active stage), 9 had microscopic hematuria only (group B; healing stage) and 20 had normal urine (group C; remission stage). PBMC from the patients in group A cultured without mitogenic stimulation produced significantly more IgA and IgG than those from controls (p < 0.05). After polyclonal B cell stimulation with pokeweed mitogen (PWM), PBMC from patients in group A produced significantly more IgA than those from group B (p < 0.05), group C (p < 0.05) or controls (p < 0.01), and produced significantly more IgG than those from group B (p < 0.05) or controls (p < 0.01). However, there was no significant difference in PWM-stimulated IgG production between groups A and C. PWM-stimulated PBMC from patients in group C produced significantly more IgA and IgG than those from controls (p < 0.05). There were no significant differences in lymphocyte subpopulations among groups A, B and C and controls. These findings show that the clinical course of childhood IgAN is correlated with IgA production by PBMC suggesting that overproduction of IgA might be responsible for the pathogenesis of IgAN in children.

show abstract

“…Although clinical resolution of IgA nephropathy with disappearance of all the urinary abnormalities has been reported by many authors [15][16][17][18], to our knowledge spontaneous disappearance of the mesangial deposits of IgA has rarely been clearly described [19][20][21], Some authors [ 15,22] even suggested that once the condition has reached a stage at which it can be diagnosed, the histo logic lesions persist indefinitely. Recently diminution [23,24] and even disappearance of mesangial deposits [24] over a longer period of follow-up has been reported.…”

Section: Discussionmentioning

confidence: 99%

Disappearance of Immune Deposits with EDTA Chelation Therapy in a Case of IgA Nephropathy

Lin

Lim

1992

Am J Nephrol

View full text Add to dashboard Cite

In this report, we describe the development of renal function impairment in a 33-year-old patient with mesangial IgA nephropathy and a history of recent gout. Increased body lead burden was identified with a positive EDTA mobilization test. The patient was treated with 1 g of edetate disodium calcium weekly for 2 months until normalization of urinary lead excretion. Improvement of renal function and proteinuria were noted. It was even more interesting to find that both immunofluorescence and electron microscopy studies of the second biopsy specimen revealed the loss of previous mesangial immune deposits. Our case demonstrated that lead may be a nonspecifically damaging factor related to the deterioration of renal function in patients with preexisting renal disease. Moreover, the disappearance of mesangial immune deposits after chelation therapy has not been previously documented. The pathogenetic basis of this observation is unknown, and its causal relationship with lead requires further elucidation.

show abstract

IgA Nephropathy in Japan

Cited by 21 publications

References 19 publications

Significance of Glomerular Deposition of C3c and C3d in IgA Nephropathy

Significance of Glomerular Deposition of C3c and C3d in IgA Nephropathy

Immune Abnormalities and Clinical Course in Childhood IgA Nephropathy

Disappearance of Immune Deposits with EDTA Chelation Therapy in a Case of IgA Nephropathy

Contact Info

Product

Resources

About