HLA antigen frequencies in systemic vasculitis: increase in HLA‐DR2 in wegener's granulomatosis

Elkon, Keith B.; Sutherland, David; Rees, Andrew J.; Hughes, G. R. V.; Batchelor, J. R.

doi:10.1002/art.1780260118

Cited by 73 publications

(13 citation statements)

References 23 publications

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“…These include associations with major histocompatibility complex (MHC) variants, as well as polymorphisms in genes encoding various proteins including α-1 antitrypsin and cytotoxic T lymphocyte antigen4 (CTLA4) 8. The MHC loci found to have an association with GPA include HLA-DR29 and DR810 as well as HLA-DQw7, HLA-DR3, HLA-DR1 and HLA-DR9 8. The extended haplotype DPB1*0401/RxRB03, in particular, has been shown to have an extremely strong association with GPA (OR=6.41, p=7.13×10 −17 ) 11.…”

Section: Discussionmentioning

confidence: 99%

Familial granulomatosis with polyangiitis: three cases of this rare disorder in one Indoasian family carrying an identical HLA DPB1 allele

Tanna¹,

Salama

Brookes

et al. 2012

Case Reports

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Section: Discussionmentioning

confidence: 99%

Familial granulomatosis with polyangiitis: three cases of this rare disorder in one Indoasian family carrying an identical HLA DPB1 allele

Tanna¹,

Salama

Brookes

et al. 2012

Case Reports

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“…These data are consistent with the reported association of HLA-DR2 (DRB1*1501, DRB1*1502, DRB1*1601, and DRB1*1602) in the pathogenesis of ANCA disease. 11 Patients with DR2 are more likely to have persistently positive ANCA. 12 To validate the data in a different cohort of patients, the Vasculitis Clinical Research Consortium (VCRC) provided us with all available samples from African American patients with vasculitis.…”

mentioning

confidence: 99%

DRB1*15 Allele Is a Risk Factor for PR3-ANCA Disease in African Americans

Cao

Schmitz²,

Yang³

et al. 2011

Journal of the American Society of Nephrology

106

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Anti-neutrophil cytoplasmic autoantibody (ANCA) disease rarely occurs in African Americans and risk factors for the disease in this population are unknown. Here, we genotyped MHC class II alleles and found that, among African Americans, those with proteinase 3-ANCA (PR3-ANCA) had 73.3-fold higher odds of having HLA-DRB1*15 alleles than community-based controls (OR 73.3; 95% CI 9.1 to 591). In addition, a disproportionate number of African American patients carried the DRB1*1501 allelic variant of Caucasian descent rather than the DRB1*1503 allelic variant of African descent. Among Caucasians, those with PR3-ANCA had 2.2-fold higher odds of carrying DRB1*1501 than controls (OR 2.2; 95% CI 1.2 to 4.0). A validation study supported by the Vasculitis Clinical Research Consortium confirmed the strong association between the DRB1*15 allele and PR3-ANCA disease, among African Americans. Furthermore, we found that DRB1*1501 protein binds with high affinity to amino acid sequences of sense-PR3, purportedly an antigenic epitope, and to the amino acid sequence complementary to this epitope in vitro. Peptides of sense-PR3 and complementary-PR3 also bound to TNF-␣-induced surface expression of DRB1*1501 on peripheral neutrophils. Taken together, these data suggest HLA-DRB1*15 alleles contribute to the pathogenesis of PR3-ANCA disease.

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“…Increased frequencies of HLA-B8 (17), HLA-DR2 (18), and HLA-DQ7 (19) and a decreased frequency of HLA-DR13 (20) have been found in Wegener's granulomatosis, and positive associations with HLA-DQ7 (19) and with the HLA-DRB1*0901;DQB1*0303 haplotype have been demonstrated in microscopic polyangiitis (21). However, subsequent studies have failed to confirm most of these associations (22).…”

mentioning

confidence: 99%

HLA–DRB4 as a genetic risk factor for Churg‐Strauss syndrome

Vaglio

Martorana

Maggiore

et al. 2007

Arthritis & Rheumatism

171

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Objective. To explore the association between HLA alleles and Churg-Strauss syndrome (CSS), and to investigate the potential influence of HLA alleles on the clinical spectrum of the disease.Methods. Low-resolution genotyping of HLA-A, HLA-B, and HLA-DR loci and genotyping of TNFA ؊238A/G and TNFA ؊308A/G single-nucleotide polymorphisms were performed in 48 consecutive CSS patients and 350 healthy controls.Results.

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HLA antigen frequencies in systemic vasculitis: increase in HLA‐DR2 in wegener's granulomatosis

Cited by 73 publications

References 23 publications

Familial granulomatosis with polyangiitis: three cases of this rare disorder in one Indoasian family carrying an identical HLA DPB1 allele

Familial granulomatosis with polyangiitis: three cases of this rare disorder in one Indoasian family carrying an identical HLA DPB1 allele

DRB1*15 Allele Is a Risk Factor for PR3-ANCA Disease in African Americans

HLA–DRB4 as a genetic risk factor for Churg‐Strauss syndrome

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