Familial granulomatosis with polyangiitis: three cases of this rare disorder in one Indoasian family carrying an identical HLA DPB1 allele

Rituximab used for simultaneous treatment of PR3‐ANCA positive vasculitis associated with rheumatoid arthritis: A case report

“…Etiologically, the HLA alleles in GPA have been reported as HLADPB1 *04:01. 2,3 In the present case, our patient was found to have HLADPB1 *04:02:01 and *05:01, which were unique to this patient. No vasculitic lesions were observed on the CT in the nasal and maxillary sinuses or in the lung field, despite the symptoms of nasal bleeding, ruling out respiratory involvement.…”

HLA‐DPB1 variant rs3117242 is associated with anti‐neutrophil cytoplasmic antibody‐associated vasculitides in a Han Chinese population

“…Furthermore, previous studies have suggested that the most consistent loci associated with GPA was HLA‐DPB1*0401 . Interestingly, in a recent case of a familial GPA encompassing three Hindu patients (father, daughter and son), all of them shared the identical HLA‐DPB1*0401 allele . Also, it was associated with MPA in dominant models.…”

Familial vasculitides: granulomatosis with polyangitis and microscopic polyangitis in two brothers with differing anti-neutrophil cytoplasm antibody specificity

“…The majority describe familial clusters of patients presenting separated in time, but with similar clinical phenotypes and the same ANCA type. We previously reported three members of an Indo-Asian family with GPA who all presented with ENT and renal involvement [ 5 ]. Hay et al [ 6 ] reported on two siblings with GPA, both with renal and pulmonary involvement, and Sewell and Hamilton [ 7 ] reported a mother and daughter with GPA, both with ENT and renal involvement.…”