HLA Analysis in Patients with Degenerative Diseases of the Temporomandibular Joint

Learreta, Jorge Alfonso; Bono, Andrea Erica; Durst, Andreas C.

doi:10.1179/crn.2011.006

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…Matrix metalloproteinases (MMPs) are major players in ECM developmental and repair processes at both physiological and pathological levels (Murphy et al, 2002). An imbalance between the synthesis and degradation of ECM is a characteristic of degenerative changes in the MCC (Learreta, Bono, & Durst, 2011).…”

Section: Introductionmentioning

confidence: 99%

MMP-3 and MMP-8 in rat mandibular condylar cartilage associated with dietary loading, estrogen level, and aging

Yu¹,

Mursu²,

Typpö³

et al. 2019

Archives of Oral Biology

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Objectives: The structure of the mandibular condylar cartilage (MCC) is regulated by dynamic and multifactorial processes. The aim of this study was to examine the effects of altered dietary loading, estrogen level, and aging on the structure of the condylar cartilage and the expressions of matrix metalloproteinase (MMP) -3 and MMP-8 of rat MCC.Methods: In this study, Crl:CD (SD) female rats were randomly divided into 3 groups according to dietary hardness: hard diet (diet board), normal diet (pellet), and soft diet (powder). In each group, the rats were further divided into 2 subgroups by ovariectomy at the age of 7 weeks. The rats were sacrificed at 5-and 14-month-old.Histomorphometric analysis of the MCC thickness was performed after toluidine blue staining. Immunochemical staining was done for MMP-3 and MMP-8. A linear mixed model was used to assess the effects of dietary loading, estrogen level, and aging.Results: Increased dietary loading was the main factor to increase the MMP-3 expression and the anterior and central thickness of the MCC. Lack of estrogen was the main factor associated with decreased MMP-8. Aging was associated with the thickness changes of the whole condylar cartilage and the reduced expression of MMP-8. Conclusion:The condylar cartilage structure and metabolism of the female rats are 2 sensitive to dietary loading changes, estrogen level as well as aging. The proper balance of these factors seems to be essential for the maintenance of the condylar cartilage.

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Section: Introductionmentioning

confidence: 99%

MMP-3 and MMP-8 in rat mandibular condylar cartilage associated with dietary loading, estrogen level, and aging

Yu¹,

Mursu²,

Typpö³

et al. 2019

Archives of Oral Biology

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“…Twenty percent of the patients with disc disorders and DJD showed autoimmunity. This is interesting because it could be linked to infection, because these bacteria can directly damage the joints and they are known to trigger autoimmune disease in patients with genetic susceptibility [51,99,100]. In addition, the autoimmune damage of the TMJ could also be an early manifestation of a systemic condition [101].…”

Section: G2 Intragroup Discussionmentioning

confidence: 99%

Effectiveness of the Biopsychosocial Model Versus the Measurable Neurophysiological Model in Patients With Temporomandibular Joint Arthropathies

Catunda

Matos

Ferreira

et al. 2023

Preprint

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OBJECTIVE To evaluate the efficacy patients treated based on the biopsychosocial model, with a Michigan-type myorelaxant/stabilization splint combined with alternative therapies, and Neurophysiological model with intermediate Occlusal Devices in patients with temporomandibular joint (TMJ) arthropathies based on two different treatment philosophies. PATIENTS AND METHODS: This was an interventional and longitudinal study of the randomized clinical trial with blinding. The survey was approved by the CEP under: CAAE 66446216.6.0000.5207. Statistical analyzes were performed based on the selection of 43 patients with diagnosis of temporomandibular arthropathies after examination of the Diagnostic Criteria for Temporomandibular Dysfunction (DC / TMD) and assistance with images such as CT scans and magnetic resonance imaging. The patients were divided into two groups: G1-Biopsychosocial group and G2-Neurophysiological group. The variables studied were pain, mandibular function, need for alternative therapies and physiological parameters of muscle recruitment and masticatory cycle, measured by electromyography and kinesiography, respectively. All patients were followed for a minimum period of 06 to 09 months. RESULTS The results were favorable to both treatment groups in relation to the decrease in pain symptomatology, but were more consistent and remained smaller at the end of the evaluation in the neurophysiological group. Also significant was the difference in muscle recruitment during treatment with the G2 and less use of alternative therapies for pain control compared to the Biopsychosocial group. CONCLUSIONS Even in the case of a preliminary and unpublished study, this research provides strong indications of the benefit of the treatment with the Neurophysiological model in patients with TMJ arthritis, as well as the improvement of the symptomatic aspects, there was a clear improvement in muscle recruitment patterns, masticatory cycle, bone marrow regeneration and joint disc recapture. Further research with anti-etiologic treatment model should be performed to confirm these results. CLINICAL RELEVANCE: This innovative research highlights a new model for diagnosing and treating TMJ pathologies beyond traditional palliative treatment measures, enabling a more assertive anti-etiological treatment.

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“…Higher risk of a particular TMD diagnosis is related to Genotypes, both 1/1 and 2/2 in particular manifestations such as disc displacement without reduction (closed lock) (27) HLA It is the human major histocompatibility complex which was identified with specific alleles that have been associated with TMJ spondyloarthropathies and can also affect the peripheral and axial joints. (28) Higher risk for TMJ degenerative processes progress might be associated with the subjects of these alleles due to the presence of infectious agents with ensuing host interactions and the resulting inflammatory response being determined by their HLA phenotype (28,29) .…”

Section: Ankh Genementioning

confidence: 99%

Genetics and Oral Diseases: A Scoping Review

Fayed

Yassin

Hassan

et al. 2021

Egyptian Dental Journal

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Introduction:Recently genes act as hereditary blueprints of humans in our modern evidencebased dentistry era, Genomic wide association studies (GWAS) have investigated genetic and environmental factors which are considered instruments in genesis of complex and wide range of oral & maxillofacial disorders and syndromes. Their findings indicated that genetic mutation & polymorphisms are involved in periodontal diseases and temporomandibular disorders (TMDs) etiology & play a role by contributing to small effects and in determining the course and outcome of these disorders. Oral tissues are unique in different aspects, but they share many genetic etiopathogenesis of various disorders that are common to tissues throughout the body. Conditions affecting oral and maxillofacial tissues may occur as a part of systemic conditions or syndromes or single gene mutation or multifactorial gene disorders or X-linked diseases. Objectives:This article provides scopic reviews on the previous and current human genetics factors association with oral, periodontal, and temporomandibular disorders, which may lead to revolutionized treatment and prevention plans in the future.Methods: Databases search of literature were reviewed including Egyptian knowledge bank (EKB), and PubMed (NIH) by using scientific terms for periodontal disorders, oral diseases, TMDs and genetic mutation. Bibliographies of additional articles were reviewed to identify additional studies of relevance.

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HLA Analysis in Patients with Degenerative Diseases of the Temporomandibular Joint

Cited by 4 publications

References 9 publications

MMP-3 and MMP-8 in rat mandibular condylar cartilage associated with dietary loading, estrogen level, and aging

MMP-3 and MMP-8 in rat mandibular condylar cartilage associated with dietary loading, estrogen level, and aging

Effectiveness of the Biopsychosocial Model Versus the Measurable Neurophysiological Model in Patients With Temporomandibular Joint Arthropathies

Genetics and Oral Diseases: A Scoping Review

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