HLA-A, -B, -DR haplotype frequencies from DNA typing data of 26,266 Chinese bone marrow donors

Du, Ke‐Ming; Ji, Yongchang; Xie, J.‐H.; Fu, Min; Sun, Ying; Jin, Ye; Sun, Ji-Li; Yang, J. H.; Zhang, Zheng; Mao, Zhen; Liu, Dazhuang; Qian, Kun; Zhao, Tongmao

doi:10.1016/j.humimm.2007.04.006

Cited by 19 publications

(25 citation statements)

References 12 publications

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“…The studies by Cao et al, (10) Makhatadze et al, (11) Müller et al (12) and Bicalho et al (19) of populations from North America, Venezuela, Germany and Brazil, respectively corroborate this result. For Asians, the A*24-B*52-DRB1*15 haplotype was the most common (8.2%) different to the results reported by Du et al (9) of a Chinese population, who reported that the A*02-B*46-DRB1*09 haplotype was the most common.…”

Section: Discussioncontrasting

confidence: 84%

“…(8) The A*11 allele was frequently observed among Caucasians and Asians in our region and another study reported that it is widely distributed in a Chinese population. (9) …”

Section: Discussionmentioning

confidence: 99%

“…The results for this locus in this study confirm those of other studies involving different populations (Chinese, Venezuelan and German). (9,11,12) …”

Section: Discussionmentioning

confidence: 99%

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HLA-A, B and DRB1 allele and haplotype frequencies in volunteer bone marrow donors from the north of Parana State

Bardi

Jarduli

Jorge

et al. 2011

Rev. Bras. Hematol. Hemoter.

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BackgroundKnowledge of allele and haplotype frequencies of the human leukocyte antigen (HLA) system is important in the search for unrelated bone marrow donors. The Brazilian population is very heterogeneous and the HLA system is highly informative of populations because of the high level of polymorphisms.AimThe aim of this study was to characterize the immunogenetic profile of ethnic groups (Caucasians, Afro-Brazilians and Asians) in the north of Parana State.MethodsA study was carried out of 3978 voluntary bone marrow donors registered in the Brazilian National Bone Marrow Donor Registry and typed for the HLA-A, B and DRB1 (low resolution) loci. The alleles were characterized by the polymerase chain reaction sequence-specific oligonucleotides method using the LabType SSO kit (One Lambda, CA, USA). The ARLEQUIN v.3.11 computer program was used to calculate allele and haplotype frequenciesResultsThe most common alleles found in Caucasians were HLA-A*02, 24, 01; HLA-B*35, 44, 51; DRB1*11, 13, 07; for Afro-Brazilians they were HLA-A*02, 03, 30; HLA-B*35, 15, 44; DRB1*13, 11, 03; and for Asians they were: HLA-A*24, 02, 26; HLA-B*40, 51, 52; DRB1*04, 15, 09. The most common haplotype combinations were: HLA-A*01, B*08, DRB1*03 and HLA-A*29, B*44, DRB1*07 for Caucasians; HLA-A*29, B*44, DRB1*07 and HLA-A*01, B*08 and DRB1*03 for Afro-Brazilians; and HLA-A*24, B*52, DRB1*15 and HLA-A*24, B*40 and DRB1*09 for Asians.ConclusionThere is a need to target and expand bone marrow donor campaigns in the north of Parana State. The data of this study may be used as a reference by the Instituto Nacional de Cancer/Brazilian National Bone Marrow Donor Registry to evaluate the immunogenetic profile of populations in specific regions and in the selection of bone marrow donors

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Section: Discussioncontrasting

confidence: 84%

“…(8) The A*11 allele was frequently observed among Caucasians and Asians in our region and another study reported that it is widely distributed in a Chinese population. (9) …”

Section: Discussionmentioning

confidence: 99%

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HLA-A, B and DRB1 allele and haplotype frequencies in volunteer bone marrow donors from the north of Parana State

Bardi

Jarduli

Jorge

et al. 2011

Rev. Bras. Hematol. Hemoter.

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“…In particular, it has long been known that BD is associated with the major histocompatibility complex HLA–B5 allele (3) and, more specifically, with HLA–B51 (4), the predominant split of the HLA–B5 broad antigen (5–7). While the overrepresentation of HLA–B5 or HLA–B51 ( HLA–B51/B5 ) among individuals with BD has been abundantly replicated, substantial between-study differences were found in the strengths of this genetic association with reported risk increases that ranged between 1.3 and 16 (2,8).…”

Section: Introductionmentioning

confidence: 99%

HLA–B51/B5 and the risk of Behçet's disease: A systematic review and meta‐analysis of case–control genetic association studies

Menthon

LaValley

Maldini

et al. 2009

Arthritis & Rheumatism

404

231

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Objective To quantify by meta-analysis the genetic effect of the HLA–B5 or HLA–B51 (HLA–B51/B5) allele on the risk of developing Behçet’s disease (BD) and to look for potential effect modifiers. Methods Relevant studies were identified using the PubMed Medline database and manual searches of the literature. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated by using the random-effects model. Subgroup meta-analyses and meta-regression analyses were undertaken to investigate the effects of selected study-level parameters on the pooled OR. Heterogeneity was assessed using the I2 statistic. Pooled results were used to calculate population-attributable risks (PAR) for BD in relationship to HLA–B51/B5. Results A total of 4,800 patients with BD and 16,289 controls from 78 independent studies (published 1975–2007) were selected. The pooled OR of HLA–B51/B5 allele carriers to develop BD compared with noncarriers was 5.78 (95% CI 5.00–6.67), with moderate between-study heterogeneity (I2 = 61%). The subgroup analyses stratifying studies by geographic locations (Eastern Asia, Middle East/North Africa, Southern Europe, Northern/Eastern Europe) yielded consistent OR ranges (5.31–7.20), with I2 ranges of 52–70%. Univariate random-effects meta-regression indicated the percentage of male BD cases (P = 0.008) as a source of heterogeneity. The PAR within the various geographic areas were estimated at 32–52%. Conclusion The strength of the association between BD and HLA–B51/B5, and its consistency across populations of various ethnicities, lends further support to this allele being a primary and causal risk determinant for BD. Variations according to sex support an interaction of this allele with BD characteristics.

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“…The overall allelic groups of the studied population were consistent with the general South China population[45] and thus could be further evaluated. We found that there is a significant increase in the frequency of HLA-DRB1*14 among subjects with high antibody response levels compared with those with low antibody response levels.…”

Section: Discussionmentioning

confidence: 99%

Influence of HLA-DRB1 Alleles on the Variations of Antibody Response to Tuberculosis Serodiagnostic Antigens in Active Tuberculosis Patients

Zhou

et al. 2016

PLoS ONE

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Serology-based tests for tuberculosis (TB) diagnosis, though rapid, efficient and easily implemented, have so far shown unsatisfactory levels of sensitivity and specificity, probably due to variations of the antibody response in TB patients. The number and types of seropositive antigens vary from individual to individual. The person-to-person variations of antigen recognition may be linked to genetic polymorphisms of the human leukocyte antigen (HLA) class II alleles. In the present study, we find that there is a significant increase in the frequency of HLA-DRB1*14 (P = 2.5×10−4) among subjects with high antibody response levels compared to those with low antibody levels. HLA-DRB1*15, the most frequent allelic group in the studied active TB population, positively correlates with subjects with low antibody response levels rather than subjects with high antibody response levels (P = 0.005), which indicates the loss of relevant antigens for screening of patients with this allelic group. The potential association between HLA-DRB1 allelic group and individual antigens implies that TB diagnostic yield could be improved by the addition of antigens screened at the proteome scale in infected subjects from the HLA-DRB1*15 allelic group.

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HLA-A, -B, -DR haplotype frequencies from DNA typing data of 26,266 Chinese bone marrow donors

Cited by 19 publications

References 12 publications

HLA-A, B and DRB1 allele and haplotype frequencies in volunteer bone marrow donors from the north of Parana State

HLA-A, B and DRB1 allele and haplotype frequencies in volunteer bone marrow donors from the north of Parana State

HLA–B51/B5 and the risk of Behçet's disease: A systematic review and meta‐analysis of case–control genetic association studies

Influence of HLA-DRB1 Alleles on the Variations of Antibody Response to Tuberculosis Serodiagnostic Antigens in Active Tuberculosis Patients

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