HLA-A and B antigens in patients with peyronie disease

Deguchi, Takashi; Kuriyama, M; Maeda, Satoshi; Kawada, Yukimichi; Sakai, Shunsuke; Nishiura, Tsuneo

doi:10.1016/0090-4295(84)90068-2

Cited by 13 publications

(5 citation statements)

References 7 publications

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“…The ®rst two reports that demonstrated a positive association evaluated only 17 patients combined, 30,33 but two other studies, evaluating 80 patients, 10,13 failed to demonstrate a positive association. With respect to class II MHC, only Rompel 13 reported an association.…”

Section: Discussionmentioning

confidence: 99%

The genetics and immunology of Peyronie's disease

Noss

Day

et al. 2000

Int J Impot Res

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Peyronie's disease (PD) is a condition characterized by localized and often progressive ®brosis and scarring of the penis. This condition has an unknown etiology although several hypotheses have been proposed. These include traumatic, immunologic and genetic causes. We studied the genetics and immunology of PD using both molecular biologic and molecular genetic techniques.Men (n 283) with PD were identi®ed by retrospective chart review of one physician's of®ce practice. These men were contacted by telephone and asked to submit to an interview and blood test for genetic studies. Simultaneously, tissue and cells collected in the laboratory were examined by Western and Northern blot analysis for examination of protein and RNA for expression of HLA.Of the ®rst 107 men contacted, 24 were available and consented to interview and blood testing. The mean age was 60.3 y with an average duration of PD of 4.9 y. One patient had a family history of PD while no patients had Dupuytren's contracture. Twenty patients were considered to have primary disease while four were secondary. Eleven patients had tissue prepared for Northern blot analysis and nine patients were the subject of Western blot analysis. All tissue, both Peyronie's and control expressed class I MHC while no tissue expressed class II MHC. The expression of mRNA of class I MHC was equal for Peyronie's and control patients while the expression at the protein level was less in the PD patients.We conclude that PD may have multiple etiologic agents. One cannot exclude a class II MHC association but in our population, HLA DQ is not expressed. Class I MHC may be involved as the expression of class I MHC protein is different in Peyronie's patients than in controls. Genetic studies are ongoing.

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Section: Discussionmentioning

confidence: 99%

The genetics and immunology of Peyronie's disease

Noss

Day

et al. 2000

Int J Impot Res

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“…However, only small numbers of patients were investigated in those stud ies, and the question of HLA association in Peyronie's disease was discussed controversially [5][6][7][8]. In this study we report data on HLA class I as well as class II pheno types of the thus far largest number of patients presenting with this rather rare disease.…”

Section: Discussionmentioning

confidence: 93%

HLA Antigens in Peyronie’s Disease

et al. 1994

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This study presents data on HLA phenotypes of 52 unrelated patients suffering from idiopathic Peyronie’s disease. This first investigation on HLA class II antigens detected an association of HLA-DR3 and -DQw2 in this disorder. HLA typing was done from ACD-stabilized peripheral blood using the modified lymphocytotoxicity test. Antigen frequencies of the patient group were compared with those of healthy individuals of the local population. There were no deviations of frequencies for antigens of the B7 cross-reacting group as described in earlier studies. In addition none of the other class I antigens (HLA-A, -B, -C) showed any significant deviation in frequencies after correction of p values. Regarding class II antigens HLA-DR3 was detected in the patient group in 33.3% compared with 16.0% of the control population (corrected p < 0.05). The closely linked antigen DQw2 was found in 58.8 compared with 31.2% (corrected p < 0.005). Not only genetic factors can be stated by these findings. As HLA-DR3 and -DQw2 are known to be the typical associated antigens of organospecific autoimmune disorders, this suggests possible autoimmunological factors in this disorder of otherwise unknown etiology.

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“…Previous studies on HLA proposed an association of Peyronie's disease with the HLA-B7 cross-reacting group (4, 5). This association was not confirmed in subsequent studies on HLA-A and -B antigens in this disease (6,7). No data on HLA class I1 antigens, which are known to be of greater importance for disease susceptibility (8,9), have been published to date.…”

Section: Introductionmentioning

confidence: 78%

HLA association of idiopathic Peyronie's disease: An indication of autoimmune phenomena in etiopathogenesis?

1991

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HLA typing for class I and class II antigens was done in 52 unrelated patients suffering from idiopathic Peyronie's disease. The controversially discussed association with the HLA-B7 cross-reacting group could not be confirmed. Marked deviations of antigen frequencies were observed for HLA-A1, B8, Cw7, DR3 and DQw2 compared to healthy local controls. After correction of p-values, A1 (pc less than 0.05) and DQw2 (pc less than 0.01) remained significant. A possible association of Peyronie's disease with markers of the HLA-A1, B8, Cw7, DR3, DQw2 haplotype, as first described here, would suggest autoimmunological factors in this disorder of otherwise unknown etiopathogenesis.

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HLA-A and B antigens in patients with peyronie disease

Cited by 13 publications

References 7 publications

The genetics and immunology of Peyronie's disease

The genetics and immunology of Peyronie's disease

HLA Antigens in Peyronie’s Disease

HLA association of idiopathic Peyronie's disease: An indication of autoimmune phenomena in etiopathogenesis?

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