The genetics and immunology of Peyronie's disease

Noss, MB; Day, Nancy S.; Gj, Christ; Melman, Arnold

doi:10.1038/sj.ijir.3900591

Cited by 21 publications

(16 citation statements)

References 32 publications

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“…A widely accepted hypothesis on the etiology of the PD plaque is that it originates from trauma or microtrauma to the erect penis [44][45][46][47][48][49][50][51][52][53][54][55] in patients with genetic predisposition to form localized fibrosis as a response to trauma. [56][57][58][59][60][61][62]. The main pathological process is tissue fibrosis with disorganization of elastic fibers, combined in most cases with fibrin accumulation and different degrees of inflammation [48,50,[63][64][65][66][67][68][69][70][71][72][73][74][75].…”

Section: Etiology and Histopathologymentioning

confidence: 99%

The Management of Peyronie’s Disease: Evidence-based 2010 Guidelines

Ralph,

Gonzalez-Cadavid,

Mirone

et al. 2010

The Journal of Sexual Medicine

315

437

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Introduction The field of Peyronie’s disease is evolving and there is need for a state-of-the-art information in this area. Aim To develop an evidence-based state-of-the-art consensus report on the management of Peyronie’s disease. Methods To provide state-of-the-art knowledge regarding the prevalence, etiology, medical and surgical management of Peyronie’s Disease, representing the opinion of leading experts developed in a consensus process over a 2-year period. Main Outcome Measures Expert opinion was based on grading of evidence-based medical literature, widespread internal committee discussion, public presentation, and debate. Conclusions The real etiology of Peyronie’s disease and the mechanisms of formation of the plaque still remain obscure. Although conservative management is obtaining a progressively larger consensus among the experts, surgical correction still remains the mainstay treatment for this condition.

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Section: Etiology and Histopathologymentioning

confidence: 99%

The Management of Peyronie’s Disease: Evidence-based 2010 Guidelines

Ralph,

Gonzalez-Cadavid,

Mirone

et al. 2010

The Journal of Sexual Medicine

315

437

View full text Add to dashboard Cite

show abstract

“…However, other published reports, including a more recent prospective study of 154 consecutive PD patients, 48 have failed to show an association between PD and HLA subtypes. 49,50 …”

Section: Geneticsmentioning

confidence: 99%

Peyronie’s Disease: A Review of Etiology, Diagnosis, and Management

Bilgutay

Pastuszak

2015

Curr Sex Health Rep

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Peyronie’s Disease (PD) is a superficial fibrosing disorder of the penis resulting in plaque formation and penile deformity. Once considered rare, PD has more recently been found in up to 13% of men, and can negatively affect sexual and psychosocial function of both patients and their partners. While the etiology of PD is unclear, it is thought to result from an inciting traumatic event followed by aberrant fibrosis or dysregulated wound healing. The evaluation of men presenting with PD includes a detailed history and physical exam, focusing on the penis in both the flaccid and erect states. PD is often associated with erectile dysfunction (ED), as well as several other comorbidities. Laboratory testing is not needed to diagnose PD, although given the associations between PD and systemic diseases including hypogonadism, diabetes, and cardiovascular disease, screening and work-up for these conditions in men with PD may be warranted. Treatment modalities for PD are diverse and include oral, topical, intralesional, mechanical, and surgical therapies. Oral, topical, and mechanical therapies generally have little evidence supporting their efficacy. Several intralesional therapies, including interferon α2b and collagenase Clostridium hystiolyticum have demonstrated efficacy in the treatment of PD. Surgical treatment, indicated in men with significant, stable deformity, includes plication of the tunica albuginea, plaque incision/excision and grafting, and placement of inflatable penile prosthesis (IPP) with or without additional maneuvers to achieve desired results, and has high success rates.

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“…7–9 Concurrent fibrotic syndromes can be seen within the same individual, with 10–20% of men with PD also manifesting DD. 7 …”

Section: Introductionmentioning

confidence: 99%

The Genetic Basis of Peyronie Disease: A Review

Herati

Pastuszak

2016

Sexual Medicine Reviews

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Introduction Peyronie’s disease (PD) is progressive fibrotic disorder of the penile tunica albuginea that results in fibrotic penile plaques and may lead to penile deformity. Characterized by aberrant fibrosis resulting in part from persistence of myofibroblasts as well as altered gene expression, the molecular factors underpinning Peyronie’s disease and other related fibrotic diatheses are just being elucidated. A genetic link to PD was first identified using pedigree analyses three decades ago. However, the specific genetic factors that predispose patients to aberrant fibrosis remain unknown, and the relationships between these fibrotic conditions and other heritable diseases, including malignancy, are uncharacterized. Aim To review the current landscape linking molecular and genetic factors to aberrant fibrosis in PD as well as related fibrotic diatheses, including Dupuytren’s disease. Methods Review and evaluation of the literature from 1970 to present examining the genetic factors associated with PD. Main Outcome Measures Data describing the genetic factors associated with PD. Results We describe the known structural chromosomal abnormalities and single nucleotide polymorphisms associated with fibrotic diatheses, and discuss the spectrum of differential gene expression data comparing normal tissues and those derived from men with Peyronie’s or Dupuytren’s diseases. Finally, we discuss epigenetic mechanisms that may regulate gene expression and alter predisposition to fibrosis. Conclusion Although our current understanding of the genetic factors associated with PD are limited, significant advances have been made over the last three decades. Further research is necessary to provide a more comprehensive understanding of the landscape of genetic factors responsible for the development of PD.

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The genetics and immunology of Peyronie's disease

Cited by 21 publications

References 32 publications

The Management of Peyronie’s Disease: Evidence-based 2010 Guidelines

The Management of Peyronie’s Disease: Evidence-based 2010 Guidelines

Peyronie’s Disease: A Review of Etiology, Diagnosis, and Management

The Genetic Basis of Peyronie Disease: A Review

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