HL-A ANTIGENS IN ASYMPTOMATIC CHRONIC HBAg CARRIERS

Jeannet, M; Farquet, J J

doi:10.1016/s0140-6736(74)92251-x

Cited by 24 publications

(6 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HLA specificities have been evaluated in relation to hepatitis B virus (HBV) infections with conflicting results. Studies have shown no association (Majsky et al 1979), a negative association (Senger et al 1979), and different positive associations (Hillis et al 1977, Hillis et al 1978, Patterson et al 1977, Descamps et al 1977, Giani et al 1979, Jeannet & Farquet 1974 between HBV and HLA locus B specificities. The conflicting results may be attributable to evaluating different patterns of HBV infection or HBV infection in different This study was supported in part by the Medical Research Service of the Veterans Administration and USPHS (NIH) grant MOI RR00722-08, "General Clinical Research Center (OPDKRC)," to The Johns Hopkins University School of Medicine. hosts.…”

mentioning

confidence: 98%

HLA antigens and HBV infection: evaluation in the chronic carrier state and in a large family

et al. 1981

View full text Add to dashboard Cite

HLA antigens were determined in 65 apparently well chronic carriers of HBsAg, in race-matched controls and in 42 members of a family with a high frequency of hepatitis B virus infection. The only apparent significant association in the chronic carriers was negative, i.e., no HLA-B7 specificities were found among whites. B7 may confer resistance for whites to chronic infection with hepatitis B. In the family neither active (HBsAg) nor prior (anti-HBs) hepatitis B infection was associated with HLA specificities. HLA antigens in this family failed to provide a clue to the genetics of hepatitis B infection.

show abstract

mentioning

confidence: 98%

HLA antigens and HBV infection: evaluation in the chronic carrier state and in a large family

et al. 1981

View full text Add to dashboard Cite

show abstract

“…In recent years, many studies have been carried out to evaluate this genetic influence on immunologic diseases. Thus, an individual's immune responsiveness to Hepatitis B virus (HBV) has been shown to be under genetic MHC control and the course of the infection seems to be influenced by his/her HLA phenotype (3)(4)(5)(6)(7)(8)(9)(10).…”

mentioning

confidence: 99%

HLA‐associated non‐responsiveness to Hepatitis B vaccine

et al. 1990

View full text Add to dashboard Cite

HLA-A,B,DR antigens of two groups, one of normal individuals (N- = 31) and another of CRF (Chronic Renal Failure) patients (K- = 37), who did not develop anti-HBs protective antibodies after Hepatitis B (HB) vaccination, were compared, respectively, to the HLA antigens of two corresponding control groups (N+ = 52, K+ = 49), who responded to the vaccine. A statistically significant difference (Pc less than 0.02) in the frequency of HLA-DR3 was observed between responders and non-responders. An increased frequency of HLA-A1 and HLA-B8 in N- as well as of HLA-A1 and HLA-B35 in K- was also noticed, but this was not of statistical significance. As these antigens have been associated to both HBs antigenemia as well as chronic active hepatitis, we suggest that these genes or other genes in linkage to those may suppress the response to HBV vaccination while, in parallel, they may predispose to an autoimmune course of Hepatitis.

show abstract

“…An increase of AW19, A3 [17], BW41 [8] and a deficiency of B27, B17 [6], B15 and A2-B15 haplotype [3] have been reported in normal, healthy HBsAg carriers. B8 and A1-B8 haplotype have been implicated in chronic active hepatitis or CAH [9].…”

Section: Introductionmentioning

confidence: 99%

“…Although deviations in the frequency of several HLA antigens have now been reported in the HBsAg-positive subjects, no consistent patterns have emerged. An increase of AW19, A3 [17], BW41 [8] and a deficiency of B27, B17 [6], B15 and A2-Bl5 haplotype [3] have been reported in normal, healthy HBsAg carriers. B8 and Al-B8 haplotype have been implicated in chronic active hepatitis or CAH [9].…”

Section: Introductionmentioning

confidence: 99%