HLA antigens and HBV infection: evaluation in the chronic carrier state and in a large family

Sampliner, Richard E.; Bias, Wilma Β.; Carney, Elizabeth A.; Hillis, Argye; Hillis, W. Daniel

doi:10.1111/j.1399-0039.1981.tb01388.x

Cited by 14 publications

(6 citation statements)

References 14 publications

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“…The known decrease of the DR3 frequency from the north to the south of Italy has also prompted an analysis of this gene in accord with the geographical origin of our patients; the significant clustering of DR3 on delta-free patients has been confirmed when frequencies were analyzed by geographical subsets. In view of the failure to show clear-cut HLA differences between healthy HBsAg carriers and normal control populations in previous studies (12,13), one may conclude that the HLA imbalances demonstrated in the present study, are linked to the mechanism inducing CALD and do not identify an HLA set-up typical of the HBsAg carrier state. The DR3 gene is a recognized marker of autoimmunity (14) and has been associated with the autoimmune, nonviral variant of CALD (15).…”

Section: Discussioncontrasting

confidence: 78%

HLA-DR Antigens in HBsAg-Positive Chronic Active Liver Disease with and without Associated Delta Infection

et al. 1984

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The A, B, C and DR locus specificities of the human leukocyte antigens system (HLA) were determined in 45 delta-positive and 44 delta-negative Italian patients, all with HBsAg-positive chronic active liver disease; controls were 526 healthy Italian blood donors matched for age, sex and geographical origin. HLA-A, B, C gene frequencies were not significantly changed. In delta-positive patients, the frequencies of the DR locus specificities were: DR2, 37.8%; DR3, 20%; DR4, 11.1%. In the delta-negative patients, the frequencies were: DR2, 13.6%; DR3, 36.4%; DR4, 0%. Control frequencies were: DR2, 19.4%; DR3, 17.1%; DR4, 18.5%. The corrected p values of the differences between controls and delta-positive patients were: DR2, pc = 0.046; DR3, pc = NS (not significant); DR4, pc = NS. The corrected p values of the differences between controls and delta-negative patients were: DR2, pc = NS; DR3, pc = 0.03; DR4, pc = 0.002. These findings show that: (a) DR3, a genetic marker of autoimmunity, might assist the establishment of chronic HBsAg liver disease in the absence of delta superinfection; (b) DR2 is linked with failure to clear the delta agent, and (c) DR4 may protect from virus B persistence. Identification of adventitious factors such as delta may help uncover a subgroup of HBsAg carriers who are genetically predisposed to develop chronic liver disease.

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Section: Discussioncontrasting

confidence: 78%

HLA-DR Antigens in HBsAg-Positive Chronic Active Liver Disease with and without Associated Delta Infection

et al. 1984

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“…In general, studies of this kind have shown that the spreading and persistence of HBV are more efficient among Asian people than other ethnic groups (9,28,29). To explain this phenomenon, hypotheses have been raised concerning environmental, nutritional and genetic factors, but they are unproved (17,(30)(31)(32)(33)(34)(35)(36)(37).…”

Section: Discussionmentioning

confidence: 99%

A prospective study of hepatitis B virus markers in patients with chronic HBV infection from Brazilian families of Western and Asian origin

Carrilho

Ono‐Nita

Cardoso

et al. 2005

Braz J Med Biol Res

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The purpose of the present study was to determine the frequency of hepatitis B virus (HBV) markers in families of HBsAg-positive patients with chronic liver disease. Serum anti-HBc, HBsAg and antiHBs were determined by enzyme immunoassay and four subpopulations were considered: genetically related (consanguineous) and nongenetically related (non-consanguineous) Asian subjects and genetically related and non-genetically related Western subjects. A total of 165 and 186 relatives of Asian and Western origin were enrolled, respectively. The occurrence of HBsAg and anti-HBs antibodies was significantly higher (P < 0.0001) in family members of Asian origin (81.8%) than in family members of Western origin (36.5%). HBsAg was also more frequent among brothers (79.6 vs 8.5%; P < 0.0001), children (37.9 vs 3.3%; P < 0.0001) and other family members (33.9 vs 16.7%; P < 0.0007) of Asian than Western origin, respectivelly. No difference between groups was found for anti-HBs, which was more frequently observed in fathers, spouses and other non-genetic relatives. HBV infection was significantly higher in children of Asian than Western mothers (P < 0.0004). In both ethnic groups, the mothers contributed more to their children's infection than the fathers (P < 0.0001). Furthermore, HBsAg was more frequent among consanguineous members and anti-HBs among non-consanguineous members. These results suggest the occurrence of vertical transmission of HBV among consanguineous members and probably horizontal sexual transmission among non-consanguineous members of a family cluster. Thus, the high occurrence of dissemination of HBV infection characterizes family members as a high-risk group that calls for immunoprophylaxis. Finally, the study showed a high familial aggregation rate for both ethnic groups, 18/19 (94.7%) and 23/26 (88.5%) of the Asian and Western origin, respectively.

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“…and B8 and Bw3S (Scngar ct al. 1979), although other studies have found no association (Sampliner et al 1981, Majsky et al 1979). These Polynesians were monitored for circulating Hepatitis €3 surface antigen and antibodies to the surface and core antigens.…”

Section: Discussionmentioning

confidence: 76%

HLA in two islands of French Polynesia

et al. 1984

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The HLA‐A, B, and C antigens of 243 individuals from two Polynesian islands, Maiao and Hiva Oa, have been characterized. 328 haplotypes were defined by family analysis. Most frequent antigens were A2, A11, Aw24, A26, Aw34; Bw38, Bw39, Bw48, Bw55, Bw56, Bw60; Cw1, Cw3, and Cw4. Several other antigens were present at low frequency or were present on only one island. New variants of Bw22 and B40 were found. Despite an overall similarity in antigens of the two islands, the combination of HLA‐A, B and C antigens on the haplotype were distinctive. Of 328 total haplotypes identified, 65 were unique. Thirteen of these (20%) were present on both islands. Twenty‐eight (43%) were unique to Hiva Oa and 24 (37%) were unique to Maiao. Significant, positive linkage disequilibrium values (▵) for HLA‐A, B and HLA‐B, C antigens were also different for the two populations.

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HLA antigens and HBV infection: evaluation in the chronic carrier state and in a large family

Cited by 14 publications

References 14 publications

HLA-DR Antigens in HBsAg-Positive Chronic Active Liver Disease with and without Associated Delta Infection

HLA-DR Antigens in HBsAg-Positive Chronic Active Liver Disease with and without Associated Delta Infection

A prospective study of hepatitis B virus markers in patients with chronic HBV infection from Brazilian families of Western and Asian origin

HLA in two islands of French Polynesia

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