HIV status and hearing loss among children between 6 and 12 years of age at a large urban health facility in south western Uganda

Nakku, Doreen; Nyaiteera, Victoria; Llowet, Evelyn; Nanseera, Dennis; Nakalema, Gladys; Westerberg, Brian D.; Bajunirwe, Francis

doi:10.1016/j.ijporl.2017.08.011

Cited by 17 publications

(22 citation statements)

References 30 publications

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“…1 Human immunodeficiency virus (HIV) infection is associated with a higher risk of hearing impairment based on available preliminary data. 2 It is also known that about 75% of adults with AIDS has some form of hearing impairment attributable to the commonly present opportunistic infections and possible ototoxic medications. 3 Incidence of hearing loss among these patients ranges from 20-40%.…”

Section: Introductionmentioning

confidence: 99%

“…7 It is known that conductive Hearing loss (CHL) was commoner in children with HIV while sensorineural hearing loss (SNHL) was commoner in adults with HIV however even in adults HIV can also be associated with conductive hearing loss. 2 This is because the middle ear in these patients are often susceptible to invasion by organisms and inflammations resulting from a blockage of the Eustachian tube opening from the generalized lymphadenopathy common in these patients. 2,8 There is also a defective mechanism of chemotaxis and phagocytosis resulting in otitis media and conductive hearing loss.…”

Section: Introductionmentioning

confidence: 99%

“…2 This is because the middle ear in these patients are often susceptible to invasion by organisms and inflammations resulting from a blockage of the Eustachian tube opening from the generalized lymphadenopathy common in these patients. 2,8 There is also a defective mechanism of chemotaxis and phagocytosis resulting in otitis media and conductive hearing loss. 9 In HIV, there is poor humoral and cell mediated immunity which could lead to increase in opportunistic infections such as meningitis which could also affect hearing.…”

Section: Introductionmentioning

confidence: 99%

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Pure tone audiometric findings in HIV positive adults in university of Port Harcourt teaching hospital

Uju¹,

Alasia²

2021

Int J Res Med Sci

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Background: It is known that HIV infection is a risk factor for hearing loss. Therefore this study is to determine the pattern and severity of hearing loss and whether there is a correlation between the CD4 count and hearing impairment in the HIV positive adult patients seen in the infectious outpatient clinic of university of Port Harcourt teaching hospital (UPTH).Methods: A hospital based descriptive cross sectional study of consecutive patients that are HIV positive seen in the infectious outpatient clinic of UPTH within a period of three months, from May to July of 2020. The biodata, history of hearing difficulties and management of the disease was obtained using a semi structured questionnaire. All the patients had otoscopy done and hearing assessment with pure tone audiometry (PTA). The analysis was done with the SPSS version 25 software at a 95% confidence interval and a p value less than 0.05 was considered significant.Results: The study involved 234 subjects comprising 127 males and 107 females. Hearing impairment was seen in n=113 (48.29%). The patients with CD4 count less than 500 cells/mm2 was found to have more hearing loss; 55.8% than those with counts greater than 500 cells/mm2. Age distribution was statistically significant with a p=0.0001.Conclusions: The pure tone audiometric pattern in the majority of the studied population was more of CHL. The age, duration of ARVT and the CD4 count all had statistically significant association with hearing loss in the HIV positive adults.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pure tone audiometric findings in HIV positive adults in university of Port Harcourt teaching hospital

Uju¹,

Alasia²

2021

Int J Res Med Sci

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“…Automated audiometry is now deployed in a variety of environments. Tools like the SHOEBOX audiometer are used in clinicals and hospitals, but also in remote areas for humanitarian projects [37] and for research [38,39,40]. Many studies have resorted to automated audiometry to study the prevalence of hearing loss.…”

Section: Introductionmentioning

confidence: 99%

“…Many studies have resorted to automated audiometry to study the prevalence of hearing loss. For example, the SHOEBOX audiometer has been used to study the prevalence of hearing loss in children living in Northern Canada [38], HIV-positive children in Uganda [39], and in singing teachers and students [41] for example.…”

Section: Introductionmentioning

confidence: 99%

Machine Learning in Audiology: Applications and Implications

Charih¹

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Peripheral Auditory Function in Tanzanian Children Living With HIV With Clinically Normal Hearing

et al. 2023

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ImportanceDespite normal audiometry, adults living with HIV have lower distortion product otoacoustic emissions (DPOAEs) compared with HIV-negative controls, but the degree of these differences in children living with HIV is unknown. If subclinical auditory deficits are present, results could affect developmental outcomes in children living with HIV (CLWH).ObjectiveTo compare DPOAEs and auditory brainstem responses (ABR) between 2 age- and sex-matched groups of younger children with normal audiometry, 1 infected with HIV and the other uninfected.Design, Setting, and ParticipantsCohort study in an infectious disease center in Dar es Salaam, Tanzania. Participants included 340 Tanzanian children aged 3 to 9 years with clinically normal hearing, type A tympanograms bilaterally, and air-conduction thresholds of 20 dB HL or less from 0.5 to 8 kHz. Participants in the cohort repeated testing approximately every 6 months (approximately 2.2 sessions per participant) for a total of 744 total observations. Data were analyzed from March 2020 to January 2022.Main Outcomes and MeasuresDPOAE amplitudes from 1.5 to 8 kHz using an f2 to f1 ratio of 1.2 and L1/L2 values of 65/55 dB sound pressure level and click-evoked ABR using a slow (21.1/s) and fast (61.1/s) click rate.ResultsA total of 141 CLWH (70 female participants [49.3%]; mean [SD] age, 7.24 [1.67] years) and 199 HIV-negative individuals (99 female participants [49.7%]; mean [SD] age, 7.26 [1.44] years) participated in the study. The groups did not differ significantly in age, static immittance, or air-conduction thresholds. HIV status was independently associated with approximately 1.4 dB (95% CI, −3.28 to 0.30 dB) to 3.8 dB (95% CI, 6.03 to −1.99 dB) lower DPOAE amplitudes at 6 and 8 kHz bilaterally and 0.28 μV (95% CI, 0.01 to 0.33 μV) lower ABR wave V amplitudes in the right ear.Conclusions and RelevanceConsistent with previous findings in young adults, CLWH had slightly, but reliably, lower DPOAEs and ABR wave V amplitudes than HIV-negative controls. The magnitude of these differences was small, but results suggest an early and consistent association between HIV infection or treatment and outer hair cell and auditory brainstem responses in children as young as 3 years. These subclinical changes suggest tracking both auditory function and development outcomes in CLWH is warranted.

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HIV status and hearing loss among children between 6 and 12 years of age at a large urban health facility in south western Uganda

Cited by 17 publications

References 30 publications

Pure tone audiometric findings in HIV positive adults in university of Port Harcourt teaching hospital

Pure tone audiometric findings in HIV positive adults in university of Port Harcourt teaching hospital

Machine Learning in Audiology: Applications and Implications

Peripheral Auditory Function in Tanzanian Children Living With HIV With Clinically Normal Hearing

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