HIV Non-Occupational Post Exposure Prophylaxis in Nigeria: A Review of Research Evidence and Practice.

Abstract

Background: Although non-occupational Human Immunodeficiency Virus (HIV) post-exposure prophylaxis (nPEP) has been proven to be efficacious in preventing HIV, it remains an underutilized prevention strategy in Nigeria. We aimed to conduct an overview of research studies on nPEP and practice in Nigeria from 2002 to 2018 examining: sociodemographic characteristics of study sample, awareness, knowledge and prior use of nPEP, reasons for HIV nPEP, timeliness in presenting for PEP, antiretrovirals (ARVs) used for nPEP, side effects and adherence, monitoring and follow-up visits, adherence to guidelines and recommendations for nPEP by healthcare institutions and the strength of evidence of reviewed studies.
 Methods: An electronic search on PubMed, PubMed Central (PMC), cumulative Index to Nursing and Allied Health Literature (CINAHL), Scopus, Medline, Embase and Google Scholar for published studies on nPEP from January 2002 to December 2018. We conducted our search using different combinations of the keywords:

Implementation of HIV non-occupational post-exposure prophylaxis for men who have sex with men in 2 cities of Southwestern China

“…A systematic review in Nigeria also found 23.8% of the patients could not finish treatment induced by SEs. [49] Treatment completion was associated with SEs in our study. All these…”

“…A systematic review in Nigeria also found 23.8% of the patients could not finish treatment induced by SEs. [ 49 ] Treatment completion was associated with SEs in our study. All these suggest ongoing adherence education, medication guidance, and psychological supports are essential in the course of nPEP for avoiding non-compliance.…”

Hiv Non-Occupational Post-Exposure Prophylaxis in Ukraine

“…According to the findings of the current research and previously conducted studies in different countries, the most common consumers of nPEP are represented by the persons who had risky sexual contact (with partner of unknown or HIVpositive status), MSM group representatives, victims of sexual assault [12,13,21,22]. Nevertheless, nPEP may be considered underutilized strategy in HIV response actions [10,28,29].…”

An open-label evaluation of safety and tolerability of coformulated bictegravir/emtricitabine/tenofovir alafenamide for post-exposure prophylaxis following potential exposure to human immunodeficiency virus-1

“…This finding was similar to the results of the studies from the United States [ 17 ] and Europe [ 18 , 19 ] where nPEP was mostly sought by young men. In Africa, [ 20 , 21 ] however, participants were predominantly young women, and the most frequent reason for seeking nPEP was sexual assault.…”