HIV-infection and modern antiretroviral therapy impair sperm quality

Kehl, Sven; Weigel, M.; Müller, Daniel; Gentili, M; Hornemann, Amadeus; Sütterlin, Marc

doi:10.1007/s00404-011-1898-6

Cited by 49 publications

(35 citation statements)

References 39 publications

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“…This was evident from the decrease in the sperm count, sperm motility and an increase in abnormal forms with the use of TDF/FTC/EFV combination. This is in tandem with the findings of earlier studies (Azu et al, ; Kehl et al, ; Ogedengbe et al, ) who also reported semen abnormalities. The effect on sperm parameters could explain the lesser number of pregnancies and subsequently pubs in the rats on TDF/FTC/EFV combination.…”

Section: Discussionsupporting

confidence: 91%

Testicular microanatomical and hormonal alterations following use of antiretroviral therapy inSprague Dawleyrats: Role of Naringenin

et al. 2018

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Human immunodeficiency virus-infected man may require assisted reproductive technology not just for safer conception but also due to subfertility. The study investigated the effect of antiretroviral drugs on the fertility potentials of males and the possible protective role of Naringenin, using Sprague Dawley rats. Thirty adult male Sprague Dawley rats were grouped into-A: Distilled water; B: Highly Active Antiretroviral Therapy (HAART); C: Naringenin 40 mg/kg; D: Naringenin 80 mg/kg, E: HAART + Naringenin 40 mg/kg; F: HAART + Naringenin 80 mg/kg. The rats were euthanised after 10 weeks. Results showed a significant decrease in sperm count in group B when compared to the control and other groups. Spermatozoa with normal morphology also reduced significantly in the B group and progressive sperm motility reduced when compared to the control, D and the F group. The serum testosterone was not significantly different between groups A and B, however the groups C and D displayed significant increase when compared to groups A and B. The serum luteinising hormone was significantly higher in group B when compared to groups A, E and F. Our data suggest that Naringenin improves the male reproductive anatomy and function, therefore, it promises to be a beneficial adjuvant for mitigating HAART testicular and reproductive perturbations.

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Section: Discussionsupporting

confidence: 91%

Testicular microanatomical and hormonal alterations following use of antiretroviral therapy inSprague Dawleyrats: Role of Naringenin

et al. 2018

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“…Abnormalities are correlated with lower CD4+ cell counts and may include lower sperm volume, concentration, and motility along with higher rate of abnormal forms [98, 99]. Some data suggest that ARV therapy may have an adverse effect on semen quality: a longitudinal study of 34 men with serial semen analyses prior to ARV therapy and up to 48 weeks post-ARV initiation found that the proportion of progressively motile spermatozoa was low at all time points, but decreased significantly over the course of followup [100].…”

Section: Safer Conception With Serodiscordant Couplesmentioning

confidence: 99%

Preconception and Contraceptive Care for Women Living with HIV

Hoyt¹,

Storm²,

Aaron

et al. 2012

Infectious Diseases in Obstetrics and Gynecology

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Women living with HIV have fertility desires and intentions that are similar to those of uninfected women, and with advances in treatment most women can realistically plan to have and raise children to adulthood. Although HIV may have adverse effects on fertility, recent studies suggest that antiretroviral therapy may increase or restore fertility. Data indicate the increasing numbers of women living with HIV who are becoming pregnant, and that many pregnancies are unintended and contraception is underutilized, reflecting an unmet need for preconception care (PCC). In addition to the PCC appropriate for all women of reproductive age, women living with HIV require comprehensive, specialized care that addresses their unique needs. The goals of PCC for women living with HIV are to prevent unintended pregnancy, optimize maternal health prior to pregnancy, improve maternal and fetal outcomes in pregnancy, prevent perinatal HIV transmission, and prevent HIV transmission to an HIV-uninfected sexual partner when trying to conceive. This paper discusses the rationale for preconception counseling and care in the setting of HIV and reviews current literature relevant to the content and considerations in providing PCC for women living with HIV, with a primary focus on well-resourced settings.

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“…Chronic illnesses such as HIV/AIDS, diabetes mellitus and hypertension are associated with compromised erectile function and reduced fertility due to vascular damage, oxidative stress and atherosclerosis (Kehl et al., ; Selvin, Burnett, & Platz, ; Zona et al., ). Self‐medication with H. hemerocallidea for chronic illnesses and reproductive ailments is very common in South Africa (Appelbaum et al., ; Liwa et al., ; Mills, Cooper, Seely, & Kanfer, ).…”

Section: Introductionmentioning

confidence: 99%

Effects of treatment with Hypoxis hemerocallidea extract on sexual behaviour and reproductive parameters in male rats

2016

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Hypoxis hemerocallidea is used in traditional medicine in South Africa, for the treatment of male reproductive ailments and various chronic illnesses. Despite chronic use, its effects on male reproductive system are unknown. Male Wistar rats were treated orally daily for 28 (n = 18) and 56 days (n = 18). Treatment groups (n = 6/group) per treatment period were as follows: untreated control, 150 mg/kg and 300 mg/kg 70% ethanolic extract of H. hemerocallidea. Sexual behaviour observations were performed on days 17 and 42 of the study. Sperm, biochemical and testicular histopathological studies were carried out. Arousal and libido and serum testosterone increased after 56 days of treatment. There was an increase in epididymal sperm count at both treatment doses, with the 300 mg/kg dose showing a higher sperm count (p < .05) compared to the 150 mg/kg treatment group. The higher 300 mg/kg dose also showed an increase (p < .05) in sperm motility after 56 days of treatment. Histology showed an increase in germinal layer thickness, consistent with the observed increase in sperm count. Testicular oxidative status improved after 56 days of treatment. Results suggest that chronic treatment with H. hemerocallidea may improve male sexual function and fertility parameters and may protect testes from oxidative damage.

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HIV-infection and modern antiretroviral therapy impair sperm quality

Abstract: The spermiogram in HIV-1-infected men in comparison to a control group of healthy men is negatively altered. Especially in men with HAART, ejaculate volume as well as sperm morphology and motility changed significantly.

Cited by 49 publications

References 39 publications

Testicular microanatomical and hormonal alterations following use of antiretroviral therapy inSprague Dawleyrats: Role of Naringenin

Testicular microanatomical and hormonal alterations following use of antiretroviral therapy inSprague Dawleyrats: Role of Naringenin

Preconception and Contraceptive Care for Women Living with HIV

Effects of treatment with Hypoxis hemerocallidea extract on sexual behaviour and reproductive parameters in male rats

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