HIV infection and COVID-19: risk factors for severe disease

Etienne, Nicolas; Karmochkine, Marina; Slama, Laurence; Pavie, Juliette; Batisse, Dominique; Usubillaga, Rafael; Letembet, V.; Brazille, Patricia; Canouï, Etienne; Slama, Dorsaf; Joumaa, Hassan; Canouï‐Poitrine, Florence; Segaux, Lauriane; Weiss, Laurence; Viard, Jean Paul; Salmon, Dominique

doi:10.1097/qad.0000000000002651

Cited by 73 publications

(81 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, providing a proper ART to PLWH during the COVID-19 pandemic is crucial for medical systems around the world ( Nakamoto et al, 2020 , Patel et al, 2020 , Sharov, 2020a , Sharov, 2020b ). The healthcare systems must be sustained by governmental actions aimed at prevention of pharmaceutical supply chain disruptions, as in the situation of truly global society such disruptions may bring on tremendous harm to the world population ( Donskikh, 2019 , Etienne et al, 2020 , Guo et al, 2020 , Lysenko, 2019 , Moskovkin, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

HIV/SARS-CoV-2 co-infection: T cell profile, cytokine dynamics and role of exhausted lymphocytes

Sharov

2021

International Journal of Infectious Diseases

View full text Add to dashboard Cite

Highlights HIV-1 and SARS-CoV-2 are likely to exhibit a synergic effect on immunity in serious cases of HIV/SARS-CoV-2 co-infection. Exhausted T lymphocyte dynamics along with IL-10 and TGFβ growth during COVID-19 course may be an effective prognostic marker of this synergy as well as overall prognosis of the co-infection disease. HIV without antiretroviral therapy may be a dangerous comorbidity of COVID-19. Conversely, COVID-19 clinical course and immune status of HIV patients with a proper ART did not differ significantly from the control group of SARS-CoV-2 positive people without HIV. SARS-CoV-2 was detected to exasperate a loss of lymphocytic cytokine-producing ability with respect to IL-2, TNFα and IFNγ.

show abstract

Section: Discussionmentioning

confidence: 99%

HIV/SARS-CoV-2 co-infection: T cell profile, cytokine dynamics and role of exhausted lymphocytes

Sharov

2021

International Journal of Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…We identified 1,908 records and included 19 studies in our final qualitative analysis ( Figure 1). Seventeen studies [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] were peer-reviewed and two were preprints [27,28]. Quality appraisal is included in Tables 1, S2 and S3.…”

Section: Summary Of Included Studiesmentioning

confidence: 99%

“…CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) preprint and/or PLWH without COVID-19, [11,12,14,15,23,25,26], two studies compared only to a HIV-negative cohort [13,19], two studies compared only cohorts of PLWH with and without COVID-19 [17,22] and three studies compared only the characteristics of PLWH with different COVID-19 disease severity [20,21,24].…”

Section: Summary Of Included Studiesmentioning

confidence: 99%

“…A US hospital study found that PLWH and COVID-19 who survived were more likely to have been treated with NRTIs that those PLWH who died (99% vs 89%, p=0.04) in univariate analysis [13]. Seven smaller studies (n=18-93 PLWH with COVID- 19) reported no significant association between ART-regimen and COVID-19 severity amongst PLWH [14,15,17,[20][21][22][23][24].…”

Section: Impact Of Art Regimen On Covid-19 Outcomesmentioning

confidence: 99%

See 1 more Smart Citation

Risk of adverse COVID-19 outcomes for people living with HIV: a rapid review and meta-analysis

Mellor

Bast

Jones

et al. 2020

Preprint

View full text Add to dashboard Cite

Objective: To assess whether people living with HIV (PLWH) are at increased risk of COVID-19 mortality or adverse outcomes, and whether antiretroviral therapy (ART) influences this risk. Design: Rapid review with meta-analysis and narrative synthesis. Methods: We searched databases including Embase, Medline, medRxiv, and Google Scholar up to 26th August 2020 for studies describing COVID-19 outcomes in PLWH and conducted a meta-analysis of higher quality studies. Results: We identified 1,908 studies and included 19 in the review. In a meta-analysis of five studies, PLWH had a higher risk of COVID-19 mortality (hazard ratio (HR) 1.93, 95% Confidence Interval (CI): 1.59-2.34) compared to people without HIV. Risk of death remained elevated for PLWH in a subgroup analysis of hospitalised cohorts (HR 1.54, 95% CI: 1.05-2.24) and studies of PLWH across all settings (HR 2.08, 95%CI: 1.69-2.56). Eight other studies assessed the association between HIV and COVID-19 outcomes, but provided inconclusive, lower-quality evidence due to potential confounding and selection bias. There were insufficient data on the effect of CD4+ T cell count and HIV viral load on COVID-19 outcomes. Eleven studies reported COVID-19 outcomes by ART-regimen. In the two largest studies, tenofovir-disoproxil-fumarate (TDF)-based regimens were associated with a lower risk of adverse COVID-19 outcomes, although these analyses are susceptible to confounding by comorbidities. Conclusion: Evidence is emerging that suggests a moderately increased risk of COVID-19 mortality amongst PLWH. Further investigation into the relationship between COVID-19 outcomes and CD4+ T cell count, HIV viral load, ART and the use of TDF is warranted.

show abstract

“…HIV merupakan salah satu penyakit kronis yang berkaitan dengan sistem imun. Studi literatur yang telah dilakukan menemukan bahwa Orang dengan HIV (ODH) rentan untuk terkena penyakit COVID-19 (Chenneville et al, 2020), walaupun ada penelitian juga yang menyatakan sebaliknya (Etienne et al, 2020;Laurence, 2020). Bagaimanapun juga, kemungkinan bahwa orang dengan HIV yang tidak mengonsumsi obat antiretrovirus (ARV) secara rutin, lebih rentan untuk terkena infeksi oportunistik termasuk COVID-19, tidak dapat diabaikan.…”

Section: |unclassified

Program Pencegahan Penularan COVID-19 pada Komunitas Ibu Rumah Tangga dengan HIV di Surabaya

Silitonga

Rambung

Nainggolan

et al. 2020

ABDIMAS J. Pengabdi. Masy. Univ. Merdeka Malang

View full text Add to dashboard Cite

HIV infection and COVID-19: risk factors for severe disease

Abstract: Supplemental Digital Content is available in the text

Cited by 73 publications

References 16 publications

HIV/SARS-CoV-2 co-infection: T cell profile, cytokine dynamics and role of exhausted lymphocytes

HIV/SARS-CoV-2 co-infection: T cell profile, cytokine dynamics and role of exhausted lymphocytes

Risk of adverse COVID-19 outcomes for people living with HIV: a rapid review and meta-analysis

Program Pencegahan Penularan COVID-19 pada Komunitas Ibu Rumah Tangga dengan HIV di Surabaya

Contact Info

Product

Resources

About