HIV, Cognition and Women

Maki, Pauline M.; Martin-Thormeyer, Eileen M.

doi:10.1007/s11065-009-9093-2

Cited by 83 publications

(70 citation statements)

References 95 publications

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“…Those studies that have focused on women, suggest that HIV seropositive women evidence more impairment than HIV negative women, with the greatest impairments observed on psychomotor tasks, and that impairment was more frequently observed in those not receiving HAART. 61,62 In general, older age is associated with poorer performance in multiple domains including memory, executive functioning and motor/psychomotor performance when older adults are compared to younger adults. 60,63 Age increases risk for neurocognitive symptoms in women with HIV.…”

Section: Neuropsychiatric Factors and Hiv In Older Adultsmentioning

confidence: 99%

HIV/AIDS in Older Women: Unique Challenges, Unmet Needs

Durvasula

2014

Behavioral Medicine

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As persons living with HIV/AIDS live longer, both the prevalence and incidence of HIV infection in older women is expected to increase, and this review presents a model and review of the extant literature on older women with HIV/AIDS in the United States. Older women are rarely addressed in the discourse about HIV risk and prevention, and their concerns are often missed by risk reduction programs that typically target men and younger adults. Societal biases around aging can compound factors such as stigma and disclosure for older women. Primary care providers are often not recommending routine HIV testing to older women, or addressing the impact of age related physiological changes on risk and sexual health. Many older women may be starting new relationships and the role of relational variables that are specific to this group of women are key in understanding prevention and treatment. Empirical research focused on the needs of older women, and recognition of the diverse composition and needs of this group is needed to inform prevention, intervention and best practices with this population of women.

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Section: Neuropsychiatric Factors and Hiv In Older Adultsmentioning

confidence: 99%

HIV/AIDS in Older Women: Unique Challenges, Unmet Needs

Durvasula

2014

Behavioral Medicine

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“…Overall, the results of our study only partially confirm our hypothesis. Although preliminary, this study offers an important contribution to the field, especially because women are still under-represented in neuropsychological studies of HIV (Maki & Martin-Thormeyer, 2009) Firstly, our findings indicate that HIV-infected women experience high levels of depressive symptoms. These findings are consistent with prior work that revealed a significant prevalence of depression among HIV-infected patients (Leserman, 2003, Ciesla & Roberts, 2001, and particularly among women (Bragança & Palha, 2011;Pereira & Canavarro, 2011;Ickovics et al, 2001;Rabkin, 2008;Valverde et al, 2007).…”

Section: Discussionmentioning

confidence: 78%

“…However, given that most of these studies were conducted in predominantly male samples, this finding is particularly important because depression occurs frequently in HIV-infected women. Indeed, given the higher prevalence of depression among women (Wisniewski et al, 2005), it is possible, as pointed out by Maki and Martin-Thormeyer (2009), that the effects of depression on neurocognitive functions are more pervasive among women. In addition, women with mild/moderate and severe depressive symptoms were, respectively, five and three times more likely to present neurocognitive impairment than non depressed women.…”

Section: Discussionmentioning

confidence: 99%

“…Also, neuropsychological studies have confirmed that cognitive impairment occurs in a substantial (15-50%) proportion of patients (Schouten et al, 2011). Worldwide, the knowledge of neurocognitive complications of HIV infection is fundamentally based on studies involving men, and women are still under-represented in neuropsychological studies of HIV (Maki & Martin-Thormeyer, 2009). …”

Section: Introductionmentioning

confidence: 99%

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Depressive Symptoms and Neurocognitive Performance Among HIV-Infected Women

et al. 2013

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The aims of this paper were to explore the relationship between depressive symptoms and neuropsychological performance in a sample of HIV-infected women, and to examine the contribution of demographic, HIV-related variables, and depressive symptoms to neurocognitive performance. In reported by 31.1% of the women. Findings indicated that severe levels of depressive symptoms were significantly associated with reduced cognitive functioning in HIV-infected women, particularly in domains of attention, psychomotor speed, and construction. Older age and low education level were significantly associated with neurocognitive impairment in univariate analyses. In the multivariate model, only depressive symptoms were a significant independent risk factor for neurocognitive impairment. Compared to participants with none/minimal depressive symptoms, those with moderate and severe depressive symptoms had an odds ratio (OR) of 5.03 (95% CI, 1.33-18.99) and 3.22 (95% CI, 1.15-9.06), respectively. These findings support continued investigation of the presence of neurocognitive impairment, particularly among women, and may help mental health providers with early detection, planning, and implementation of more effective interventions.

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“…30 However, as most of the women in these studies are premenopausal, little is known about cognitive decline among postmenopausal women with HIV. 31 Among older individuals with HIV, 68% have reported some degree of cognitive impairment. Causes are doubtless multifactorial and include HIV-specific risk factors including low nadir CD4+ lymphocyte count and perhaps the use of antiretroviral regimens with poor central nervous system penetration, as well as those found in the general population, including older age, chronic HCV co-infection, polypharmacy, and frailty, and, perhaps, the use of antiretroviral regimens with poor central nervous system penetration.…”

Section: Cognitive Impairmentmentioning

confidence: 99%

Primary Care of Women Aging with HIV (2014/116)

2015

J Midwife Womens Health

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Women are living longer with HIV infection, but their life expectancy is shorter than for women in the general population. How best to manage the multiple comorbidities and polypharmacy that are common in HIV infected individuals has not been studied. This paper explores areas where the primary care of women with HIV may differ from that of aging women in the general population. We also discuss aspects of care that may not commonly be considered in those under the age of 65, specifically multimorbidity and polypharmacy.Incorporating a gerontologic approach in the care of these women may optimize outcomes until research provides more definitive answers as to how best to collaborate with women with HIV to provide them with optimal care.

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HIV, Cognition and Women

Cited by 83 publications

References 95 publications

HIV/AIDS in Older Women: Unique Challenges, Unmet Needs

HIV/AIDS in Older Women: Unique Challenges, Unmet Needs

Depressive Symptoms and Neurocognitive Performance Among HIV-Infected Women

Primary Care of Women Aging with HIV (2014/116)

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